Chronic Lymphocytic Leukemia

Pathobiology, B Cell Receptors, Novel Mutations, Clonal Evolution

Specificaties
Gebonden, blz. | Engels
Springer International Publishing | e druk, 2018
ISBN13: 9783319706023
Rubricering
Springer International Publishing e druk, 2018 9783319706023
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for pathologists and clinical hematologists/oncologists with an interest in chronic lymphocytic leukemia. This book is designed to provide a concise yet comprehensive summary of the traditional and new definitions, prognostic markers, the pathobiology and newer hierarchal classification based on molecular genetics/chromosomal abnormalities.  It will include the most up-to-date scientific and clinical information and bring together subject matter that is usually covered separately in various specialties of hematopathology, molecular pathology, basic science and immunology. The book is written in an easy to comprehend format with emphasis on the science and illustrations to explain the same. It is therefore intended to intrigue, the junior resident and the senior pathologists/clinical oncologists and anyone who would like to keep up with this rapidly growing field.

Specificaties

ISBN13:9783319706023
Taal:Engels
Bindwijze:gebonden
Uitgever:Springer International Publishing

Inhoudsopgave

Definition, Epidemiology, Monoclonal B cell lymphocytosis, Morphology , Immunophenotype, Transformation, Gene expression profiling.- Chromosomal aberrations in CLL :Karyotype and FISH.- B cell receptors (BCRs).- Novel mutations in CLL.- Clonal evolution and the Driver/Passenger Mutation Model in CLL.- Prognosis and predictive factors - Hierarchal classification.- MiRNAs.

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        Chronic Lymphocytic Leukemia