The New Angiotherapy
Samenvatting
An international team of experts critically review the recent progress in basic and applied research in angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel targets and the use angiotherapy in the clinic. They also detail the fundamental concepts in the physiology and pathophysiology of angiogenesis and evaluate the potential of angiotherapy in the management of angiogenic disease, highlighting some of the angiogenics and antiangiogenics both in development and in clinical trials.
Specificaties
Inhoudsopgave
Vasculogenesis and Angiogenesis
Robert Auerbach and Wanda Auerbach
Angiogenesis-Regulating Cytokines
Michael S. Pepper, Stefano J. Mandriota, and Roberto Montesano
The Angiopoietins
Pamela F. Jones
Regulation of Vascular Morphogenesis by Extracellular Matrix Proteins
Amy D. Bradshaw and E. Helene Sage
II. Angiogenesis in Health and Disease
Integrin Receptors and the Regulation of Angiogenesis
Dorothy Rodriguez and Peter C. Brooks
Vasoactive Peptides in Angiogenesis
David Andrew Walsh and Tai-Ping D. Fan
Angiogenesis in Wound Healing and Surgery
Wayne A. Morrison, Geraldine M. Mitchell, Jane E. Barker, Tamara Konopka, and Alastair G. Stewart
Angiogenesis and Vascular Endothelial Growth Factor (VEGF) in Reproduction
D. Stephen Charnock-Jones, Yulong He, and Stephen K. Smith
Rheumatoid Arthritis: A Target for Anti-Angiogenic Therapy?
Ewa M. Paleolog and Jadwiga M. Miotla
Diagnostic and Prognostic Significance of Tumor Angiogenesis
Stephen B. Fox and Adrian L. Harris
III. Stimulation of Angiogenesis [Therapeutic Angiogenesis]
Hyaluronan Oligosaccharides Promote Wound Repair: Its Size-Dependent Regulation of Angiogenesis
David C. West and Tai-Ping D. Fan
Role of Thymic Peptides in Wound Healing
Hynda K. Kleinman, Derrick S. Grant, and Katherine M. Malinda
Angiogenesis and Growth Factors in Ulcer Healing
Sandor Szabo, Yuen Shing, M. Judah Folkman, Aron Vincze, Zoltan Gombos, Xiaoming Deng, Tetayana Khomenko, and Masashi Yoshida
Angiogenesis in Skeletal and Cardiac Muscle: Role of Mechanical Factors
Margaret D. Brown and Olga Hudlická
Therapeutic Angiogenesis for the Treatment of Cardiovascular Disease
Jeffrey M. Isner and Takayuki Asahara
Therapeutic Angiogenesis for the Heart
JohannesWaltenberger and Vinzenz Hombach
Contact-Guided Angiogenesis and Tissue Engineering
Robert A. Brown, Giorgio Terenghi, and Clive D. McFarland
IV. Anti-Angiogenesis
Inhibitors of Matrix Metalloproteinases
Peter D. Brown and William G. Stetler-Stevenson
Control of Angiogenesis by Microbial Products
Tsutomu Oikawa
Interaction of Angiogenic Growth Factors with Endothelial Cell Heparan Sulfate Proteoglycans: Implication for the Development of Angiostatic Compounds
Marco Rusnati, Giovanni Tulipano, and Marco Presta
2-Methoxyestradiol: A Novel Endogenous Chemotherapeutic and Anti-Angiogenic Agent
Victor S. Pribluda, Theresa M. LaVallee, and Shawn J. Green
V. Novel Targets
Receptor Tyrosine Kinases in Angiogenesis
Laura K. Shawver, Kenneth E. Lipson, T. Annie T. Fong, Gerald McMahon, and Laurie M. Strawn
Targeting Gene Therapy to the Tumor Vasculature
Kelvin K. W. Lau and Roy Bicknell
Antibody Targeting of Tumor Vasculature
J. Wilson, David C. West and Philip E. Thorpe
Endothelial Monocyte-Activating Polypeptide II: A Novel Injury Signal?
Cliff Murray and Maarten Tas
CD105 Antibody for Targeting of Tumor Vascular Endothelial Cells
Ben K. Seon and Shant Kumar
VI. Angiotherapy in the Clinic
Design of Pharmacological and Diagnostic Strategies for Angiogenesis-Dependent Diseases
Lucia Morbidelli and Marina Ziche
Design of Clinical Trials for Anti-Angiogenics
Elise C. Kohn
Angiogeneis Therapies: Concepts, Clinical Trials, and Considerations for New Drug Development
William W. Li, Vincent W. Li, and Dimitris Tsakayannis
Angiostatin and Endostatin: Recent Advances in Their Biology, Pharmacokinetics, and Potential Clinical Applications
Jesus V. Soriano and B. Kim Lee Sim

