Otto Braun-Falco,
Hans C. Korting,
Howard I. Maibach
Springer Berlin Heidelberg
0e druk, 1992
9783540556466
Liposome Dermatics
Griesbach Conference
Specificaties
Paperback, 364 blz.
|
Engels
Springer Berlin Heidelberg |
0e druk, 1992
ISBN13: 9783540556466
Rubricering
Onderdeel van serie
Griesbach Konferenz Griesbach Conference
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
In a multi-disciplinary approach the book deals with
liposome dermatics fromthe chemist's, pharmacist's,
biologist's as well as clinician's point of view. It
features the production of liposomes, appropriate raw
materials, encapsulation of active ingredients, possible
incorporation into vehicles such as gels, assessment of
stability, fate of liposomes and active ingredients exposed
to animaland human skin both in vitro and in vivo, activity
of topical liposome preparations in normal and inflamed skin
in animal and man as well as efficacy in skin diseases in
man. Other aspects covered comprise the ecological and
juridic area. The scope being theoretical and practical at a
time, the book provides a sound basis for future
developments to meet the needs of patients suffering from so
far recalcitrant skin diseases.
Specificaties
ISBN13:9783540556466
Taal:Engels
Bindwijze:paperback
Aantal pagina's:364
Uitgever:Springer Berlin Heidelberg
Druk:0
Inhoudsopgave
General Considerations.- Percutaneous Absorption and Conventional Penetration Enhancers.- Lipid Flow Phenomena Between Liposomes, Lipoproteins and Cell Membranes; Applications in Drug Delivery.- Basic Principles of Liposomes for Drug Use.- Chemical Aspects.- Phospholipids as Basic Ingredients.- Liposome Dermatics: Chemical Aspects of the Skin Lipid Approach.- Ceramides for Liposomes.- Liposome Phospholipids: Toxicological and Environmental Advantages.- Physico-chemical Aspects.- Liposome Production: Historic Aspects.- Rationale for the Production and Dermal Application of Lipid Vesicles.- Liposome Production: The Ethanol Injection Technique and the Development of the First Approved Liposome Dermatic.- Liposome Production: The Sizing-Up Technology Starting from Mixed Micelles and the Scaling-Up Procedure for the Topical Glucocorticoid Betamethasone Dipropionate and Betamethasone.- Properties and Characterization of Pre-Liposome Systems.- Technological Aspects.- Changes in the Structure of the Human Stratum Corneum Induced by Liposomes.- Monitoring in vivo Skin Hydration by Liposomes Using Infrared Spectroscopy in Conjunction with Tape Stripping.- Liposome Dermatics: Assessment of Long-Term Stability.- Delivery of Liposome-Encapsulated Agents to Artificial Membranes.- Topical Delivery of Liposomally Encapsulated Ingredients Evaluated by In Vitro Diffusion Studies.- Pre-Clinical Aspects: Kinetics and Toxicology.- The Fate of Liposomes in Animal Skin.- The Fate of Liposomes for Topical Use in Skin Tissue Culture.- Liposomally Encapsulated Active Ingredients Penetrate Through the Follicle.- Biodisposition of Liposome-Encapsulated Active Ingredients Applied on the Skin.- Distribution of Liposome-Encapsulated Ingredients in Human Skin Ex Vivo.- Liposomes as Safe Carriers of Drugs and Vaccines.- Pre-Clinical Aspects: Dynamics.- Comedolytic Activity of a Liposomal Antiacne Drug in an Experimental Model.- Topical Delivery of Liposomally Encapsulated Interferon Evaluated by in Vitro Diffusion Studies and in a Cutaneous Herpes Guinea Pig Model.- Comparative Activity of a Liposomal and a Conventional Econazole Preparation for Topical Use According to a Guinea Pig Tinea Model.- Liposome-Encapsulated Enzymes for DNA Repair.- Patent and Regulatory Aspects.- General Remarks on Patent Matter.- Liposome Determatics to Come According to the Patent Literature.- Clinical Regulatory Aspects of Topical Liposomal Drugs with Special Consideration of Safety Aspects.- Clinical Aspects.- Clinical Trial Protocols for Anti-Inflammatory and other Liposome Dermatics.- Chemical Composition of Liposomes and Its Influence on the Humidity of Normal Skin.- Influence of Various Topical Liposome Preparations With and Without Active Ingredients on the Cutaneous Blood Flow.- Increased Activity and Tolerability of a Conventional Glucocorticoid in a Liposomal Form.- Influence of Liposomal Encapsulation on the Activity of a Herbal Non-Steroidal Anti-Inflammatory Drug.- Future Prospects.- Past, Present and Future of Liposome Cosmetics.- Liposomes in Drug Delivery: Present and Future.