Kynurenine and Serotonin Pathways

Session I. Tryptophan and its Metabolites: Chemical and Analytical Issues.- Retro-, Intro- and Perspectives of Trypto-Fun.- Tryptophan and Related Alkaloids.- Stability of Tryptophan in Peptides Against Oxidation and Irradiation.- Mass Spectrometric Determinations of Tryptophan and its Metabolites.- Signal-to-Noise Optimization of HPLC-Fluorometric Systems and their Application to the Analysis of Indoles.- Brain Indole Metabolism Assessed Using in vivo Dialysis.- Sub-Picogram Determination of Serotonin Using HPLC with Electrochemical Detection for Microdialysis Studies of Serotonin Release.- Session II. Tryptophan Metabolism: Serotonin and Melatonin.- Autoradiographic Measurement of the Rate of Serotonin Synthesis in the Rat Brain.- Autoradiographic Studies of 5HT2 Receptors.- Ambivalence on the Multiplicity of Mammalian Aromatic L-Amino Acid Decarboxylase.- Interrationships of DNA Cycles and Melatonin Synthesis.- Regulation of Melatonin Synthesis in the Ovine Pineal Gland.- Melatonin Synthesis: Multiplicity of Regulation.- Session III. Tryptophan Metabolism: Kynurenines.- The Role of Tryptophan and Kynurenine Transport in the Catabolism of Tryptophan Through Indoleamine 2,3-Dioxygenase.- Kynureninase and Kynurenine 3-Hydroxylase in Mammalian Tissues.- Relationships Between Pteridine Synthesis and Tryptophan Degradation.- Quinolinic acid and Kynurenic acid in the Mammalian Brain.- Kynurenate Forming Enzymes in Liver, Kidney and Brain.- Regulation of Pyridine Nucleotide Coenzyme Metabolism.- Session IV. Biological Effects: Serotonin and Melatonin.- Serotonin: Its Role and Receptors in Enteric Neurotransmission.- Mechanisms of Serotonergic Affect Control.- Neuroendocrine Responses to L-Tryptophan as an Index of Brain Serotonin Function: Effect of Weight Loss.- Melatonin Receptors in the Central Nervous System.- Melatonin Interaction With the Benzodiazepine-GABA Receptor Complex in the CNS.- Session V. Biological Effects: Tryptophan and Kynurenines.- Effects of Tryptophan 2,3-Dioxygenase Inhibitors in the Rat.- Bidirectional Relationships Between Tryptophan and Social Behavior in Vervet Monkeys.- The Regulation of Brain Kynurenic Acid Content: Focus on Indole-3-Pyruvic Acid.- Physiological Role of 3-Hydroxykynurenine and Xanthurenic Acid Upon Crustacean Molting.- Kynurenines in the Regulation of Behavior in Insects.- Effects of Quinolinic and Kynurenic Acids on Central Neurons.- Behavioral Abnormalities in Rats After Single Treatment with Quinolinic Acid During Early Ontogenesis.- Tryptophan Nutrition and Metabolism: An Overview.- Comparison of Tryptophan Metabolism In Vivo and in Isolated Hepatocytes from Vitamin B6 Deficient Mice.- Effects of the Diet and other Metabolic Phenomena on Brain Tryptophan Uptake and Serotonin Synthesis.- Effects of Tryptophan and of 5-Hydroxytryptamine Receptor Subtype Agonists of Feeding.- The Role of Serotonin (5-HT) in Feeding Responses to Amino Acids.- Session VII. Clinical Aspects.- Cardiovascular and Endocrine Properties of L-Tryptophan in Combination With Various Diets.- Acute Effects of Meals on Brain Tryptophan and Serotonin in Humans.- Implications of Interferon-induced Tryptophan Catabolism in Cancer, Autoimmune Diseases and AIDS.- Induction of Indoleamine 2,3-Dioxygenase in Tumor Cells Transplanted into Allogeneic Mouse: Interferon-? is the Inducer.- Short Communications.- Plasma Free 5HT, Plasma 5HIAA and Whole Blood 5HT in the Rat.- Effects of Clomipramine on Extracellular Serotonin in the Rat Frontal Cortex.- Tryptophan Metabolism in Senile Cataract Assessed Patients by High-Performance Liquid Chromatography.- The Effect of Aluminum on Rat Brain and Liver Quinolinic Acid Concentrations.- Kynurenine and Lipid Metabolism.- Content of Tryptophan in Human Hair.- Detection of a New Intermediate Product of Indolealkylamine Metabolism in the Brain.- The Excretion of N1-Methyl-2-pyridone-5-carboxylic Acid and Related Compounds in Human Subjects After Oral Administration of Nicotinic Acid, Trigonalline and N1-Methyl-a-pyridone-5-carboxylic Acid.- Stable Isotope-Labeled Tryptophan as a Precursor for Studying the Disposition of Quinolinic Acid in Rabbits.- Evidence for the Preferential Production of 3-Hydroxyanthranilic Acid from Anthranilic Acid in the Rat Brain.