<div>Part 1 Epidemiology</div><div><br/></div><div>Chapter 1 Environmental Factors in the Epidemiology of Inflammatory Bowel Disease</div><div>Morten H. Vatn</div><div><br/></div><div>Part 2 Immunobiology</div><div><br/></div><div>Chapter 2 The Intestinal Immune System in Health</div><div>Per Brandtzaeg </div><div><br/></div><div>Chapter 3 Understanding the Epithelial Barrier in Inflammatory Bowel Disease</div><div>Matthew A. Odenwald, Jerrold R. Turner</div><div><br/></div><div>Chapter 4 Intestinal Microbiology and Ecology in Crohn's Disease and Ulcerative Colitis</div><div>Dirk Haller, Ludovica F. Butto</div><div><br/></div><div>Chapter 5 The Immune System in Inflammatory Bowel Disease: Antimicrobial Peptides</div><div>Charles L. Bevins</div><div><br/></div><div>Chapter 6 Vascular Responses to Intestinal Inflammation</div><div>D. Neil Granger, Norman R. Harris</div><div><br/></div><div>Chapter 7 Immunobiology of Human Dendritic Cells in Inflammatory Bowel Disease</div><div>Daniel C. Baumgart</div><div><br/></div><div>Chapter 8 Immunobiology of T-Cells in Inflammatory Bowel Disease<div>S. Snapper, D. Nguyen, A Biswas</div><div><br/></div><div>Chapter 9 Immunobiology of B cells in Inflammatory Bowel Disease</div><div>Atsushi Mizoguchi, Atul K. Bhan</div><div><br/></div><div>Chapter 10 Immune Cells: Monocytes and Macrophages</div><div>Gerhard Rogler</div><div><br/></div><div>Chapter 11 Immune Functions of Epithelial Cells in Inflammatory Bowel Disease</div><div>Eric L. Campbell, Sean P. Colgan</div><div><br/></div><div>Chapter 12 Autophagy and Endoplasmic Reticulum Stress</div><div>Arthur Kaser</div><div><br/></div><div>Chapter 13 Matrix Metalloproteinases</div><div>Paolo Biancheri, Thomas T. MacDonald</div><div><br/></div><div>Chapter 14 Paradigm of T-cell Differentiation in Inflammatory Bowel Disease</div><div>Takashi Nagaishi, Mamoru Watanabe</div><div><br/></div><div>Chapter 15 Pharmacological Intervention Studies Using Mouse Models of Chronic Intestinal Inflammation</div><div>Cynthia Reinoso Webb, Matthew B. Grisham</div><div><br/></div><div>Chapter 16 Stem Cells and Organoids to Study Epithelial Cell Biology in Inflammatory Bowel Disease</div><div>Jorge O. Múnera, James M. Wells</div><div><br/></div><div>Part 3 Diagnostic Approach</div><div><br/></div><div>Chapter 17 Enhanced Endoscopy</div><div>Ralf Kiesslich</div><div><br/></div><div>Chapter 18 Magnetic Resonance Enterography</div><div>Patrik Rogalla, Luis Guimaraes</div><div><br/></div><div>Chapter 19 Computed Tomography Enterography and Inflammatory Bowel Disease</div><div>J. G. Fletcher</div><div><br/></div><div>Chapter 20 Ultrasound in Inflammatory Bowel Disease</div><div>A. Potthoff, C. Agné, M. Gebel</div><div><br/></div><div>Chapter 21 Laboratory Evaluation, Including Novel Diagnostic Markers</div><div>M. Flamant, X. Roblin</div><div><br/></div><div>Chapter 22 Pathology of Inflammatory Bowel Disease</div><div>Nora E. Joseph, Christopher R. Weber</div><div><br/></div><div>Chapter 23 Objective Assessment of Clinical Disease Activity</div><div>Edouard Louis, Catherine Van Kemseke, Catherine Reenaers</div><div><br/></div><div>Chapter 24 Objective Assessment of Endoscopic Disease Activity and Mucosal Healing</div><div>Britt Christensen, David T. Rubin</div><div><br/></div><div>Chapter 25 Evaluation of Quality of Life in Crohn's disease and Ulcerative Colitis: What Is Health-Related Quality of Life?</div><div>Katrine Carlsen, Pia Munkholm, Johan Burisch</div><div><br/></div><div>Chapter 26 Evaluation of Health Economics in Inflammatory Bowel Disease</div><div>Reena Khanna, Brian G. Feagan</div><div><br/></div><div>Part 4 Therapy Crohn’s Disease</div><div><br/></div><div>Chapter 27 The Natural History of Inflammatory Bowel Disease</div><div>Charles N. Bernstein</div><div><br/></div><div>Chapter 28 Conventional Medica Management of Crohn's Disease: Sulfasalazine</div><div>Miquel A. Gassull, Eduard Cabré</div><div><br/></div><div>Chapter 29 Steroid Therapy for Crohn's Disease</div><div>A. Hillary Steinhart</div><div><br/></div><div>Chapter 30 Thiopurines in Crohns' disease </div><div>Adi Lahat, Rami Eliakim</div><div><br/></div><div>Chapter 31 Conventional Medical Management of Crohn's Disease: Methotrexate</div><div>Grace Harkin, Laurence Egan</div><div><br/></div><div>Chapter 32 Adalimumab for the Treatment of Crohn’s Disease </div><div>Remo Panaccione</div><div><br/><div>Chapter 33 Biologic Therapy of Crohn's Disease: Certolizumab</div><div>Alessandro Armuzzi, Daniela