Protein Design and the Development of New Therapeutics and Vaccines

I. Advances in the Structural Analysis of Proteins.- 1 Dynamic Processes in Proteins by X-Ray Diffraction.- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins.- II. Protein Folding and Stability.- 3 Protein Folding and Stability.- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo.- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation.- III. Principles of Receptor Design and Regulation.- 6 Protein—Tyrosine Kinases and Their Substrates: Old Friends and New Faces.- IV. The Guanine Nucleotide Binding Protein Family.- 7 G Proteins: A Family of Signal-Transducing Molecules.- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and ?? Dimers in Regulation of Ionic Channels and Adenylyl Cyclase.- 9 Structural Homologies in G-Binding Proteins.- V. Modeling and Structure Prediction in Macromolecules.- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules.- 11 Computer Simulation Methods as Applied to Site-Specific Mutations.- 12 Dihydrofolate Reductase: A Paradigm for Drug Design.- VI. Protein Engineering and Enzyme Design.- 13 Chemical Approaches to Protein Engineering.- 14 New Engineered Proteins for Use in Therapy and Vaccine Design.- 15 Receptor-Based Design of Dihydrofolate Reductase Inhibitors.- VII. Macromolecules and Targeted Drug Delivery.- 16 Control of the Biological Dispersion of Therapeutic Proteins.- 17 Antibody-Mediated Drug Delivery.- 18 Semisynthetic Catalytic Antibodies.- VIII. Strategies for Directed Mutagenesis of Proteins.- 19 Engineering Novel, Prolonged-Acting Insulins.- IX. Design of Novel Antiviral Agents and Vaccines.- 20 Studies on the Structure andFunction of Ubiquitin.- 21 Recognition at Membrane Surfaces: Influenza HA and Human HLA.