Cesario V. Borlongan,
Ole Isacson,
Paul R. Sanberg
Humana Press
0e druk, 2012
9781468497427
Immunosuppressant Analogs in Neuroprotection
Specificaties
Paperback, 378 blz.
|
Engels
Humana Press |
0e druk, 2012
ISBN13: 9781468497427
Rubricering
Levertijd ongeveer 8 werkdagen
Samenvatting
An authoritative survey of the most recent scientific evidence showing how cyclosporin, FK-506, and their analogs-the neuroimmunophilins-evolved from being purely immunosuppressant "drugs" to neuroprotective "agents". The book focuses on recent preclinical evidence that demonstrates the neurotrophic/neuroprotective effects of immunosuppressants when administered alone or when combined with neural transplantation therapy in animal models of neurological disorders. It also discusses their efficacy and mechanisms of action in vitro and in vivo models of CNS disease, and provides laboratory studies with compelling clinical indications for Alzheimer's disease, Huntington's disease, stroke, traumatic brain injury, spinal cord injury, ALS, sciatic nerve injury, and drug addiction.
Specificaties
ISBN13:9781468497427
Taal:Engels
Bindwijze:paperback
Aantal pagina's:378
Uitgever:Humana Press
Druk:0
Inhoudsopgave
Part I: Immunosuppressants, Neurologic Disorders, and Neuroprotection
Introduction: Immunosuppressants as Neuroprotective Agents
Marcus F. Keep, Hiroyuki Uchino, and Eskil Elmér
Part II: Immunosuppressants and Parkinson's Disease
Cyclosporin-Mediated Amelioration of Degeneration of Dopaminergic Neurons in Experimental Models of Parkinsonism
Norio Ogawa and Ken-ichi Tanaka
Immunophilin Ligands and Dopamine Neurons: Specific Effects in Culture and In Vivo
Lauren C. Costantini and Ole Isacson
Effects of Neuroimmunophilin Ligands on Parkinson's Disease and Cognition
Joseph P. Steiner, Douglas T. Ross, Hansjorg Sauer, Theresa Morrow, and Gregory S. Hamilton
Improved Survival of Grafted Dopamine Neurons by Calcineurin Inhibitors
Roger F. Castilho, Oskar Hansson, and Patrik Brundin
Possible Mechanisms Underlying the Protective Action of Immunosuppressants Against Parkinson's Disease: The Mitochondrial Permeability Transition Pore Hypothesis
L. V. P. Korlipara and A. H. V. Schapira
Part III: Immunosuppressants and Other Age-Related Disorders
Immunosuppressants and Alzheimer's Disease
Mark P. Mattson
Cyclosporin A Protects Striatal Neurons from Mitochondrial Dysfunction: Implications for Huntington's Disease
Liza Leventhal and Jeffrey H. Kordower
Part IV: Immunosuppressants, Stroke, and Traumatic Brain Injury
Cyclosporin A Protects Mitochondria in an In Vitro Model of Hypoxia/Reperfusion Injury
Vladimir Gogvadze and Christoph Richter
Protective Effect of Cyclosporin A on Glial Activation and White Matter Alterations Induced by Chronic Cerebral Hypoperfusion
Hideaki Wakita, Hidekazu Tomimoto, and Ichiro Akiguchi
Blockade of Late-Onset Reduction of Muscarinic Acetylcholine Receptors by Immunosuppressants in Forebrain Ischemia
Ken-ichi Tanaka, M. Asanuma, and NorioOgawa
The Role of Immunophilins in Focal Cerebral Ischemia: Evidence of Neuroprotection by FK506
A. L. McGregor, P. A. Jones, J. F. McCarter, T. E. Allsopp, and J. Sharkey
Immunosuppressants in Traumatic Brain Injury
David O. Okonkwo and John T. Povlishock
Part V: immunosuppressants and Spinal Cord Injury
Inhibition of Lipid Peroxidation by Cyclosporin After Spinal Cord Injury in Rats
Antonio Ibarra and Araceli Diaz-Ruiz
Axonal Regeneration in Cyclosporin A-Treated Rats Submitted to Transverse Section of the Spinal Cord
Guido Palladini and Brunella Caronti
Part VI: Immunosuppressants and Sciatic Nerve Injury
