<div>1. Introduction and epidemiology of meningococcal disease</div><div>Neisseria meningitidis </div><div>Disease surveillance </div><div>Case fatality and sequelae </div><div>Epidemiology of meningococcal disease </div><div>Capsular groups causing disease </div><div>Current issues </div><div>Summary points </div><div>References </div><div><br></div><div><div>2. Carriage and transmission of Neisseria meningitidis</div><div>Introduction </div><div>Detecting the carrier state</div><div>The natural history of meningococcal carriage</div><div>Epidemiology of carriage</div><div>Other Neisseria species</div><div>Effect of vaccination on carriage</div><div>Summary points</div><div>References </div><div><br></div><div><div>3. Pathogenesis of invasive disease</div><div>Introduction</div><div>Transmission, adaptation, and penetration to the circulation</div><div>Neisseria meningitidis and intravascular survival</div><div>Meningococcemia: a disease of the endothelial cells</div><div>Pathophysiological characteristics of clinical presentations of meningococcal disease</div></div><div><div>The immune response</div><div>Summary points</div><div>References</div></div><div><br></div><div><div>4. Diagnosis of meningococcal disease</div><div>Introduction</div><div>Conventional diagnosis</div><div>Molecular diagnosis </div><div>Typing of Neisseria meningitidis</div><div>Summary and future outlook</div><div>References</div></div><div><br></div><div><div>5. Clinical aspects of meningococcal disease</div><div>Introduction </div><div>Clinical spectrum of disease</div><div>Symptoms of disease</div><div>Disease outcomes and prognosis </div><div>Raising awareness of disease </div><div>Genetic factors </div><div>Summary points </div><div>References</div></div><div><br></div><div><div>6. Treatment of meningococcal disease</div><div>Introduction</div><div>Shock</div><div>Raised intracranial pressure</div><div>Antibiotic therapy</div><div>Adjunctive therapies </div><div>Where to manage children with meningococcal disease? </div><div>Summary points </div><div>References</div><div><br></div><div><div>7. Prevention of meningococcal disease through vaccination</div><div>Introduction </div><div>Polysaccharide vaccines </div><div>Protein-polysaccharide conjugate vaccines </div><div>Production and quality control of polysaccharide and conjugate vaccines</div><div>Immunological correlates of protection </div><div>Capsular group B vaccines </div><div>Summary points </div><div>References</div></div><br></div><div><div>Appendix </div><div>Management of bacterial meningitis in children and young people <br></div><div>Management of meningococcal disease in children and young people</div></div><div><div>Early management of suspected bacterial meningitis and meningococcal septicaemia in immunocompetent adults</div></div></div>