<p>Ch. 1: Changing demographics of the aging population with heart failure and implications for therapy</p><p> Bodh I. Jugdutt</p><p>Ch. 2: Biology of aging and implications for heart failure therapy and prevention</p><p> Bodh I. Jugdutt</p><p>Ch. 3: Hypertension and prevention of diastolic heart failure in the aging population</p><p> Wilbert S. Aronow</p><p>Maciej Banach</p><p>Ali Ahmed</p><p>Ch. 4: Aging and optimal therapy of systolic heart failure in the elderly</p><p> Nakul Chander Sharma</p><p>Bodh I. Jugdutt</p><p> </p><p>Ch. 5: Atrial fibrillation and heart failure in the aging population</p><p> Pedram Kazemian</p><p>Bodh I. Jugdutt</p><p>Ch. 6: Optimizing therapy of heart failure in the aging population with monitoring in clinics</p><p> John R. Dimitry</p><p>Justin A. Ezekowitz</p><p>Ch. 7: Cardiac alterations in aging, hypertension and diastolic heart failure</p><p> Edith Pituskin</p><p>D. Ian Paterson</p><p>Ch. 8: Polypharmacy and adverse drug reactions in the aging population with heart failure</p><p> Michael W. Rich</p><p>William J. Nienaber</p><p>Ch. 9: Aging-related changes in vascular biology and implications for heart failure therapy in the aging population</p><p> Michael Sean McMurtry</p><p>Ch. 10: Biomarkers and optimal management of heart failure in the aging population</p><p> Hanna K. Gaggin </p><p>James L. Januzzi, Jr.</p><p>Ch. 11: Benefits of Exercise in the elderly</p><p> Ezra A. Amsterdam</p><p>C. Tissa Kappagoda</p><p>Ch. 12: The RAAS in heart failure: an update on clinical trials and opportunities for therapy</p><p> C. Tissa Kappagoda</p><p>Ezra A. Amsterdam</p><p>Ch. 13: Aging and diastolic dysfunction – the interplay of inflammation and extracellular matrix regulation </p><p> Peter Moritz Becher</p><p>Dirk Westermann,</p><p>Carsten Tschöpe</p><p>Ch. 14: Reperfusion and vasodilator therapy in elderly patients with STEMI and heart failure. Improving outcomes</p><p>Bodh I. Jugdutt, </p><p>Anwar Jelani</p><p>Seraj Abualnaja</p><p>Nakul Chander Sharma</p><p>Joseph Szeman Wong</p><p>Ch. 15: Erythropoietin therapy for heart failure</p><p> Margarita Borovka</p><p>Mathew S. Maurer</p><p>Ch. 16: Role of resistin in heart failure in the elderly</p><p> Yasuchika Takeishi</p><p>Ch. 17: Role of coronary artery calcium in cardiovascular risk stratification and management in the aging population</p><p> Craig R. Butler</p><p>Paolo Raggi</p><p>Ch. 18: Aging-and remodeling of the RAS and RAAS and related pathways. Implications for heart failure therapy</p><p>Bodh I. Jugdutt</p><p>Ch. 19: Aging and right ventricular failure from pulmonary hypertension: Effect of right ventricular and pulmonary artery remodeling</p><p>Joseph Szeman Wong</p><p>Bodh I. Jugdutt</p><p>Ch. 20: Biomarkers of cardiovascular aging</p><p> Nirankar S. Neki</p><p>Paramjit S. Tappia</p><p>Naranjan S. Dhalla</p><p>Ch. 21: Changes in the heart that accompany advancing age: Humans to molecules</p><p> Edward G. Lakatta</p><p>Harold A. Spurgeon</p><p>Andzej M. Janczewski</p><p>Ch. 22: Aging-related changes in cell death and cell survival pathways and implications for heart failure therapy</p><p> Guido R.Y. De Meyer</p><p>Dorien M. Schrijvers</p><p>Wim Martinet</p><p>Ch. 23: Aging-related changes in telomeres and telomerases and implications for heart failure therapy</p><p> Pim van der Harst</p><p>Dirk J. van Veldhuisen</p><p>Ch. 24: Aging associated alterations in myocardial inflammation and fibrosis: pathophysiological perspectives and clinical implications</p><p> Arti V. Shinde</p><p>Nikolaos G Frangogiannis</p><p>Ch. 25: Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction </p><p> Nguyen T. Nguyen</p><p>Andriy Yabluchanskiy</p><p>Lisandra E. de Castro Brás</p><p>Yu-Fang Jin</p><p>Merry L. Lindsey</p><p>Ch. 26: Calcium handling defects and changes in cardiac function in the aging heart</p><p> Adriana Adameova</p><p>Nirankar S. Neki</p><p>Paramjit S. Tappia</p><p>Naranjan S. Dhalla</p><p>Ch. 27: Integrins: Implications for aging in heart failure therapy</p><p> Laura L. Daniel</p><p>William L. Joyner</p><p>Mahipal Singh</p><p>Krishna Singh</p><p>Ch. 28: Adipokines as novel biomarkers in aging and heart failure</p><p> Ken Shinmura</p><p>Ch. 29: Aging-related changes in cellular and molecular mechanisms of post-infarction remodeling. Implications for heart failure therapy</p><p> Henry Han-Jen Shih</p><p>Andrew J. Boyle</p><p>Ch. 30: Aging-related changes in mitochondrial function and implication for heart failure therapy</p><p> Satoaki Matoba</p><p>Atsushi Hoshino</p><p>Hiroaki Matsubara</p><p>Ch. 31: Regulation of SERCA via oxidative modifications: Implications for the pathophysiology of diastolic dysfunction in the aging heart</p><p> Fuzhong Qin</p><p>Richard A. Cohen</p><p>Wilson S. Colucci</p><p>Ch. 32: SMP-30 and aging-related cardiac remodeling and heart failure</p><p> Satoshi Suzuki</p>Yasuchika Takeishi