<div>1. ISOTT from the Beginning: A Tribute to Our Deceased Members (Icons)</div><div>D. F. Bruley and E. E. Thiessen</div><div><br></div><div>Part I Cell Metabolism, Tissue Oxygenation and Treatment</div><div><br></div><div>2. A Compelling Case for the Use of Perioperative Zymogen Protein C for Increased Patient Safety </div><div>D. F. Bruley, J. M. Abdallah, M. B. Streiff, T. W. McGuire, K. C. Bruley, M. Duncan, R. Duncan, E. E. Thiessen, M. White, K. C. Bruley, Jr., and S. B. Bruley</div><div><br></div><div>3. Clinical Evaluation of MP4CO: A Phase 1b Escalating-dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease </div><div>Peter E. Keipert</div><div><br></div><div>4. Protective Effect of Dl-3-n-butylphthalide on Recovery from Cardiac Arrest and Resuscitation in Rats </div><div>Le Zhang, Michelle A. Puchowicz, Joseph C. LaManna, and Kui Xu</div><div><br></div><div>5. Hypoxia-Induced Let-7d Has a Role in Pericyte Differentiation </div><div>Nilufer Esen, Anuush Vejalla, Rakhi Sharma, Jesse S. Treuttner, and Paula Dore-Duffy</div><div><br></div><div>6. Magnification of Cholesterol-Induced Membrane Resistance on the Tissue Level: Implications for Hypoxia </div><div>Ryan Shea, Casey Smith, and Sally C. Pias</div><div><br></div><div>7. Respiratory Pores on Ostrich Struthio camelus (Aves: Struthionidae) Eggshells </div><div>T. Koyama and A.J.D. Tennyson </div><div><br></div><div>8. Evaluation of both Free Radical Scavenging Capacity and Antioxidative Damage Effect of Polydatin </div><div>Ju Jin, Yan Li, Xiuli Zhang, Tongsheng Chen, Yifei Wang, and Zhiping Wang</div><div><br></div><div>9. Spectroscopic Studies on the Interaction of Pyridinoline Cross-linking in Type 1 Collagen with ZIF8-HB </div><div>Yashun Chen, Fangfang He, Wei Liu, and Jucheng Zhang</div><div><br></div><div>10. The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases </div><div>Heping Yan, Yashun Chen, Jucheng Zhang, Wei Liu, and Rui Chen</div><div><br></div><div>Part II Cancer Oxygenation and Metabolism</div><div><br></div><div>11. Tumor Hypoxia: Causative Mechanisms, Microregional Heterogeneities, and the Role of Tissue-based Hypoxia Markers </div><div>Peter Vaupel and Arnulf Mayer</div><div><br></div><div>12. Molecular Imaging of Tumor Hypoxia: Existing Problems and Their Potential Model-based Solutions </div><div>Kuangyu Shi, Sibylle I. Ziegler, and Peter Vaupel</div><div><br></div><div>13. Direct and Repeated Clinical Measurements of pO2 for Enhancing Cancer Therapy and Other Applications </div><div>Harold M. Swartz, Benjamin B. Williams, Huagang Hou, Nadeem Khan, Lesley A. Jarvis, Eunice Y. Chen, Philip E. Schaner, Arif Ali, Bernard Gallez, Periannan Kuppusamy, and Ann B. Flood</div><div><br></div><div>14. Impact of the Tumor Microenvironment on the Expression of Inflammatory Mediators in Cancer Cells </div><div>A. Riemann, A. Ihling, S. Reime, M. Gekle, and O. Thews</div><div><br></div><div>15. Comparing the Effectiveness of Methods to Measure Oxygen in Tissues for Prognosis and Treatment of Cancer </div><div>Ann Barry Flood, Victoria A. Satinsky, and Harold M. Swartz</div><div><br></div><div>16. Potential Indexing of the Invasiveness of Breast Cancer Cells by their Mitochondrial Redox Ratios</div><div>Nannan. Sun, He