Edward J. Massaro,
John M. Rogers
Humana Press
2004e druk, 2004
9781588292155
The Skeleton
Biochemical, Genetic, and Molecular Interactions in Development and Homeostasis
Specificaties
Gebonden, 428 blz.
|
Engels
Humana Press |
2004e druk, 2004
ISBN13: 9781588292155
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology-and how it is modified throughout all the stages of life-offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.
Specificaties
ISBN13:9781588292155
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:428
Uitgever:Humana Press
Druk:2004
Inhoudsopgave
I. Chondrogenesis, Chondrocytes, and Cartilage
Molecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal Chondrogenesis
Rocky S. Tuan
Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling
Lillian Shum, Yuji Hatakeyama, Julius Leyton, and Kazuaki Nonaka
Regulation of Chondrocyte Differentiation
Andreia M. Ionescu, M. Hicham Drissi, and Regis J. O'Keefe
Continuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient Mice
Shu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, and Gerard Karsenty
Molecular Biology and Biosynthesis of Collagens
Johanna Myllyharju
Mechanotransduction Pathways in Cartilage
Qian Chen
II. Control of Skeletal Development
Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development: Impact of the loxP/Cre System in Targeted Mutagenesis of the Mouse HoxD Complex
Marie Kmita, Denis Duboule, and József Zákány
Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling
Renee Hackenmiller, Catherine Degnin, and Jan Christian
FGF4 and Skeletal Morphogenesis
Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi, Rosalie Anderson, and Ken Muneoka
Retinoid Signaling and Skeletal Development
Andrea D. Weston and T. Michael Underhill
Retinoids and Indian Hedgehog Orchestrate Long Bone Development
Maurizio Pacifici, Chiara Gentili, Eleanor Golden, and Eiki Koyama
III. Osteoblastic Cell Differentiation
Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation
John C. Lee and Lee-Chuan C. Yeh
Bone MorphogenicProteins, Osteoblast Differentiation, and Cell Survival During Osteogenesis
Cun-Yu Wang
Osteoclast Differentiation
Sakamuri V. Reddy and G. David Roodman
IV. Bone Induction, Growth, and Remodeling
Soluble Signals and Insoluble Substrata: Novel Molecular Cues Instructing the Induction of Bone
Ugo Ripamonti, Nathaniel L. Ramoshebi, Janet Patton, Thato Matsaba, June Teare, and Louise Renton
Perichondrial and Periosteal Regulation of Endochondral Growth
Dana L. Di Nino and Thomas F. Linsenmayer
Computer Simulations of Cancellous Bone Remodeling
Jacqueline C. van der Linden, Harrie Weinans, and Jan A. N. Verhaar
Effects of Microgravity on Skeletal Remodeling and Bone Cells
Pierre J. Marie
V. Bone Mineralization
Quantitative Analyses of the Development of Different Hard Tissues
Siegfried Arnold, Hans J. Höhling, and Ulrich Plate
Fetal Mineral Homeostasis and Skeletal Mineralization
Christopher S. Kovacs
Control of Osteoblast Function and Bone Extracellular Matrix Mineralization by Vitamin D
Johannes P. T. M. van Leeuwen, Marjolein van Driel, and Hulbert A. P. Pols
VI. Skeletal Dysmorphology
Role of Pax3 and PDGF-a Receptor in Skeletal Morphogenesis and Facial Clefting
Simon J. Conway
Genetics of Achondroplasia and Hypochondroplasia
Giedre Grigelioniene
Effects of Boric Acid on Hox Gene Expression and the Axial Skeleton in the Developing Rat
Michael G. Narotsky, Nathalie Wéry, Bonnie T. Hamby, Deborah S. Best, Nathalie Pacico, Jacques J. Picard, Françoise Gofflot, and Robert J. Kavlock
Toxicant-Induced Lumbar and Cervical Ribs in Rodents
John M. Rogers, R. Woodrow Setzer, and Neil Chernoff
Experimental Skeletal Dysmorphology: Risk Assessment Issues
Rochelle W. Tyl, Melissa C. Marr, and Christina B. Myers
Index
Molecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal Chondrogenesis
Rocky S. Tuan
Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling
Lillian Shum, Yuji Hatakeyama, Julius Leyton, and Kazuaki Nonaka
Regulation of Chondrocyte Differentiation
Andreia M. Ionescu, M. Hicham Drissi, and Regis J. O'Keefe
Continuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient Mice
Shu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, and Gerard Karsenty
Molecular Biology and Biosynthesis of Collagens
Johanna Myllyharju
Mechanotransduction Pathways in Cartilage
Qian Chen
II. Control of Skeletal Development
Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development: Impact of the loxP/Cre System in Targeted Mutagenesis of the Mouse HoxD Complex
Marie Kmita, Denis Duboule, and József Zákány
Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling
Renee Hackenmiller, Catherine Degnin, and Jan Christian
FGF4 and Skeletal Morphogenesis
Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi, Rosalie Anderson, and Ken Muneoka
Retinoid Signaling and Skeletal Development
Andrea D. Weston and T. Michael Underhill
Retinoids and Indian Hedgehog Orchestrate Long Bone Development
Maurizio Pacifici, Chiara Gentili, Eleanor Golden, and Eiki Koyama
III. Osteoblastic Cell Differentiation
Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation
John C. Lee and Lee-Chuan C. Yeh
Bone MorphogenicProteins, Osteoblast Differentiation, and Cell Survival During Osteogenesis
Cun-Yu Wang
Osteoclast Differentiation
Sakamuri V. Reddy and G. David Roodman
IV. Bone Induction, Growth, and Remodeling
Soluble Signals and Insoluble Substrata: Novel Molecular Cues Instructing the Induction of Bone
Ugo Ripamonti, Nathaniel L. Ramoshebi, Janet Patton, Thato Matsaba, June Teare, and Louise Renton
Perichondrial and Periosteal Regulation of Endochondral Growth
Dana L. Di Nino and Thomas F. Linsenmayer
Computer Simulations of Cancellous Bone Remodeling
Jacqueline C. van der Linden, Harrie Weinans, and Jan A. N. Verhaar
Effects of Microgravity on Skeletal Remodeling and Bone Cells
Pierre J. Marie
V. Bone Mineralization
Quantitative Analyses of the Development of Different Hard Tissues
Siegfried Arnold, Hans J. Höhling, and Ulrich Plate
Fetal Mineral Homeostasis and Skeletal Mineralization
Christopher S. Kovacs
Control of Osteoblast Function and Bone Extracellular Matrix Mineralization by Vitamin D
Johannes P. T. M. van Leeuwen, Marjolein van Driel, and Hulbert A. P. Pols
VI. Skeletal Dysmorphology
Role of Pax3 and PDGF-a Receptor in Skeletal Morphogenesis and Facial Clefting
Simon J. Conway
Genetics of Achondroplasia and Hypochondroplasia
Giedre Grigelioniene
Effects of Boric Acid on Hox Gene Expression and the Axial Skeleton in the Developing Rat
Michael G. Narotsky, Nathalie Wéry, Bonnie T. Hamby, Deborah S. Best, Nathalie Pacico, Jacques J. Picard, Françoise Gofflot, and Robert J. Kavlock
Toxicant-Induced Lumbar and Cervical Ribs in Rodents
John M. Rogers, R. Woodrow Setzer, and Neil Chernoff
Experimental Skeletal Dysmorphology: Risk Assessment Issues
Rochelle W. Tyl, Melissa C. Marr, and Christina B. Myers
Index