Lawrence H. Lash
Humana Press
2005e druk, 2004
9781588293244
Drug Metabolism and Transport
Molecular Methods and Mechanisms
Specificaties
Gebonden, 388 blz.
|
Engels
Humana Press |
2005e druk, 2004
ISBN13: 9781588293244
Rubricering
Onderdeel van serie
Methods in Pharmacology and Toxicology
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
Specificaties
ISBN13:9781588293244
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:388
Uitgever:Humana Press
Druk:2005
Inhoudsopgave
Renal Cytochrome P450s and Flavin-Containing Monooxygenases.- Experimental Approaches for the Study of Cytochrome P450 Gene Regulation.- Insulin and Growth Factor Signaling.- Catalytic Function and Expression of Glutathione Transferase Zeta.- Glucuronidation of Fatty Acids and Prostaglandins by Human UDP-Glucuronosyltransferases.- Transcriptional Regulation of UDP-Glucuronosyltransferases.- Phenotypic and Genotypic Characterization of N-Acetylation.- Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen.- Modulation of Drug Metabolism and Antiviral Therapies.- Modulation of Thiols and Other Low-Molecular-Weight Cofactors.- Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics.- Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier.- Glutathione Transport in the Kidneys.- Human Cytosolic Sulfotransferases.