Molecular Mechanisms of Notch Signaling
Samenvatting
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression.
Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated.
This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.
Specificaties
Inhoudsopgave
<p>Contributors</p>
<p>Part 1 – Introduction</p>
1. Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis<p></p>
<p>Benedetto Daniele Giaimo and Tilman Borggrefe</p>
<p>Part 2 – Molecular mechanisms of receptor/ligand interactions</p>
<p>2. Structural insights into Notch receptor-ligand interactions</p>
<p>Penny Handford, Boguslawa Korona, Richard Suckling, Christina Redfield and Susan Lea</p>
<p>3. The Molecular Mechanism of Notch Activation</p>
<p>Klaus N. Lovendahl, Stephen C. Blacklow and Wendy R. Gordon</p>
<p>4. Regulation of Notch Function by O-Glycosylation</p>
<p>Beth M. Harvey and Robert S. Haltiwanger</p>
5. Modeling the Notch response<p></p>
<p>Udi Binshtok and David Sprinzak</p>
<p>6. Endocytic trafficking of the Notch receptor</p>
<p>Björn Schnute, Tobias Troost and Thomas Klein</p>
<p>Part 3 – Intracellular signaling mechanisms</p>
<p>7. The Notch Interactome: complexity in signaling circuitry</p>
<p>Diana M. Ho, K. G. Guruharsha and Spyros Artavanis-Tsakonas</p>
<p>8. Integration of Drosophila and Human Genetics to understand Notch signaling related diseases</p>
<p>Shinya Yamamoto and Jose L. Salazar</p>
<p>9. Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a Notch?</p>
<p>Victor Alfred and Thomas Vaccari</p>
10. The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms<p></p>
<p>Diana Bellavia, Saula Checquolo, Rocco Palermo and Isabella Screpanti</p>
<p>11. Notch and neurogenesis</p>
<p>Anna Engler, Runrui Zhang and Verdon Taylor</p>
<p>12. Notch and stem cells</p>
Anna Bigas and Cristina Porcheri<p></p>
<p>13. Oscillatory control of Notch signaling in development</p>
<p>Ryoichiro Kageyama, Hiromi Shimojo and Akihiro Isomura</p>
14. CSL-associated corepressor and coactivator complexes<p></p>
<p>Franz Oswald and Rhett A. Kovall</p>
<p>Part 4 – Disease links and therapeutics</p>
<p>15. Notch and senescence</p>
<p>Matthew Hoare and Masashi Narita</p>
16. Control of blood vessel formation by Notch signaling<p></p>
<p>Fabian Tetzlaff and Andreas Fischer</p>
<p>17. Notch and T cell function – a complex tale</p>
<p>Jyothi Vijayaraghavan and Barbara A. Osborne</p>
<p>18. Notch in leukemia</p>
<p>Anna C. Gormley, Qing Wang and Mark Chiangs</p>