Preface; E.A. Jones, A.J. Meijer, R.A.F.M. Chamuleau. Acknowledgements. Part 1: Nitrogen metabolism in relation to liver disease. 1. Novel aspects of nitrogen metabolism in liver disease; D. Häussinger, et al. 2. The interorgan exchange of amino acids and ammonia and the effect of plasmapheresis in acute liver failure; J.O. Clemmesen, et al. 3. Metabolic consequences of an upper gastro-intestinal bleed in patients with cirrhosis; S.W.M. Olde Damink, et al. 4. Citrin deficiency; T. Saheki, et al. Part 2: Assessment of overt and minimal hepatic encephalopathy. 5. Assessment of hepatic encephalopathy; K. Weissenborn. 6. Evaluation of mental state in a clinical trial of MARS for patients with acute hepatic encephalopathy: comparison of two scales; J. Vaquero, et al. 7. Relationship between minimal hepatic encephalopathy and extrapyramidal signs in cirrhotic patients; R. Jover, et al. 8. Evaluation of visual focus in cirrhotic patients; S. Schiff, et al. 9. Detection of minimal hepatic encephalopathy: EEG spectral analysis vs. cognitive evoked potentials; P. Valenti, et al. 10. Analysis of critical flicker frequency threshold in hepatic encephalopathy: dynamics and cortical activations; G. Kircheis, et al. 11. Cortical origin of mini-asterixis in hepatic encephalopathy; L. Timmermann, et al. 12. Imaging studies in hepatic encephalopathy; B. Ahl, et al. 13. Subclinical and overt hepatic encephalopathy - etection and treatment control by proton magnetic resonance spectroscopy (1H-MRS); H.G. Hass, et al. Part 3: Animal models of acute liver failure.14. Long-term observations on rats with thioacetamide-induced hepatic failure; W. Hilgier, et al. 15. Reversal of Fischer's ratio in an anaesthetised porcine model of acute liver failure; K.J. Dabos, et al. Part 4: Neuropsychiatric dysfunction in chronic liver disease. 16. Experience with neuropsychiatric complications of interferon-based therapy for chronic viral hepatitis; K.D. Mullen. 17. Cognitive effects of long-term interferon treatment for chronic viral hepatitis; E. De Toni, et al. 18. Is fatigue of cholestasis mediated by altered central serotoninergic neurotransmission? T. Çelik, et al. 19. Reduced pallidal magnetisation transfer ratios are associated with fatigue in pre-cirrhotic patients with primary biliary cirrhosis; D.M. Forton, et al. Part 5: Pathophysiology of hepatic encephalopathy. 20. Pathogenesis of hepatic encephalopathy; K.D. Mullen. 21. Effect of blood plasma components from patients with hepatic encephalopathy on electrophysiological activity of primary frontal cortex networks in vitro; J. Loock, et al. 22. Hyperammonemia and liver failure alter signal transduction associated with glutamate receptors and modulation of guanylate cyclase by nitric oxide; R. Corbalán, et al. 23. Increased cerebral and peripheral vasodilation, and whole body nitric oxide production after insertion of a transjugular intrahepatic portal-systemic stent in patients with cirrhosis; R. Jalan, et al. 24. Concomitant changes in melatonin metabolism and in hypothalamic histamine in rats with a portacaval anastomosis; V. Lozeva-Thomas, et al. 25. Brain energy metabolism in acute liver failure: studies using NMR spectroscopy;