I: Obesity.- 1 Energy Metabolism and Obesity.- 2 Metabolic Parameters and Energy Expenditure Before and After Weight Loss.- 3 Regulation of Food Intake and Body Weight.- 4 Mechanisms of Insulin Resistance in Obesity.- 5 Effects of Obesity on Lipid Metabolism.- II: Noninsulin-Dependent Diabetes Mellitus.- 6 Genetics of Noninsulin-Dependent Diabetes Mellitus (NIDDM).- 7 Insulin Secretion in Type II Diabetes Mellitus.- 8 Insulin Action and Insulin Resistance in Noninsulin-Dependent Diabetes Mellitus.- 9 Dyslipidemia in Noninsulin-Dependent Diabetes Mellitus.- 10 Exercise and Noninsulin-Dependent Diabetes Mellitus (NIDDM).- 11 Glucose Toxicity and Insulin Resistance in NIDDM.- 12 Energy Metabolism and Sympathetic Activity in Patients with Insulin Resistance.- 13 Effects of NIDDM on Vascular Tone Regulation.- III: Insights Gained from Other Insulin-Resistance Syndromes.- 14 Insulin Resistance in the Polycystic Ovary Syndrome.- 15 Dietary Management of NIDDM.- 16 Hypertension and Insulin Resistance.- 17 Lessons Learned from Clinical and Basic Research Applied to the Study of Patients with Severe Insulin Resistance.- 18 Treatment of Obesity Through Changes in Lifestyle.- 19 Syndrome X: Past, Present, and Future.