Pugliese</div><div><br/></div><div>Chapter 34 Biologic Therapy of Crohn's Disease: Infliximab</div><div>Jan-Michael A. Klapproth, Gary R. Lichtenstein</div><div><br/></div><div>Chapter 35 Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease Treatment</div><div>Peter J. Mannon</div><br/></div><div>Chapter 36 Biologic Therapy of Crohn's Disease: Natalizumab, Vedolizumab and anti-MadCAM</div><div>Pieter Hindryckx, Geert D’Haens</div><div><br/></div><div>Chapter 37 Optimal Management of Fistulizing Crohn's Disease</div><div>Bruce Sands, Farhad Peerani</div><div><br/></div><div>Part 5 Therapy Ulcerative Colitis</div><div><br/></div><div>Chapter 38 Sulfasalazine and 5-Aminosalicylates for Ulcerative Colitis</div><div>Reena Khanna, John K. Marshall </div><div><br/></div><div>Chapter 39 Conventional Therapy of Ulcerative Colitis: Corticosteroids</div><div>Kirstin Taylor, Peter R. Gibson</div><div><br/></div><div>Chapter 40 Medical Management of Ulcerative Colitis: Conventional Therapy--Azathioprine</div><div>Barrett G. Levesque, Edward V. Loftus</div><div><br/></div><div>Chapter 41 Calcineurin Inhibitors in Ulcerative Colitis</div><div>Andreas Fischer, Daniel C. Baumgart</div><div><br/></div><div>Chapter 42 Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab</div><div>Mindy Lam, Brian Bressler</div><div><br/></div><div>Chapter 43 Biologic Therapy of Ulcerative Colitis: Adalimumab</div><div>Walter Reinisch</div><div><br/></div><div>Chapter 44 Biologic Therapy of Ulcerative Colitis: Golimumab</div><div>Mark A. Samaan, Peter M. Irving</div><div><br/></div><div>Chapter 45 Biologic Therapy of Ulcerative Colitis: Natalizumab, Vedolizumab, Etrolizumab (rHUMab beta 7), antiMadCAM</div><div>Severine Vermeire </div><div><br/></div><div>Chapter 46 Probiotics, Prebiotics, and Antibiotics in Inflammatory Bowel Disease</div><div>Paolo Gionchetti, Carlo Calabrese, Andrea Calafiore, Fernando Rizzello</div><div><br/></div><div>Chapter 47 Biosimiliars in the Treatment of Inflammatory Bowel Disease</div><div>Vivian W. Huang, Richard N. Fedorak</div><div><br/></div><div>Chapter 48 Step-up vs. Top-down Approach in Crohn’s Disease</div><div>Christine Y. Yu, Daniel W. Hommes</div><div><br/><div>Chapter 49 Leucocytapheresis Therapy of Inflammatory Bowel Disease</div><div>Takanori Kanai</div><div><br/></div><div>Chapter 50 Surgical Management of Crohn's Disease and Ulcerative Colitis</div><div>Robert R. Cima, John H. Pemberton</div><div><br/></div><div>Part 6 Extraintestinal Manifestations </div><div><br/></div><div>Chapter 51 Extraintestinal Manifestations: Autoimmune Hepatitis</div><div>Michael Manns, Nora Schweitzer</div><div><br/></div><div>Chapter 52 Primary Sclerosing Cholangitis</div><div>Roger W. Chapman, Kate D. Williamson</div><div><br/></div><div>Chapter 53 Autoimmune Pancreatitis and Other Organ Involvement</div><div>Go Kuwata, Terumi Kamisawa</div><div><br/></div><div>Chapter 54 Cutaneous and Oral Manifestations of Inflammatory Bowel Disease</div><div>Caroline P. Allen, Susan M. Burge </div><div><br/></div><div>Chapter 55 Arthritis, Arthropathy and Osteoporosis in Inflammatory Bowel Disease</div><div>Alistair Tindell, Hanna Johnsson, Iain B. McInnes</div><div><br/></div><div>Part 7 Nutrition</div><div><br/></div><div>Chapter 56 Nutrition in Inflammatory Bowel Disease</div><div>Alan L. Buchman</div><div><br/></div><div>Part 8 Pregnancy, Family Planning and Pediatric Aspects</div><div><br/></div><div>Chapter 57 Pregnancy and Fertility in Inflammatory Bowel Disease</div><div>Rebecca Matro, Uma Mahadevan</div><div><br/></div><div>Chapter 58 Pediatric Aspects of Inflammatory Bowel Disease</div><div>Brendan Boyle, Jeffrey S. Hyams</div><div><br/></div><div>Part 9 Surveillance and Prevention</div><div><br/></div><div>Chapter 59 Management and Prevention of Infectious Diseases in Irritable Bowel Disease Patients</div><div>Kristine Macartney, Nigel Crawford</div><div><br/></div><div>Chapter 60 Incidence of Cancer and Screening in Inflammatory Bowel Disease</div><div>Jimmy K. Limdi, Francis A. Farraye</div><div><br/></div><div>Chapter 61 Inflammatory Bowel Diseases: How to Identify High Risk Patients</div><div>Jacques Cosnes, Harry Sokol </div><div><br/></div><div>Part 10 Patient Perspective and Resources</div><div><br/></div><div>Chapter 62 Patient Perspective on Inflammatory Bowel Disease</div><div>Ayesha Williams, Marjorie Merrick</div><div><br/><div>Chapter 63 Patient Resources in Inflammatory Bowel Disease</div><div>Sanna Lönnfors, Marco Greco</div><div> </div></div></div></div>