N. Xu, Qingming. Luo, and Lin Z. Li</div><div><br></div><div>17. Directional Migration of MDA-MB-231 Cells under Oxygen Concentration Gradients</div><div>D. Yahara, T. Yoshida, Y. Enokida, and E. Takahashi</div><div><br></div><div>18. Stress-induced Stroke and Stomach Cancer: Sex Differences in Oxygen Saturation </div><div>Maria Ulanova, Artem Gekalyuk, Ilana Agranovich, Victoria Rezunbaeva, Ekaterina Borisova, Aly Esmat Sharif, and Oxana Semyachkina-Glushkovskaya</div><div><br></div><div>Part III Brain Oxygenation and Function</div><div><br></div><div>19. Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants</div><div>Alexander Caicedo, Liesbeth Thewissen, Anne Smits, Gunnar Naulaers, Karel Allegaert, and Sabine Van Huffel</div><div><br></div><div>20. Effects of Positive and Negative Mood Induction on the Prefrontal Cortex Activity measured by Near Infrared Spectroscopy </div><div>A. Compare, A. Brugnera, R. Adorni, and K. Sakatani</div><div><br></div><div>21. Correlation between the Cerebral Oxyhaemoglobin Signal and Physiological Signals during Cycling Exercise: A Near-Infrared Spectroscopy Study </div><div>Atsuhiro Tsubaki, Haruna Takai, Keiichi Oyanagi, Sho Kojima, Yuta Tokunaga, Shota Miyaguchi, Kazuhiro Sugawara, Daisuke Sato, Hiroyuki Tamaki, and Hideaki Onishi</div><div><br></div><div>22. Effect of Locomotor Respiratory Coupling Induced by Cortical Oxygenated Hemoglobin Levels during Cycle Ergometer Exercise of Light Intensity </div><div>Keiichi Oyanagi, Atsuhiro Tsubaki, Yuichi Yasufuku, Haruna Takai, Takeshi Kera, Akira Tamaki, Kentaro Iwata, and Hideaki Onishi</div><div><br></div><div>23. Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms </div><div>Oxana Semyachkina-Glushkovskaya, Ekaterina Borisova, Anton Namikin, Ivan Fedosov, Arkady Abdurashitov, Ekaterina Zhinchenko, Artem Gekalyuk, Maria Ulanova, Victoria Rezunbaeva, Latchezar Avramov,Dan Zhu, Qingming Luo, and Valery Tuchin</div><div><br></div><div>24. Interrelationship between Broadband NIRS Measurements of Cerebral Cytochrome C Oxidase and Systemic Changes Indicates Injury Severity in Neonatal Encephalopathy</div><div>Gemma Bale, Subhabrata Mitra, Isabel de Roever, Marcus Chan, Alexander Caicedo-Dorado, Judith Meek, Nicola Robertson, and Ilias Tachtsidis</div><div><br></div><div>25. PFC Activity Pattern during Verbal WM Task in Healthy Male and Female Subjects: A NIRS Study</div><div>Chenyang Gao, Lei Zhang, Dewu Luo, Dan Liu, and Hui Gong</div><div><br></div><div>26. Spatial Distribution of Changes in Oxidised Cytochrome C Oxidase during Visual Stimulation using Broadband Near Infrared Spectroscopy Imaging </div><div>P. Phan, D. Highton, S. Brigadoi, I. Tachtsidis, M. Smith, and C.E. Elwell</div><div><br></div><div>27. Effects of Physical Exercise on Working Memory and Prefrontal Cortex Function in Post-Stroke Patients </div><div>M. Moriya, C. Aoki, and K. Sakatani</div><div><br></div><div>28. Relation between Prefrontal Cortex Activity and Respiratory Rate during Mental Stress Tasks: A Near-Infrared Spectroscopic Study </div><div>Yuta Murayama, Lizhen Hu, Kaoru Sakatani</div><div></div><div>29. Effects of Antioxidant Supplements (BioPQQTM) on Cerebral Blood Flow and Oxygen Metabolism in the