Hematopoietic Stem Cells 8
Samenvatting
This volume stems from the eighth international symposium and workshop entitled "Hematopoietic Stem Cells VIII" held hosted by the University of Tuebingen, Germany in the fall of 2011. The meeting was designed to bring ∼30 leading scientists together to discuss the state–of–the–art in the field of hematopoietic stem cells. Topics reviewed in this volume include: differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches; hematopoietic stem cell expansion; TIM–3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia; regulatory factors for hematopoietic stem cells; reprogramming factors; immune reconstitution and strategies for rebuilding of the immune system after haploidentical stem cell transplantation; zebrafish xenografts as a tool for in vivo studies on human cancer; enhancing engraftment of cord blood cells; current insights into neutrophil homeostasis; and molecular live cell bioimaging in stem cell research, among others.
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Specificaties
Inhoudsopgave
<p>Basic aspects of stem cell biology</p>
<p>Epigenetic differences between sister chromatids? 1<br /> Peter M. Lansdorp, Ester Falconer, Jiang Tao, Julie Brind Amour, and Ulrike Naumann</p>
<p>Reprogramming cell fates: insights from combinatorial approaches 7<br /> Carlos–Filipe Pereira, Ihor R. Lemischka, and Kateri Moore</p>
<p>Molecular live cell bioimaging in stem cell research 18<br /> Max Endele and Timm Schroeder</p>
<p>The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems 28<br /> Stefan Tümpel and K. Lenhard Rudolph</p>
<p>Hematopoietic stem cell development and molecular regulation</p>
<p>In vivo divisional tracking of hematopoietic stem cells 40<br /> Hitoshi Takizawa and Markus G. Manz</p>
<p>Caudal genes in blood development and leukemia 47<br /> Claudia Lengerke and George Q. Daley</p>
<p>Hematopoietic stem cells are regulated by Cripto, as an intermediary of HIF–1 in the hypoxic bone marrow niche 55<br /> Kenichi Miharada, Göran Karlsson, Matilda Rehn, Emma Rörby, Kavitha Siva, Jörg Cammenga, and Stefan Karlsson</p>
<p>G protein–coupled receptor crosstalk and signaling in hematopoietic stem and progenitor cells 63<br /> Robert Möhle and Adriana C. Drost</p>
<p>Molecular and functional characterization of early human hematopoiesis 68<br /> Elisa Laurenti and John E. Dick</p>
<p>Role of N–cadherin in the regulation of hematopoietic stem cells in the bone marrow niche 72<br /> Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Yoshiko Matsumoto, and Toshio Suda</p>
<p>Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches 78<br /> Paul P.C. Roozen, Martijn H. Brugman, and Frank J.T. Staal</p>
<p>Phenotypic and functional heterogeneity of human bone marrow– and amnion–derived MSC subsets 94<br /> Kavitha Sivasubramaniyan, Daniela Lehnen, Roshanak Ghazanfari, Malgorzata Sobiesiak, Abhishek Harichandan, Elisabeth Mortha, Neli Petkova, Sabrina Grimm, Flavianna Cerabona, Peter de Zwart, Harald Abele, Wilhelm K. Aicher, Christoph Faul, Lothar Kanz, and Hans–Jörg Bühring</p>
<p>Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders 107<br /> Maria Ester Bernardo and Willem E. Fibbe</p>
<p>Stem cells and cancer</p>
<p>TIM–3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia 118<br /> Yoshikane Kikushige and Koichi Akashi</p>
<p>Zebrafish xenografts as a tool for in vivo studies on human cancer 124<br /> Martina Konantz, Tugce B. Balci, Udo F. Hartwig, Graham Dellaire, Maya C. André, Jason N. Berman, and Claudia Lengerke</p>
<p>Translational research</p>
<p>Hematopoietic stem cell expansion: challenges and opportunities 138<br /> Marta A. Walasek, Ronald van Os, and Gerald de Haan</p>
<p>Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function 151</p>
<p>Hal E. Broxmeyer</p>
<p>Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation 161<br /> Lena Oevermann, Peter Lang, Tobias Feuchtinger, Michael Schumm, Heiko–Manuel Teltschik, Patrick Schlegel, and Rupert Handgretinger</p>
<p>Current insights into neutrophil homeostasis 171<br /> Stefanie Bugl, Stefan Wirths, Martin R. Müller, Markus P. Radsak, and Hans–Georg Kopp</p>
<p>Prospects and challenges of induced pluripotent stem cells as a source of hematopoietic stem cells 179<br /> Dirk W. van Bekkum and Harald M.M. Mikkers</p>