Stem Cells Handbook
Samenvatting
The power of stem cells for tissue development, regeneration, and renewal has been well known by embryologists and developmental biologists for many years. Those presently active in research in the stem cell field owe much to previous work by embryologists and cancer researchers for their insights into what stem cells can do. In the last 4- 5 years, the rapid expansion of the concept of adult tissue stem cells as pluripotent progenitors for various tissues has led to an even greater appreciation of the power of stem cells. The demonstration that both embryonic and adult tissue stem cells have the ability to produce progenitor cells for tissue renewal has opened vast possibilities for treatment of congenital deficiency diseases as well as for regeneration of damaged tissues. Older concepts of determination leading to loss of potential during differentiation of adult tissues are being replaced by newer ideas that cells with multiple potential exist in different forms in various adult organs and that cells thought to be restricted to differentiation to one cell type may be able to "transdifferentiate" into other tissue cell types. Thus, the concept of "embryonic rests" in adult tissues, hypothesized to be the cellular origin of cancer by Durante and Conheim in the 1870s, now can be expanded to include survival of pluripotential embryonic-like stem cells in adult tissues.
Specificaties
Inhoudsopgave
Stewart Sell
Stem Cells from Early Mammalian Embryos: Common Themes and Significant Differences
Virginia E. Papaioannou and Anna-Katerina Hadjantonakis
Embryonic Stem Cells: Isolation and Application of Pluripotent Cells from the Pregastrulation Mammalian Embryo
Joy Rathjen and Peter David Rathjen
From Stem Cells to Functional Tissue Architecture: What Are the Signals and How Are They Processed?
Sui Huang and Donald E. Ingber
Germline Stem Cells
Haifan Lin
Stem Cells and Cloning
Ian Wilmut and Lesley Ann Paterson
Genomic Imprinting in Mouse Embryonic Stem and Germ Cells
Jeffrey R. Mann and Piroska E. Szabó
Stem Cells in Amphibian Regeneration
David L. Stocum
Stem Cells in Dermal Wound Healing
William J. Lindblad
Bone Marrow Mesenchymal Stem Cells
James E. Dennis and Arnold I. Caplan
Normal and Leukemic Hematopoietic Stem Cells and Lineages
Ernest A. McCulloch
Developmental Origin of Murine Hematopoietic Stem Cells
Lorraine Robb and Kyunghee Choi
Stromal Support of Hematopoiesis
Pierre Charbord
Hematopoietic Stem Cells: Identification, Characterization, and Assays
Ian Ponting, Yi Zhao and W. French Anderson
Hematopoietic Stem Cells in Leukemia and Lymphoma
Stephen M. Baird
Neurons, Stem Cells, and Potential Therapies
Fiona C. Mansergh, Michael A. Wride, and Derrick E. Rancourt
Neural Stem Cells: From In Vivo to In Vitro and Back Again-Practical Aspects
Michael A. Marconi, Kook I. Park, Yang D. Teng, Jitka Ourednik, Vaclav Ourednik, Rosanne M. Taylor, Aleksandra E. Marciniak, Marcel M. Daadi, Heather L. Rose, Erin B. Lavik, Robert Langer, Kurtis I. Auguste, Mahesh Lachyankar, Curt R. Freed, D.Eugene Redmond, Richard L. Sidman, and Evan Y. Snyder
Molecular Genetic Approaches in the Study of Retinal Progenitor Cells and Stem Cells
Till Marquardt and Peter Gruss
Endothelial Progenitor Cells
Takayuki Asahara and Jeffrey M. Isner
Development of the Cardiovascular System in Embryoid Bodies Derived from Embryonic Stem Cells
Heinrich Sauer, Maria Wartenberg, Agapios Sachinidis, and Jürgen Hescheler
Transcription Factors, Growth Factors, and Signal Cascades Capable of Priming Cardiogenesis
Agapios Sachinidis, Heinrich Sauer, Maria Wartenberg, and Jürgen Hescheler
Strategies Using Cell Therapy to Induce Cardiomyocyte Regeneration in Adults with Heart Disease
Silviu Itescu
Generation and Stem Cell Repair of Cardiac Tissues
Kathyjo A. Jackson and Margaret A. Goodell
Stem Cells in Kidney Morphogenesis
Emma M. A. Ball and Gail P. Risbridger
Nephroblastoma: A Metanephric Caricature
Alan O. Perantoni
Stem Cells in Nonmelanoma Skin Cancer
Wendy C. Weinberg and Stuart H. Yuspa
The Stem Cell Plasticity of Aggressive Melanoma Tumor Cells
Mary J. C. Hendrix, Elisabeth A. Seftor, Paul S. Meltzer, Angela R. Hess, Lynn M. Gruman, Brian J. Nickoloff, Lucio Miele, Don D. Sheriff, Gina C. Schatteman, Mario A. Bourdon, and Richard E. B. Seftor
Stem Cells in Glandular Organs
Karin Williams and Simon W. Hayward
Gastrointestinal Stem Cells: Proliferation Kinetics and Differentiation Hierarchies
Sherif M. Karam
Stem Cell Origin of Cell Lineages, Proliferative Units, and Cancer in the Gastrointestinal Tract
Mairi Brittan and Nicholas A. Wright
Specification of Liver from Embryonic Endoderm
Hideyuki Yoshitomi and Kenneth S. Zaret
Animal Models for Assessing the Contribution of Stem Cells to Liver Development
Douglas C. Hixson
Normal Liver