Prefrontal Cortex </div><div>Masahiko Nakano, Yuta Murayama, Lizhen Hu, Kazuto Ikemoto, Tatsuo Uetake, and Kaoru Sakatani</div><div><br></div><div>30. Temporal Comparison between NIRS and EEG Signals during a Mental Arithmetic Task Evaluated with Self-Organizing Maps </div><div>Katsunori Oyama and Kaoru Sakatani</div><div><br></div><div>31. The Role of Phonological Processing in Semantic Access of Chinese Characters: A Near-Infrared Spectroscopy Study </div><div>Jinyan Sun, Linshang Rao, Chenyang Gao, Lei Zhang, Lan Liang, and Hui Gong</div><div><br></div><div>32. Improvement of Impaired Cerebral Microcirculation using Rheological Modulation by Drag-Reducing Polymers </div><div>D.E. Bragin, Z. Peng, O.A. Bragina, G.L. Statom, M.V. Kameneva, and E.M. Nemoto</div><div><br></div><div>33. Relationship between Cerebral Oxygenation and Metabolism during Rewarming in Newborn Infants after Therapeutic Hypothermia following Hypoxic-ischemic Brain Injury</div><div>Subhabrata Mitra, Gemma Bale, Judith Meek, Cristina Uria-Avellanal, Nicola J Robertson and Ilias Tachtsidis</div><div><br></div><div>Part IV Muscle Oxygenation and Sport Medicine</div><div><br></div><div>34. Low Volume Aerobic Training Heightens Muscle Deoxygenation in Early Post-Angina Pectoris Patients </div><div>Shun Takagi, Norio Murase, Ryotaro Kime, Masatsugu Niwayama, Takuya Osada, and Toshihito Katsumura</div><div><br></div>35. The Effects of Passive Cycling Exercise for Twenty Minutes on Cardiorespiratory Dynamics in Healthy Men <div>Sayuri Fuse, Ryotaro Kime, Takuya Osada, Norio Murase, and Toshihito Katsumura</div><div><br></div><div>36. Regional Differences of Metabolic Response during Dynamic Incremental Exercise by 31P- CSI</div><div>Yasuhisa Kaneko, Ryotaro Kime, Yoshinori Hongo, Yusuke Ohno, Ayumi Sakamoto and Toshihito Katsumura</div><div><br></div><div>37. Muscle Deoxygenation and Its Heterogeneity Changes after Endurance Training </div><div>Ryotaro Kime, Masatsugu Niwayama, Yasuhisa Kaneko, Shun Takagi, Sayuri Fuse, Takuya Osada, Norio Murase, and Toshihito Katsumura</div><div><br></div><div>38. Response of BAX, Bcl-2 Proteins, and SIRT1/PGC-1α mRNA Expression to 8-Week Treadmill Running in the Aging Rat Skeletal Muscle </div><div>Fang-Hui Li, Hai-Tao Yu, Lin Xiao, and Yan-Ying Liu </div><div><br></div><div>39. Muscle Oxygen Dynamics during Cycling Exercise in Angina Pectoris Patients </div><div>Shun Takagi, Norio Murase, Ryotaro Kime, Masatsugu Niwayama, Takuya Osada, and Toshihito Katsumura</div><div><br></div><div>Part V Acupuncture, Meridians, and Primo Vascular System</div><div><br></div><div>40. Chronological Review on Scientific Findings of Bonghan System and Primo Vascular System</div><div>Kyung A Kang</div><div><br></div><div>41. Temporal Change of Alcian Blue-Stained Primo Vascular System in Lymph Vessels of Rat</div><div>Jungdae Kim, Dong-Hyun Kim, Sharon Jiyoon Jung, and Kwang-Sup Soh</div><div><br></div><div>42. Ultrastructure of the Subcutaneous Primo-vascular System in Rat Abdomen </div><div>Chae Jeong Lim, So Yeong Lee, and Pan Dong Ryu</div><div><br></div><div>43. Effects of Acupuncture Stimulation on Muscle Tissue Oxygenation at Different Points</div><div>Yasuhisa Kaneko, Ryotaro Kime, Eiji Furuya, Ayumi