Essentials of Apoptosis
A Guide for Basic and Clinical Research
Samenvatting
This is the second edition of the comprehensive, concise summary of apoptosis research. It covers the major concepts, molecular architecture, the biochemical pathways, and pathophysiological significance of apoptosis. This book provides a guideline of standard biochemical and cell biologic approaches to apoptosis bench work with an emphasis on translational clinical applications for immune disorders, cancer research, ischemia, and neuronal degeneration. Since the original publication in 2003, the apoptosis field has expanded rapidly – chapters not only need to be revised and expanded, but there is a need for all new chapters covering exciting advances in bioinformatics, systems biology, oxidative stress, etc.
Specificaties
Inhoudsopgave
Table of Contents
Preface (2nd edition)
Preface (1st edition)
Contributors
Part I. Molecules and Pathways of Apoptosis
Chapter 1. Caspases: Activation, Regulation and Function
Stefan J. Riedl and Fiona L. Scott
Chapter 2. Bcl-2 Family Proteins
Wenxing Ding and Xiao-Ming Yin
Chapter 3. The Mammalian IAPs: Multi-faceted Inhibitors of Apoptosis
Eric C. LaCasse, Herman H. Cheung, Allison M. Hunter, Stephanie Plenchette, Douglas J. Mahoney and Robert G. Korneluk
Chapter 4. Structure Biology of Programmed Cell Death
Yigong Shi
Chapter 5. The Death Receptor Pathway
Maria Eugenia Guicciardi and Gregory J. Gores
Chapter 6. The Mitochondrial Pathway: Focus on Shape Changes
Silvia Campello and Luca Scorrano
Chapter 7. The Endoplasm Reticulum Pathway
Michael W. Harr and Clark W. Distelhorst
Chapter 8. Reactive Oxygen Species in Cell Fate Decisions
Han-Ming Shen and Shazib Pervaiz
Chapter 9. The Integration of Metabolism and Cell Death
Jonathan L. Coloff, Yuxing Zhao and Jeffrey C. Rathmell
Chapter 10. Transcriptional Regulation of Apoptosis
Crissy Dudgeon, Wei Qiu, Quanhong Sun, Lin Zhang and Jian Yu
Chapter 11. Clearance of Apoptotic cells --Mechanisms and Consequences
Carylin J. Marek and Lars-Peter Erwig
Chapter 12. Systems Biology Approach to the Study of Apoptosis
Heinrich Huber, Eric Bullinger and Markus Rehm
Part II: Apoptosis in Model Organisms
Chapter 13. Programmed Cell Death in Plants: Apoptotic but not Quite
Naohide Watanabe and Eric Lam
Chapter 14. Tracing the Roots of Death: Apoptosis in Saccharomyces cerevisiae
Didac Carmona-Gutierrez and Frank Madeo
Chapter 15. Programmed Cell Death in C. elegans.
Monica Darland-Ransom, Yi-Chun Wu and Ding Xue
Chapter 16. Cell Death in Drosophila.
Dianne C. Purves, Jessica P. Monserrate and Carrie Baker Brachmann
Part III. Apoptosis in Mammalian Physiology and Pathogenesis
Chapter 17. Cell Death: Defining and Misshaping Mammalian Embryos
Zahra Zakeri and Richard Lockshin
Chapter 18. Matters of Life and Death in the Immune System
Christopher Dillon and Douglas R. Green
Chapter 19.Cell Death in the Hematopoietic System
Emma C. Josefsson and Benjamin T. Kile
Chapter 20 Cell Death in Acute Neuronal Injury
R. Anne Stetler, Armando P. Signore and Jun Chen
Chapter 21. Apoptosis in Neurodegenerative Diseases
Qiuli Liang and Jianhua Zhang
Chapter 22. Apoptosis in Cardiovascular Pathogenesis
Hamid el Azzouzi; Meriem Bourajjaj; Paula A. da Costa Martins and Leon J. De Windt
Chapter 23. Apoptosis in Lung Injury and Disease
Stefan W. Ryter, Hong Pyo Kim, and Augustine M. K. Choi
Chapter 24. Apoptosis in the Liver Injury and Liver Diseases
Yosuke Osawa, Ekihiro Seki, and David A Brenner
Chapter 25. Apoptosis in Kidney Injur