Post-Traumatic Stress Disorder
Basic Science and Clinical Practice
Samenvatting
Post-traumatic stress disorder is a psychiatric illness that can occur in anyone who has experienced a life-threatening or violent event. The trauma can be due to war, terrorism, torture, natural disasters, violence, or rape. In PTSD the brain areas that are likely to be affected are the hippocampus (memory), amygdala (fear association), the prefrontal cortex (cognitive processing), and the ascending reticular activating system (arousal). The chemical of interest is norepinephrine, which is released during a stressful event and is part of the fight-or-flight response meant to mobilize the body to action.The objective of this title is to outline the neurobiology of post-traumatic stress disorder and provide treatment strategies for clinicians. The chapter material from this book has evolved from a seminar on PTSD held recently under the auspices of the VA Boston Healthcare System, Boston University Medical Center and Harvard Medical School. We propose a book that will focus on the epidemiology, neurobiology, MRI studies, animal models, arousal and sleep issues, clinical trials, and treatment strategies for clinicians. Treatment will cover such topics as guidelines for treating posttraumatic stress disorder, PTSD and the use of mental health services, cognitive intervention therapy, and large scale clinical trials in PTSD. This collection will be a vital source of information to clinicians and neuroscientists.
Specificaties
Inhoudsopgave
Terence M. Keane, PhD, Brian P. Marx, PhD, and Denise M. Sloan, PhD
Amygdala and Fear
Amygdala and the Neural Pathways of Fear
Jacek Debeic, MD, PhD, MPhil and Joseph E. LeDoux, MD
Physiology Of The Amygdala: Implications For Post-Traumatic Stress Disorder
Donald G Rainnie, PhD and Kerry J. Ressler, MD, PhD
Counteracting Molecular Pathways Regulating The Reduction Of Fear: Implications For The Treatment Of Anxiety Diseases
Andre Fischer, PhD and Li-Huei Tsai, MD, PhD
Memory In Post-Traumatic Stress Disorder: A Neurocognitive Approach
Mieke Verfaellie, PhD and Jennifer J. Vasterling, PhD
Animal Models of Post-Traumatic Stress Disorder
Towards Animal Models of Post-Traumatic Stress Disorder
Hagit Cohen, PhD and Gal Richter-Levin, PhD
Post-Traumatic Stress Disorder: From Neurons to Networks
Rajnish Rao, PhD, Aparna Suvrathan, Melinda M. Miller, Bruce S. McEwen, PhD, and Sumantra Chattarji, PhD
Post-Traumatic Stress Disorder and Arousal
Arousal Neurons in the Brain
Priyattam J. Shiromani, PhD and Carlos Blanco-Centurion, PhD
Hyperarousal and Post-Traumatic Stress Disorder: A Role for the Hypercretin System
Matt Carter, B.Sc and Luis deLecea, PhD
The Locus Coeruleus-Noradrenergic System and Stress: Implications for Post-Traumatic Stress Disorder
Craig Berridge, PhD
Effect Of Stress On Sleep And Its Relationship To Post-Traumatic Stress Disorder
Larry D. Sanford, PhD and Xiangdong Tang, PhD
Stress hormones in post-traumatic stress disorder
Stress Hormones And Post-Traumatic Stress Disorder
Rachel Yehuda, PhD
Low Basal Cortisol And Startle Responding As Possible Biomarkers Of Post-Traumatic Stress Disorder: The Influence Of Internalizing And Externalizing Comorbidity
Mark W. Miller, PhD, Erika J. Wolf, MA, Laura Fabricant, BA, and Nathan Stein, PhD
Brain Imaging in Post-Traumatic Stress Disorder
Functional Neuroimaging In Post-Traumatic Stress Disorder
Israel Liberzon, MD and Sarah N. Garfinkel, PhD
The Amygdala in Posttraumatic Stress Disorder
Lisa Shin, PhD
Treatment Strategies
Pharmacological Treatment Of Post-Traumatic Stress Disorder
Murray Raskind, MD
Guided Imagery as a Therapeutic Tool in Post-traumatic Stress Disorder
Jennifer Strauss, PhD, Patrick S. Calhoun, PhD and Christine E. Marx, MD, MA
18. Virtual Reality Exposure Therapy for Combat Related Post-Traumatic Stress Disorder
Albert Rizzo, PhD, Greg Reger, PhD, Greg Gahm, PhD, JoAnn Difede, PhD and Barbara O. Rothbaum, PhD, ABPP