Table of Contents Contemporary Endocrinology Energy Metabolism and Obesity: Research and Clinical Applications Editor: Patricia A. Donohoue, MD Professor of Pediatrics, Division of Endocrinology and Diabetes University of Iowa Carver College of Medicine Children’s Hospital of Iowa at University of Iowa Hospitals and Clinics 200 Hawkins Drive, 2858 JPP Iowa City, IA 52242-1083 Phone 319-356-3164 FAX 319-356-8170 Chapter 1: Molecular Physiology of Monogenic and Syndromic Obesities in Humans Wendy K. Chung and Rudolph L. Leibel Chapter 2 : Leptin Signaling In the Brain Ofer Reizes, Stephen C. Benoit, and Deborah J. Clegg Chapter 3: Inactivating Melanocortin-4 Receptor Mutations and Human Obesity Ya-Xiong Tao Chapter 4: The Role of Central Melanocortins in Cachexia Daniel L. Marks Chapter 5: The Efferent Arm of the Energy Balance Regulatory Pathway: Neuroendocrinology and Pathology Robert H. Lustig Chapter 6: Adiponectin: A Multifunctional Adipokine Kristen Clarke and Robert L. Judd Chapter 7: The Role of the Gastrointestinal Hormones Ghrelin, Peptide YY and Glucagon-like Peptide-1 in the Regulation of Energy Balance Ruben Nogueiras, Hilary Wilson, Diego Perez-Tilve and Matthias H. Tschöp Chapter 8: The Role of GHSs/Ghrelin in Feeding and Body Composition Cyril Y. Bowers, Blandine Laferrere, David Hurley, and Johannes D. Veldhuis Chapter 9: Interaction Between Physical Activity and Genetic Factors in Complex Metabolic Disease Paul W. Franks and Stephen M. Roth Chapter 10: 11ß-Hydroxysteroid Dehydrogenase Type 1 and Obesity Roland H. Stimson and Brian R. Walker Chapter 11:Prader-Willi Syndrome (PWS): A Model of Disordered Energy Homeostasis Andrea Haqq Chapter 12: Antipsychotic Medication-Induced Weight Gain and Risk for Diabetes and Cardiovascular Disease John W. Newcomer Chapter 13: Treatment of Insulin Resistance in Youth: The Role of Metformin Molly Emott and Michael Freemark Chapter 14: The Surgical Approach to Morbid Obesity Edward E. Mason, Mohammad K. Jamal and Thomas O’Dorisio