Neuroimmunophilin Ligands Accelerate and Promote Nerve Regeneration in the Rat Peripheral Nerve and Spinal Cord: Role of the Steroid Receptor-FKBP52 Complex
Bruce G. Gold
Neuroimmunophilin Ligands Stimulate Recovery of Injured Sciatic Nerves
Joseph P. Steiner, Heather Valentine, Theresa Morrow, and Gregory Hamilton
Part VII: Immunosuppressants and Other Disorders of the Central Nervous System
Cyclosporin A Prolongs Survival of SOD1 Mutant Mice and Implicates Mitochondrial Permeability Transition in ALS
Marcus F. Keep, Keith S. K. Fong, Katalin Csiszar, and Eskil Elmér
Psychological Effects of Cyclosporine-A
Shigeru Watanabe
Index
Introduction: Immunosuppressants as Neuroprotective Agents
Marcus F. Keep, Hiroyuki Uchino, and Eskil Elmér
Part II: Immunosuppressants and Parkinson's Disease
Cyclosporin-Mediated Amelioration of Degeneration of Dopaminergic Neurons in Experimental Models of Parkinsonism
Norio Ogawa and Ken-ichi Tanaka
Immunophilin Ligands and Dopamine Neurons: Specific Effects in Culture and In Vivo
Lauren C. Costantini and Ole Isacson
Effects of Neuroimmunophilin Ligands on Parkinson's Disease and Cognition
Joseph P. Steiner, Douglas T. Ross, Hansjorg Sauer, Theresa Morrow, and Gregory S. Hamilton
Improved Survival of Grafted Dopamine Neurons by Calcineurin Inhibitors
Roger F. Castilho, Oskar Hansson, and Patrik Brundin
Possible Mechanisms Underlying the Protective Action of Immunosuppressants Against Parkinson's Disease: The Mitochondrial Permeability Transition Pore Hypothesis
L. V. P. Korlipara and A. H. V. Schapira
Part III: Immunosuppressants and Other Age-Related Disorders
Immunosuppressants and Alzheimer's Disease
Mark P. Mattson
Cyclosporin A Protects Striatal Neurons from Mitochondrial Dysfunction: Implications for Huntington's Disease
Liza Leventhal and Jeffrey H. Kordower
Part IV: Immunosuppressants, Stroke, and Traumatic Brain Injury
Cyclosporin A Protects Mitochondria in an In Vitro Model of Hypoxia/Reperfusion Injury
Vladimir Gogvadze and Christoph Richter
Protective Effect of Cyclosporin A on Glial Activation and White Matter Alterations Induced by Chronic Cerebral Hypoperfusion
Hideaki Wakita, Hidekazu Tomimoto, and Ichiro Akiguchi
Blockade of Late-Onset Reduction of Muscarinic Acetylcholine Receptors by Immunosuppressants in Forebrain Ischemia
Ken-ichi Tanaka, M. Asanuma, and NorioOgawa
The Role of Immunophilins in Focal Cerebral Ischemia: Evidence of Neuroprotection by FK506
A. L. McGregor, P. A. Jones, J. F. McCarter, T. E. Allsopp, and J. Sharkey
Immunosuppressants in Traumatic Brain Injury
David O. Okonkwo and John T. Povlishock
Part V: immunosuppressants and Spinal Cord Injury
Inhibition of Lipid Peroxidation by Cyclosporin After Spinal Cord Injury in Rats
Antonio Ibarra and Araceli Diaz-Ruiz
Axonal Regeneration in Cyclosporin A-Treated Rats Submitted to Transverse Section of the Spinal Cord
Guido Palladini and Brunella Caronti
Part VI: Immunosuppressants and Sciatic Nerve Injury
Neuroimmunophilin Ligands Accelerate and Promote Nerve Regeneration in the Rat Peripheral Nerve and Spinal Cord: Role of the Steroid Receptor-FKBP52 Complex
Bruce G. Gold
Neuroimmunophilin Ligands Stimulate Recovery of Injured Sciatic Nerves
Joseph P. Steiner, Heather Valentine, Theresa Morrow, and Gregory Hamilton
Part VII: Immunosuppressants and Other Disorders of the Central Nervous System
Cyclosporin A Prolongs Survival of SOD1 Mutant Mice and Implicates Mitochondrial Permeability Transition in ALS
Marcus F. Keep, Keith S. K. Fong, Katalin Csiszar, and Eskil Elmér
Psychological Effects of Cyclosporine-A
Shigeru Watanabe
Index