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Fc Receptors

Specificaties
Gebonden, 424 blz. | Engels
Springer International Publishing | 2014e druk, 2014
ISBN13: 9783319079103
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Springer International Publishing 2014e druk, 2014 9783319079103
€ 204,99
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Samenvatting

This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.

Specificaties

ISBN13:9783319079103
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:424
Uitgever:Springer International Publishing
Druk:2014

Inhoudsopgave

<p>Part I : Old and new FcRs </p><p> </p><p>Hiromi Kubagawa, Yoshiki Kubagawa, Dewitt Jones, Tahseen H. Nasti, Mark Walter, and Kazuhito Honjo</p><p>The Old but New IgM Fc Receptor (FcμR)</p><p> </p><p>F.J. Li, W.J. Won, E.J. Becker Jr., J.L. Easlick, E. Tabengwa, R. Li, M. Shakhmatov, P.D. Burrows, and R.S. Davis</p><p>Emerging Roles for FCRL Family Members in Lymphocyte Biology and Disease</p><p> </p><p>Leo C. James</p><p>Intracellular antibody immunity and the cytosolic Fc receptor TRIM21</p><p> </p><p> </p><p>Part II: FcR signaling</p><p> </p><p>Anna Niarakis, Yacine Bounab, Luca Grieco, Roman Roncagalli, Jérôme Garin, Bernard Malissen, Marc Daëron, Denis Thieffry</p><p>Computational modeling of the main signaling pathways involved in mast cell activation</p><p> </p><p>Tarik Attout, Andres Floto and Pierre Launay</p><p>Calcium channels in FcR signaling</p><p> </p><p>Marcel Kuhny, Carolin N. Zorn, and Michael Huber</p><p>Regulation of FcεRI signaling by lipid phosphatases</p><p> </p><p> </p><p>Part III: FcR biology</p><p> </p><p>Marc Daëron</p><p>Fc Receptors as Adaptive Immunoreceptors</p><p> </p><p>Jerrard M Hayes, Eoin FJ Cosgrave, Weston B Struwe, Mark Wormald, Gavin P. Davey, Roy Jefferis, Pauline M Rudd</p><p>Glycosylation and Fc Receptors<sup></sup></p><p> </p><p>Birgitta Heyman</p><p>Antibodies as natural adjuvants</p><p> </p><p>Sanae Ben Mkaddem, Ivy Christou, Elisabetta Rossato, Laureline Berthelot, Agnès Lehuen and Renato C. Monteiro</p><p>IgA, IgA receptors and their anti-inflammatory properties</p><p> </p><p>Stylianos Bournazos, David J. DiLillo and Jeffrey V. Ravetch</p><p>Humanized mice to study FcγR function</p><p> </p><p>Dilip K. Challa, Ramraj Velmurugan, Raimund J. Ober and E. Sally Ward</p><p>FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions.</p><p> </p><p> </p><p>Part IV: FcRs and disease</p><p> </p><p>Xinrui Li, Andrew W Gibson and Robert P Kimberly</p><p>Human FcR polymorphism and disease.</p><p> </p><p>Hanane el Bannoudi, Andreea Ioan-Facsinay and René E. M. Toes</p><p>Bridging auto-antibodies and arthritis; the role of Fc Receptors</p><p> </p><p>P. Mark Hogarth, Jessica C. Anania, Bruce D. Wines</p><p>The FcγR of humans and non-human primates and their interaction with IgG:  Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies</p><p> </p><p> </p><p>Part V: FcRs and therapeutic antibodies</p><p> </p><p>Ann L White, Stephen A Beers and Mark S. Cragg</p><p>FcgRIIB as a key determinant of agonistic antibody efficacy </p><p>               </p><p>Jantine E. Bakema and Marjolein van Egmond</p><p>Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work</p><p> </p><p>Sybille Böhm, Daniela Kao and Falk Nimmerjahn</p><p>Sweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin G</p>
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        Fc Receptors