Arne Schousboe,
Hans Bräuner-Osborne
Humana Press
2004e druk, 2003
9781588291431
Molecular Neuropharmacology
Strategies and Methods
Specificaties
Gebonden, 271 blz.
|
Engels
Humana Press |
2004e druk, 2003
ISBN13: 9781588291431
Rubricering
Levertijd ongeveer 8 werkdagen
Samenvatting
A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.
Specificaties
ISBN13:9781588291431
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:271
Uitgever:Humana Press
Druk:2004
Inhoudsopgave
Part I. Molecular Pharmacology of Glutamate Receptors
Computational Studies of Ligand-Receptor Interactions in Ionotropic Glutamate Receptors
Jeremy R. Greenwood and Tommy Liljefors
Delineation of the Physiological Role of Kainate Receptors by Use of Subtype Selective Ligands
Sari E. Lauri, Vernon R. J. Clarke, and Graham L. Collingridge
Molecular Pharmacology of the Metabotropic Glutamate Receptors
Anders A. Jensen
Part II. Molecular Pharmacology of Gaba Receptors
Functional Characterization of GABAA Receptor Ligands In Vitro: Correlation With In Vivo Activity
Bjarke Ebert, Sally Anne Thompson, Signe Í Stórustovu, and Keith A. Wafford
In Vivo Function of GABAA Receptor Subtypes Unraveled With Mutant Mice
Jean-Marc Fritschy
Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling
Bente Frøland, Anne T. Jørgensen, Tommy Liljefors, Martin Mortensen, and Povl Krogsgaard-Larsen
The GABAB Receptor: From Cloning to Knockout Mice
Bernhard Bettler and Hans Bräuner-Osborne
Part III. Molecular Pharmacology of Transmitter Transporters
Structure and Molecular Characterization of the Substrate-Binding Sites of the Dual-Function Glutamate Transporters
Baruch I. Kanner, Michael P. Kavanaugh, and Lars Borre
Allosteric Modulation of Glutamate Transporters
Robert J. Vandenberg and Renae M. Ryan
Characterization of the Substrate-Binding Site in GABA Transporters
Alan Sarup, Orla Miller Larsson, and Arne Schousboe
Insights From Endogenous and Engineered Zn21 Binding Sites in Monoamine Transporters
Claus Juul Loland and Ulrik Gether
A Structural Context for Studying Neurotransmitter Transporter Function
Naomi R. Goldberg, Thijs Beuming, Harel Weinstein, and Jonathan A. Javitch
Functional Mechanisms of GProtein-Coupled Receptors in a Structural Context
Marta Filizola, Irache Visiers, Lucy Skrabanek, Fabien Campagne, and Harel Weinstein
Index
Computational Studies of Ligand-Receptor Interactions in Ionotropic Glutamate Receptors
Jeremy R. Greenwood and Tommy Liljefors
Delineation of the Physiological Role of Kainate Receptors by Use of Subtype Selective Ligands
Sari E. Lauri, Vernon R. J. Clarke, and Graham L. Collingridge
Molecular Pharmacology of the Metabotropic Glutamate Receptors
Anders A. Jensen
Part II. Molecular Pharmacology of Gaba Receptors
Functional Characterization of GABAA Receptor Ligands In Vitro: Correlation With In Vivo Activity
Bjarke Ebert, Sally Anne Thompson, Signe Í Stórustovu, and Keith A. Wafford
In Vivo Function of GABAA Receptor Subtypes Unraveled With Mutant Mice
Jean-Marc Fritschy
Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling
Bente Frøland, Anne T. Jørgensen, Tommy Liljefors, Martin Mortensen, and Povl Krogsgaard-Larsen
The GABAB Receptor: From Cloning to Knockout Mice
Bernhard Bettler and Hans Bräuner-Osborne
Part III. Molecular Pharmacology of Transmitter Transporters
Structure and Molecular Characterization of the Substrate-Binding Sites of the Dual-Function Glutamate Transporters
Baruch I. Kanner, Michael P. Kavanaugh, and Lars Borre
Allosteric Modulation of Glutamate Transporters
Robert J. Vandenberg and Renae M. Ryan
Characterization of the Substrate-Binding Site in GABA Transporters
Alan Sarup, Orla Miller Larsson, and Arne Schousboe
Insights From Endogenous and Engineered Zn21 Binding Sites in Monoamine Transporters
Claus Juul Loland and Ulrik Gether
A Structural Context for Studying Neurotransmitter Transporter Function
Naomi R. Goldberg, Thijs Beuming, Harel Weinstein, and Jonathan A. Javitch
Functional Mechanisms of GProtein-Coupled Receptors in a Structural Context
Marta Filizola, Irache Visiers, Lucy Skrabanek, Fabien Campagne, and Harel Weinstein
Index