Liposomes
Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers
Samenvatting
Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that “the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer” [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.
Specificaties
Inhoudsopgave
Tamer A. ElBayoumi and Vladimir P. Torchilin
2. Nanoliposomes: Preparation and Analysis
M. Reza Mozafari
3. Preparation of DRV Liposomes
Sophia G. Antimisiaris
4. Elastic Liposomes for Topical and Transdermal Drug Delivery
Heather A.E. Benson
5. Archaebacterial Tetraetherlipid Liposomes
Aybike Ozcetin, Samet Mutlu, and Udo Bakowsky
6. Cationic Magnetoliposomes
Marcel De Cuyper and Stefaan J.H. Soenen
7. Ultrasound-Responsive Liposomes
Shao-Ling Huang
8. Liposome Formulations of Hydrophobic Drugs
Reto A. Schwendener and Herbert Schott
9. Remote Loading of Anthracyclines into Liposomes
Felicitas Lewrick and Regine Peschka-Süss
10. Arsonoliposomes: Preparation and Physicochemical Characterization
Sophia G. Antimisiaris and Panayiotis V. Ioannou
11. Liposome-Based Vaccines
Reto A. Schwendener, Burkhard Ludewig, Andreas Cerny, and Olivier Engler
12. Mannosylated Liposomes for Targeted Vaccines Delivery
Suresh Prasad Vyas, Amit K. Goyal, and Kapil Khatri
13. Liposomes for Specific Depletion of Macrophages from Organs and Tissues
Nico van Rooijen and Esther Hendrikx
14. Vesicular Phospholipid Gels
Martin Brandl
15. Environment-Responsive Multifunctional Liposomes
Amit A. Kale and Vladimir P. Torchilin
16. Functional Liposomal Membranes for Triggered Release
Armagan Koçer
17. A 'Dock and Lock' Approach to Preparation of Targeted Liposomes
Marina V. Backer and Joseph M. Backer
18. Conjugation of Ligands to the Surface of Preformed Liposomes by Click Chemistry
Benoît Frisch, Fatouma Saïd Hassane, and Francis Schuber
19. Targeted MagneticLiposomes Loaded with Doxorubicin
Pallab Pradhan, Rinti Banerjee, Dhirendra Bahadur, Christian Koch, Olga Mykhaylyk, and Christian Plank
20. Liposomes for Drug Delivery to Mitochondria
Sarathi V. Boddapati, Gerard G.M. D’Souza, and Volkmar Weissig
21. Cytoskeletal-Antigen Specific Immunoliposomes: Preservation of Myocardial Viability
Vishwesh Patil, Tala Khudairi, and Ban-An Khaw
22. Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes
Suna Erdogan and Vladimir P. Torchilin
23. Angiogenic Vessel-Targeting DDS by Liposomalized Oligopeptides
Tomohiro Asai and Naoto Oku
24. TAT-Peptide Modified Liposomes: Preparation, Characterization, and Cellular Interaction
Marjan M. Fretz and Gert Storm
25. ATP-Loaded Liposomes for Targeted Treatment in Models of Myocardial Ischemia
Tatyana S. Levchenko, William C. Hartner, Daya D. Verma, Eugene A. Bernstein, and Vladimir P. Torchilin
26. Intracellular ATP Delivery Using Highly Fusogenic Liposomes
Sufan Chien
27. Lipoplex Formation Using Liposomes Prepared by Ethanol Injection
Yoshie Maitani
28. Acid-Labile Liposome / pDNA Complexes
Michel Bessodes and Daniel Scherman
29. Serum-Resistant Lipoplexes in the Presence of Asialofetuin
Conchita Tros de ILarduya
30. Anionic pH Sensitive Lipoplexes
Nathalie Mignet and Daniel Scherman
31. Liposomal siRNA Delivery
Jeffrey Hughes, Preeti Yadava, and Ryan Mesaros
32. Complexation of siRNA and pDNA with Cationic Liposomes: The Important Aspects in Lipoplex Preparation
José Mario Barichello, Tatsuhiro Ishida, and Hiroshi Kiwada
33. Effective In Vitro and In Vivo Gene Delivery by The Combination of Liposomal Bubbles (Bubble Liposomes) and Ultrasound