Atypical Parkinsonian Disorders
Clinical and Research Aspects
Samenvatting
A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.
Specificaties
Inhoudsopgave
Irene Litvan
Historical Issues and Atypical Parkinsonian Disorders
Christopher G. Goetz
Epidemiology of Progressive Supranuclear Palsy and Multiple System Atrophy
Adam Zermansky and Yoav Ben-Shlomo
Neuropathology of Atypical Parkinsonian Disorders
Ian R. A. Mackenzie
Animal Models of Tauopathies
Jada Lewis and Michael Hutton
Neurodegenerative a-Synucleinopathies
Michel Goedert and Maria Grazia Spillantini
Computer Modeling in Basal Ganglia Disorders
José Luis Contreras-Vidal
Atypical Parkinsonian Disorders: Neuropathology and Nosology
Charles Duyckaerts
Genetics of Atypical Parkinsonism: Implications for Nosology
Thomas Gasser
Medical History and Physical Examination in Parkinsonian Syndromes: How to Examine a Parkinsonian Syndrome
Marie Vidailhet, Frédéric Bourdain, and Jean-Marc Trocello
Role of Neuropsychiatric Assessment in Diagnosis and Research
Dag Aarsland, Uwe Ehrt, and Clive Ballard
Added Value of the Neuropsychological Evaluation for Diagnosis and Research of Atypical Parkinsonian Disorders
Bruno Dubois and Bernard Pillon
Role of Praxis in Diagnosis and Assessment
Ramón Leiguarda
Role of Visuospatial Cognition Assessment in the Diagnosis and Research of Atypical Parkinsonian Disorders
Paolo Nichelli and Anna Magherini
Role of Ocular Motor Assessment in Diagnosis and Research
R. John Leigh and David S. Zee
Characterizing and Assessing Speech and Language Disturbances
Carol Frattali and Joseph R. Duffy
Quality of Life Assessment in Atypical Parkinsonian Disorders
Anette Schrag and Caroline E. Selai
Progressive Supranuclear Palsy
Irene Litvan
Corticobasal Degeneration: The Syndrome and the Disease
Bradley F. Boeve
Multiple System Atrophy
Felix Geser and Gregor K. Wenning
Clinical Diagnosis of Dementia With Lewy Bodies
David J. Burn, Urs P. Mosimann, and Ian G. McKeith
Clinical Diagnosis of Familial Atypical Parkinsonian Disorders
Yoshio Tsuboi, Virgilio H. Evidente, and Zbigniew K. Wszolek
Clinical Diagnosis of Vascular Parkinsonism and Nondegenerative Atypical Parkinsonian Disorders
Madhavi Thomas and Joseph Jankovic
Role of Electrophysiology in Diagnosis and Research in Atypical Parkinsonian Disorders
Josep Valls-Solé
Role of CT and MRI in Diagnosis and Research
Mario Savoiardo and Marina Grisoli
Role of Functional Magnetic Neuroimaging in Diagnosis and Research
Hartwig Roman Siebner and Günther Deuschl
PET and SPECT Imaging in Atypical Parkinsonian Disorders
Alexander Gerhard and David J. Brooks
Current and Future Therapeutic Approaches
Elmyra V. Encarnacion and Thomas N. Chase
Rehabilitation of Patients With Atypical Parkinsonian Disorders
Daniel K. White, Douglas I. Katz, Terry Ellis, Laura Buyan-Dent, and Marie H. Saint-Hilaire
Overview and Future Research
Andrew Lees
Index