Neurons, Circuitry, and Plasticity in the Spinal Cord and Brainstem
Samenvatting
The brain and the spinal cord, together, compose the central nervous system. Only relatively recently has research shifted focus to consider the integral functions at the individual neuronal and network levels that are mediated by the spinal cord. In this volume, recent work is presented addressing developments in this emerging area. Short reviews examine motor neuron synaptic plasticity, molecular signaling in motor circuits, advances in in vivo and in vitro imaging of spinal cord injury, inhibitory and excitatory locomotor programs, and mapping the circuitry of tactile and sensory functions, including nociception and pain relief. Collectively, these papers provide an overview of some of the most exciting topics in spinal cord research spanning basic cellular mechanisms to translational approaches.
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Specificaties
Inhoudsopgave
<p>Neurotransmitters and synaptic components in the Merkel cell–neurite complex, a gentle–touch receptor 13<br /> Srdjan Maksimovic, Yoshichika Baba and Ellen A. Lumpkin</p>
<p>Principles of interneuron development learned from Renshaw cells and the motoneuron recurrent inhibitory circuit 22 <br /> Francisco J. Alvarez, Ana Benito–Gonzalez and Valerie C. Siembab</p>
<p>Dorsally derived spinal interneurons in locomotor circuits 32 <br /> Anna Vallstedt and Klas Kullander</p>
<p>Neuronal correlates of the dominant role of GABAergic transmission in the developing mouse locomotor circuitry 43 <br /> Lea Ziskind–Conhaim</p>
<p>GluA1 promotes the activity–dependent development of motor circuitry in the developing segmental spinal cord 54<br /> Angela M. Jablonski and Robert G. Kalb</p>
<p>Optical imaging of the spontaneous depolarization wave in the mouse embryo: origins and pharmacological nature 60<br /> Yoko Momose–Sato and Katsushige Sato</p>
<p>Imaging spinal neuron ensembles active during locomotion with genetically encoded calcium indicators 71<br /> Christopher A. Hinckley and Samuel L. Pfaff</p>
<p>Glutamatergic reticulospinal neurons in the mouse: developmental origins, axon projections, and functional connectivity 80 <br /> Marie–Claude Perreault and Joel G. Glover</p>
<p>Pre– and postsynaptic inhibitory control in the spinal cord dorsal horn 90 <br /> Rita Bardoni, Tomonori Takazawa, Chi–Kun Tong, Papiya Choudhury, Gregory Scherrer and Amy B. MacDermott</p>
<p>Activity–dependent development of tactile and nociceptive spinal cord circuits 97<br /> Stephanie C. Koch and Maria Fitzgerald</p>
<p>Force–sensitive afferents recruited during stance encode sensory depression in the contralateral swinging limb during locomotion 103 <br /> Shawn Hochman, Heather Brant Hayes, Iris Speigel and Young–Hui Chang</p>
<p>Motor primitives and synergies in the spinal cord and after injury the current state of play 114 <br /> Simon F. Giszter and Corey B. Hart</p>
<p>A dual spinal cord lesion paradigm to study spinal locomotor plasticity in the cat 127 <br /> Marina Martinez and Serge Rossignol</p>
<p>The effects of endocannabinoid signaling on network activity in developing and motor circuits 135<br /> Peter Wenner</p>
<p>Hypoxia–induced phrenic long–term facilitation: emergent properties 143<br /> Michael J. Devinney, Adrianne G. Huxtable, Nicole L. Nichols and Gordon S. Mitchell</p>
<p>Axon regeneration and exercise–dependent plasticity after spinal cord injury 154<br /> John D. Houle and Marie–Pascale Côté</p>
<p>Accelerating locomotor recovery after incomplete spinal injury 164<br /> Brian K. Hillen, James J. Abbas and Ranu Jung</p>