Sakamoto, and Toshihito Katsumura</div><div><br></div><div>Part VI Technologies and Modeling</div><div><br></div><div>44. Comparison of CWS and Diffusion Theory for Quantification of Optical Properties: Fitting with Multi-Distance vs Multi-Wavelength Data <div>Yung-Chi Lin, Zhi-Fong Lin, Shoko Nioka, Li-Hsin Chen, Sheng-Hao Tseng, and Pau-Choo Chung</div><div><br></div><div>45. Multi-modality Optical Imaging of Rat Kidney Dysfunction: In vivo Response to Various Ischemia Times </div><div>Zhenyang Ding, Lily Jin, Hsing-Wen Wang, Qinggong Tang, Hengchang Guo, and Yu Chen</div><div><br></div><div>46. Skeletal Muscle Oxygenation Measured by EPR Oximetry using a Highly Sensitive Polymer-encapsulated Paramagnetic Sensor </div><div>H. Hou, N. Khan, M. Nagane, S. Gohain, E. Y. Chen, L. A. Jarvis, P. E. Schaner, B. B. Williams, A. B. Flood, H. M. Swartz, and P. Kuppusamy</div><div><br></div><div>47. Determination of Optical and Microvascular Parameters of Port Wine Stains Using Diffuse Reflectance Spectroscopy </div><div>Zhihai Qiu, Guangping Yao, Defu Chen, Ying Wang, Ying Gu, and Buhong Li</div><div><br></div><div>48. EPR Oximetry for Investigation of Hyperbaric O2 Pre-treatment for Tumor Radiosensitization</div><div>Benjamin B. Williams, Huagang Hou, Rachel Coombs, and Harold M. Swartz</div><div><br></div><div>49. Design of a Compact, Bimorph Deformable Mirror-based Adaptive Optics Scanning Laser Ophthalmoscope </div><div>Yi He, Yuanyuan Wang, Ling Wei, Xiqi Li, Jinsheng Yang, Guohua Shi, and Yudong Zhang</div><div><br></div><div>50. Development of Portable, Wireless and Smartphone Controllable Near-Infrared Spectroscopy System </div><div>Takashi Watanabe, Rui Sekine, Toshihiko Mizuno, and Mitsuharu Miwa</div><div><br></div><div>51. Monitoring the Oxygen Dynamics of Brain Tissue in vivo by Fast Acousto-Optic Scanning Microscopy: A Proposed Instrument </div><div>Zhenqiao Zhou, Dayu Chen, Zhiqiang Huang, Shaofang Wang, and Shaoqun Zeng</div><div><br></div><div>52. Magnetization Transfer MRI Contrast May Correlate with Tissue Redox State in Prostate Cancer</div><div>Rongwen Tain, He N. Xu, Xiaohong J. Zhou, Lin Z. Li, and Kejia Cai</div><div><br></div><div>53. Comparison of Two Algorithms for Analysis of Perfusion Computed Tomography Data for Evaluation of Cerebral Microcirculation in Chronic Subdural Hematoma </div><div>Alexey O. Trofimov, George Kalentiev, Oleg Voennov, Michail Yuriev, Darya Agarkova, Svetlana Trofimova, and Denis E. Bragin</div><div><br></div><div>54. MMP-14 Triggered Fluorescence Contrast Agent </div><div>Mai-Dung Nguyen and Kyung A. Kang</div><div><br><<div>55. Boundary Element Method for Reconstructing Absorption and Diffusion Coefficients of Biological Tissues in DOT/MicroCT Imaging </div><div>Wenhao Xie, Yong Deng, Lichao Lian, Dongmei Yan, Xiaoquan Yang, and Qingming Luo</div><div><br></div><div>56. Mathematical Model of an Innate Immune Response to Cutaneous Wound in the Presence of Local Hypoxia </div><div>Guennadi Saiko, Karen Cross, and Alexandre Douplik</div><div><br></div><div>57. Analytical Expression for the NO Concentration Profile Following NONOate Decomposition in the Presence of Oxygen </div><div>Zimei Rong and Zhihui Ye</div><div><br></div></div></div>