Kenji Hashimoto,
Mario Manto
Springer International Publishing
e druk, 2022
9783030797928
New Rapid-acting Antidepressants
Specificaties
Paperback, blz.
|
Engels
Springer International Publishing |
e druk, 2022
ISBN13: 9783030797928
Rubricering
Onderdeel van serie
Contemporary Clinical Neuroscience
Levertijd ongeveer 8 werkdagen
Samenvatting
This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments.
Specificaties
ISBN13:9783030797928
Taal:Engels
Bindwijze:paperback
Uitgever:Springer International Publishing
Inhoudsopgave
(R)-ketamine: A new rapid-acting antidepressant.- (2R,6R)-hydroxynorketamine, a metabolite of ketamine: the antidepressant actions and the mechanisms.- Predictable biomarkers for rapid-acting antidepressant response to ketamine.- Nitrous Oxide: an old compound with emerging psychotropic properties.- Novel AMPA receptor potentiators TAK-137 and TAK-653 as potential rapid-acting antidepressants.- AMPA receptor potentiators as potential rapid-acting antidepressants.- mGlu2/3 receptor antagonists as rapid-acting antidepressants.- Antidepressant effects of the muscarinic receptor antagonist scopolamine: Clinical and preclinical review.