New Antibiotic Targets

Biocomputational Strategies for Microbial Drug Target Identification.- Methods to Assay Inhibitors of DNA Gyrase and Topoisomerase IV Activities.- A Method to Assay Inhibitors of DNA Polymerase IIIC Activity.- Methods to Identify and Characterize Inhibitors of Bacterial RNA Polymerase.- Methods to Assay Inhibitors of tRNA Synthetase Activity.- Three Methods to Assay Inhibitors of Ribosomal Subunit Assembly.- Inhibition ofChaperone-Dependent Bacterial Ribosome Biogenesis.- Assays for the Identification of Inhibitors Targeting Specific Translational Steps.- SPARK: A New Peptidyl Transferase Activity Assay.- High-Throughput Screening of Peptide Deformylase Inhibitors.- A Method to Assay Penicillin-Binding Proteins.- A Method to Assay Inhibitors of Lipopolysaccharide Synthesis.- Methods for Assessing the Structure and Function of Cationic Antimicrobial Peptides.- Flow Cytometry of Bacterial Membrane Potential and Permeability.- Bacterial Efflux Pump Inhibitors.- Mycobacterium tuberculosis ?-Ketoacyl Acyl Carrier Protein Synthase III (mtFabH) Assay: Principles and Method.- Screening for Compounds That Affect the Interaction Between Bacterial Two-Component Signal Transduction Response Regulator Protein and Cognate Promoter DNA.- The Activity of rRNA Resistance Methyltransferases Assessed by MALDI Mass Spectrometry.- Assays for ?-Lactamase Activity and Inhibition.- Studies of Enzymes That Cause Resistance to Aminoglycosides Antibiotics.