Store-operated Ca2+ entry (SOCE) pathways

<p>Preface (C. Romanin, W. F. Graier, K. Groschner).- SECTION 1: SOCE – Fundamental mechanistic concepts.- Introduction (J. W. Putney).- 1.1 The STIM-Orai pathway.- Structural insights into Ca²⁺ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura).- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan).- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin).- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca²⁺ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem).- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca²⁺ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu).- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca).- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca²⁺ entry: Endogenous messengers and mediators (V. M. Bolotina).- SECTION 2: SOCE – Crosstalk between organelle and cellular compartments.- Introduction: Ca²⁺ signaling and gene regulation: An introduction (A. B. Parekh).- 2.1 New aspects of the contribut</p>ion of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. Tepikin).- 2.2 New aspects of the contribution of ER to SOCE regulation. The contribution of SERCA to the regulation of SOCE (J. García-Sancho, M. T. Alonso).- 2.3 New aspects of the contribution of ER to SOCE regulation. TRPC proteins as a link between plasma membrane ion transport and intracellular Ca²⁺ stores (A. Bavencoffe, M. X. Zhu).- 2.4 The role of mitochondria in the activation/maintenance of SOCE. Store-operated Ca²⁺ entry and mitochondria (A. Spät, G. Szanda).- 2.5 The role of mitochondria in the activation/maintenance of SOCE. Local regulation of plasma membrane channels by mitochondria (N. Demaurex, M. Frieden).- 2.6 The role of mitochondria in the activation/maintenance of SOCE. The contribution of distinct mitochondrial Ca²⁺ uptake mechanisms, mitochondrial motility and location to store-operated Ca²⁺ entry (R. Malli, W. F. Graier).- 2.7 Tissue specificity. The role of nanospaces between the organellar membranes in smooth muscle Ca²⁺ signaling (N. Fameli, A. M. Evans, C. van Breemen).- 2.8 Tissue specificity. SOCE – implications for Ca²⁺ handling in endothelial cells (L. A. Blatter).- SECTION 3: SOCE – Molecular and cellular (patho)physiology.- Introduction (J. A. Rosado).- 3.1 Immune system. SOCE mediated by STIM and Orai genes in immune function and disease (S. Feske).- 3.2: Cardiovascular system. STIM1/Orai1-mediated store-operated Ca²⁺ entry in cardiovascular disease (R. K. Motiani, M. Trebak).- 3.3: Cardiovascular system. TRPC/Orai-containing channels, Na⁺/Ca²⁺ + exchanger and Ca²⁺ handling in hypertension (V. A. Golovina).- 3.4: Cardiovascular system. SOCE and TRPC/STIM/Orai signaling in cardiac myocytes (H. Watanabe, T. Ohba, H. Ito).- 3.5: Cardiovascular system. SOCE as a determinant of cardiac pacemaker activity (D.G. Allen, Y. K. Ju, J. Liu, M. S. Imtiaz).- 3.6: Cardiovascular system. SOCE and Ca²⁺ handling in platelet dysfunction (J. J. Lopez, G. M. Salido, J. A. Rosado).- 3.7: Cardiovascular system. Store-operated Ca²⁺ entry in endothelial pathophysiology (K. Groschner, M. Poteser).- 3.8: Nervous system. Pathophysiological perspective of neuronal store-operated Ca²⁺ signaling (S. Bollimuntha, B. Pani, B. B. Singh).- 3.9: Skeletal muscle. Store-operated Ca²⁺ entry and STIM/Orai signaling in skeletal muscle (J. A. Stiber, P. B. Rosenberg).- 3.10: Skeletal muscle. Store-operated channels and Ca²+ handling in muscular dystrophy (U. T. Ruegg, G. Shapovalov, K. Jacobson, J. Reutenauer-Patte, H. Ismail, O. M. Dorchies, P. Avdonin).- 3.11: Reproductive system. Store-operated Ca²⁺ entry in germ cells – role in egg activation (Z. Machaty, C. Wang, K. Lee).<p></p><p></p>