- Chronobiological Effects of L-Tryptophan in Humans: Influence on Melatonin Secretion.- Circadian Patterns of Salivary Melatonin and Urinary 6-Sulfatoxy-melatonin Before and After a 9-hour Time-shift.- Tryptophan Metabolism in Mice Infected with Schistosoma Mansoni.- Inhibition of Tryptophan ? Niacin Metabolism by Dietary Leucine and by Leucine and 2-Oxo-isocaproate in vitro.- Induction of Indoleamine 2,3-Dioxygenase in Human Cells in vitro.- Differential Effects of Estradiol and Hydrocortisone on Liver Tryptophan Pyrrolase in Rats of Various Ages.- Indole-3-Pyruvic Acid as a Direct Precursor of Kynurenic Acid.- Tryptophan Metabolism in Healthy Subjects: Influence of Pyridoxine after Single or Repeated Administrations.- On Kynureninase Activity.- Rat Skin Tryptophan 2,3-Dioxygenase.- Kynurenine 3-Monooxygenase Activity of Rat Brain Mitochondria Determined by High Performance Liquid Chromatography with Electrochemical Detection.- Indolic and Kynurenine Pathway Metabolites of Tryptophan in Rat Brain: Effect of Precursor Availability on in vivo Release.- Kinetic Properties of Human Liver Tryptophan Pyrrolase.- Interferon Type I and II Antagonism: A Novel Regulatory Mechanism of Indoleamine Dioxygenase Induction in Human Peripheral Blood Monocytes and Peritoneal Macrophages.- Quinolinic Acid Concentrations Are Increased in Cerebrospinal Fluid of Rhesus Macaques (Macaca Mulatta) Naturally Infected with Simian Retrovirus Type.- Increased L-Tryptophan, 5-Hydroxyindoleacetic Acid, 3-Hydroxykynurenine and Quinolinic Acid Concentrations in Cerebral Cortex Following Systemic Endotoxin Administration.- Non-Competitive Inhibition of 3-Hydroxyanthranilate-3,4-dioxygenase by 4-Chloro-3-hydroxyanthranilic Acid in Whole Brain of Rat.- Kynurenine-Pyruvate Aminotransferase in Rat Kidney and Brain.- Enzymatic Synthesis of Papiliochrome II.- 4-Halo-3-Hydroxyanthranilates are Potent Inhibitors of 3-Hydroxyanthranilate Oxygenase in the Rat Brain in vitro and in vivo.- On the Disposition of de novo Synthesized Quinolinic Acid in Rat Brain Tissue.- Brain-specific Control of Kynurenic Acid Production by Depolarizing Agents.- Effects of 5-Hydroxytryptophan on Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects.- The Involvement of Bulbospinal Serotonergic Neurons in the Effect of 5-Hydroxytryptophan on Alpha and Gamma Motoneurons.- Quinolinic Acid-Induced Decreases in Acetylcholine Release in the Rat Nucleus Basalis Magnocellularis.- The Role of Transaminations in Pharmacological Effects of Indole-3-Pyruvic Acid.- Endocrine Response of Prolactin, Cortisol, and Growth Hormone to Low Dose Intravenous L-Tryptophan in Healthy Subjects During Day and Night.- Specific Binding of L-Tryptophan to Serum Albumin and its Function in vivo.- Effects of L-Tryptophan on the Brainstem Indole and Catecholamine Metabolites in Spontaneously Hypertensive Rats.- Effects of Tryptophan on the Development of Deoxycorticosterone Acetate (DOCA)-induced Hypertension in Rats.- Cytotoxicity of 3-Hydroxykynurenine: Implications for CNS Damage in Neonatal Vitamin B-6 Deficiency.- Pellagra, Mycotoxins, and Tryptophan-niacin Metabolism.- Levels of Non-Proteic Tryptophan in Milk and Soybean Formulas.- Characterization of L-Tryptophan Transport into Liver in Suckling Rats.- Efficiency of Exogenous Quinolinic Acid, a Metabolite of Tryptophan, as a Niacin Precursor in Rats.- Why Does a Difference in Growth Rate Between Rats of the Wistar and Sprague Dawley Strains Occur When a Niacin-free and Tryptophan-limiting Diet is Fed?.- Plasma Free 5HT and Platelet 5HT in Depression: Case-control Studies and the Effect of Antidepressant Therapy.- Kynurenine and Mesangial-Proliferative Glomerulonephritis.- Impairment of Kynurenine Metabolism in Cardiovascular Disease.- Tryptophan and its Metabolites in a Family with Hartnup Disease.- Effect of Huntington’s and Alzheimer’s Diseases on the Transport of Nicotinic Acid or Nicotinamide Across the Human Blood-Brain Barrier.- Effects of Profound Insulin-induced Hypoglycemia on Quinolinic Acid in Hippocampus and Plasma.- Brain and Cerebrospinal Fluid Quinolinic Acid Concentrations in Patients with Intractable Complex Partial Seizures.- Cerebrospinal Fluid Quinolinic Acid Concentrations are Increased in Acquired Immune Deficiency Syndrome.- Production of Quinolinic Acid and Kynurenic Acid by Human Glioma.- Contributors.