Part one: Introduction. 1. Drug development and positron emission tomography; B. Campbell. 2. Positron emission tomography: Basic principles and potential interest for pharmacological studies; B. Mazoyer. 3. Is PET a tool for drug evaluation? B. Långström, et al. Part two: Psychiatry. 4. PET in neuropsychiatric drug development; L. Farde. 5. Radioligand disposition and metabolism - Key information in early drug development; C. Halldin, et al. 6. PET studies in the early clinical development of a new antipsychotic; J.M. Sitsen, L. Farde. 7. PET in the development of Dopamine D1 antagonists as new potential antipsychotic drugs; C. Foged, et al. 8. Is the 5-HT2-receptor a target for antipsychotic drug action? PET studies on dopamine (D2) and serotonin (5-HT2) receptor occupancy in patients and healthy subjects; S. Nyberg, et al. 9. Preclinical development of a radioligand for the study of central 5-HT1a receptors with PET-[11C]WAY-100635; V.W. Pike, et al. 10. Comparative in vivo and vitro selectivity of zolpidem for omega (Benzodiazepine) modulatory site subtypes; J. Benavides, et al. 11. Do the effects of muscarinic receptor blockade on brain glucose consumption mimic the cortical and subcortical metabolic pattern of Alzheimer's disease in normal volunteers? J. Blin, et al. Part three: Neurology. 12. PET evaluation of drug treatment in ischemic stroke and Alzheimer's disease; W.- D. Heiss. 13. PET imaging of cerebral perfusion and oxygen metabolism in acute ischemic stroke: Implications for management and therapy;J.C. Baron. 14. Pharmacokinetics: Kinetic modelling of MAO inhibitors and D2 antagonists; A. Lammertsma, C.J. Bench. 15. Brain activation under drug treatment; P. Grasby, K.J. Friston. 16. Modifying the progression of Parkinson's disease; P. Morrish, et al. 17. COMT inhibition: Pharmacology of tolcapone and 6- (18F)-Fluoro-L-Dopa (FDOPA) PET results; K. Jorga. 18. Interaction of Lisuride with dopaminergic receptors; B. Mazière, A. Antonini. 19. Lisuride and [C-11]-raclopride interaction at the D2 receptor site; K.L. Leenders. Part four: Cardiology. 20. Drug design in cardiology: the pharmaceutical industry point of view; R. Gradnik. 21. Myocardial receptors and their interaction with cardiovascular drugs; A. Syrota, P. Merlet. 22. The pathophysiological background of cardiovascular diseases and its impact on diagnosis and treatment; P.G. Camici. 23. Effect of cardiotonic drugs on myocardial oxygen consumption and efficiency as assessed by 11C-acetate and PET; L.M. Voipio-Pulkki, et al. 24. Integration of new and classical techniques in drug development. PET application to Propionyl-L-carnitine pharmacokinetic study; A. Longo, et al. Part five: Oncology. 25. The view of the EORTC new drug development office on PET in (pre)clinical trials of anticancer drugs; H.R. Hendriks, J. Wanders. 26. Bottlenecks in anticancer drug discovery and development: In vivo pharmacokinetic and pharmacodynamic issues and the potential role of PET; P. Workman. 27. Radiolabelled anticancer drugs for in vivo pharmacokinetic studies by
