Signal Transduction and the Gasotransmitters

Part I. Gasotransmitters: Past, Present, and Future

The Evolution of Gasotransmitter Biology and Medicine: From Atmospheric Toxic Gases to Endogenous Gaseous Signaling Molecules
Rui Wang

Interactions Between Gasotransmitters
Ray J. Carson, Gunter Seyffarth, Rubina Mian, and Helen Maddock

Part II. The Emergence of the First Gasotransmitter: Nitric Oxide

Nitric Oxide: Synthesis and Metabolism, Tissue Stores, and the Relationship of Endothelium-Derived Nitric Oxide to Endothelium-Dependent Hyperpolarization
Chris R. Triggle, Hong Ding, Ella S. M. Ng, and Anthie Ellis

Chemical Interaction of Nitric Oxide With Protein Thiols: S-Nitrosylation Signaling
Allan Doctor and Benjamin M. Gaston

Nitric Oxide and Adenosine Triphosphate-Sensitive Potassium Channels: Their Different Properties But Analogous Effects on Cellular Protection
Shoji Sanada, Jiyoong Kim, and Masafumi Kitakaze

Interactions of Nitric Oxide and Related Radical Species With KCa Channels
Yanping Liu and David D. Gutterman

Nitric Oxide and Voltage-Gated Ca2+ Channels
Claudio Grassi, Marcello D'Ascenzo, and Gian Battista Azzena

Interactions of Nitric Oxide and Cardiac Ion Channels
Zhao Zhang, Kathryn A. Glatter, and Nipavan Chiamvimonvat

S-Nitrosylation of Cyclic Nucleotide-Gated Channels
Marie-Christine Broillet

Part III. Story of a Silent Killer: The Resurgence of Carbon Monoxide as the Second Gasotransmitter

Synthesis and Metabolism of Carbon Monoxide
Stefan W. Ryter and Augustine M. K. Choi

Interaction of Carbon Monoxide With K+ Channels in Vascular Smooth Muscle Cells
Rui Wang

Modulation of Multiple Types of Ion Channels by Carbon Monoxide in Nonvascular Tissues and Cells
Rui Wang

The Molecular Mechanisms Underlying the Effects of Carbon Monoxide on Calcium-Activated K+ Channels
Lingyun Wu

Carbon Monoxide and Signal Transduction Pathways
Patty J. Lee and Leo E. Otterbein

Carbon Monoxide-Induced Alterations in the Expression of KCa Channels in Pulmonary Artery Smooth Muscle Cells
Eric Dubuis, Prem Kumar, Pierre Bonnet, and Christophe Vandier

Part IV. Gas of the Rotten Egg: Hydrogen Sulfide as Another Gasotransmitter

Hydrogen Sulfide Production and Metabolism in Mammalian Tissues
Kenneth N. Maclean and Jan P. Kraus

Toxicological and Environmental Impacts of Hydrogen Sulfide
Sheldon H. Roth

Hydrogen Sulfide and the Regulation of Neuronal Activities
Hideo Kimura

The Role of Hydrogen Sulfide as an Endogenous Vasorelaxant Factor
Rui Wang, Youqin Cheng, and Lingyun Wu

Hydrogen Sulfide and Visceral Smooth Muscle Contractility
Philip K. Moore

Interaction of Hydrogen Sulfide and Adenosine Triphosphate-Sensitive Potassium Channels in Vascular Smooth Muscle Cells
Rui Wang

Part V. Gasotransmitters, Other Gaseous Molecules, and Cell Metabolism

Gasotransmitters as a Novel Class of Metabolic Regulators: Nitric Oxide, Carbon Monoxide, and Nitrous Oxide
Misato Kashiba

Index