Chapter 1: Disfunction of the Apoptotic Pathway in Cancer Cells by Lily Yang Chapter 2: Calcium Signaling and Apoptosis Resistance of Cancer Cells by Natalia Prevarskaya, Roman Skryma and Yaroslav Shuba Chapter 3: Cell Clearance and Cancer by Bengt Fadeel Chapter 4: Specific, Pro-Poptotic Cell-Signaling: Design of Novel, Recombinant Targeted Antitumor Agents Operating Exclusively Through Modulation of Cellular Apoptotic Events: Novel, Targeted Pro-Apoptotic Therapeutic Agents by Yuying Liu, Lawrence H. Cheung and Michael G. Rosenblum Chapter 5: Targeting Oncogenes which Regulate Apoptosis by Andrew C. Phillips Chapter 6: Targeting Cyclins to Cause Cancer Cell Apoptosis by Suparna Mazumder, Dragos Plesca and Alexandru Almasan Chapter 7: Apoptosis Induction by Tumor-Targeted Toxins by Andrew Thorburn Chapter 8: Targeting Cell-Death Pathways in Multiple Myeloma: Therapeutic Implications by Dharminder Chauhan and Kenneth Anderson Chapter 9: Cephalostatin 1-Induced Apoptosis in Tumor Cells Selective Induction of Smac/DIABLO Release by Verena M. Dirsch and Angelika M. Vollmar Chapter10: Hamlet; a Novel Tool to Identify Apoptotic Pathways in Tumor Cells 223 by Caroline Düringer, Oskar Hallgren, Lotta Gustafsson, Jenny Petterson, Ann-Kristin Mossberg, Taras Manilov and Catharina Svanborg Chapter 11: Cancer Immunotherapy: On the Trail of a Cure? by Thomas S. Griffith, Troy J. Kemp1, Aaron T. Ludwig, Jill M. Moore, and Rebecca L. VanOosten Chapter 12: Histone Deacetylase Inhibitors as a Treatment of Trail-Resistant Cancers by Jiri Neuzil, Ladislav Andera and Brian Gabrielli Chapter 13: Basis of Cell Kill Following Clinical Radiotherapy by Oliver Faulhaber and Robert G Bristow Chapter 14: Imaging of Apoptotic Cells in Vivo by Juhana Hakumäki Chapter15: Apoptosis-Inducing Anticancer Drugs in Clinical Trials by Wei Hu and John J. Kavanagh