Recent Advances in Mucosal Immunology

Introductory Address.- Perturbations in Peyer’s Patch B Cell Populations Indicative of Priming for a Secretory IgA Response.- Session I: Regulation of Differentiation of Mucosal Lymphocytes.- Rabbit IgA Heavy Chain Genes: Cloning and in vitro Expression.- Immunoglobulin Gene Expression in Wasted Mice.- Molecular Aspects of T Cell Regulation of B Cell Isotype Differentiation.- Switch T Cell Line, ST, Induces an Ig Class Switch in Surface Isotype.- Regulatory T Cell Networks in the Secretory Immune System.- Novel Regulatory Mechanisms of IgA Synthesis: Respective Roles of Neuropeptides and Cells of the Anti-Suppressor Circuit.- Fc-Specific Suppressor T Cells.- Isotype-Specific Immunoglobulin Binding Factors of IgA and IgE.- Isotype Specific Immunoregulation: Role of Fc?R+ T Cells and IBF? in IgA Responses.- Autoreactive T Cells Regulating B Cell Growth and Differentiation in Murine Peyer’s Patches.- T Cell Clones That Help IgA Responses.- Antigen-Specific Helper T Cells in the Intestine: Origin and Migration.- Limiting Dilution Analysis of Functional T Cells in the Gut Mucosa.- Isotype-Specific Immunoregulation: T Contrasuppressor Cells Protect IgA Responses in Oral Tolerance.- Regulatory T Cells in the Galt.- T Dependent Induction of an IgA and IgM Anti-Polysaccharide Response.- A Predominant Idiotype in the Gut-Associated Lymphoid Tissue.- Isolation of Peyer’s Patch T Cell Subsets Involved in Isotype Specific Immunoregulation.- Expression of Substance P and Somatostatin Receptors on a T Helper Cell Line.- N-Terminal Ten Amino Acid Sequence Determined for B-Cell Differentiation Factor Derived from Rabbit Breast Milk Cell Supernatant.- A Novel Pre-B Cell Precursor: Phenotypic Characterization and Differentiation Induction by Dendritic Cell-T Cell Mixtures.- The Role of Epithelial Cells as Accessory Cells.- Antigen Presentation by Gut Epithelial Cells: Secretion by Rat Enterocytes of a Factor with IL-1-Like Activity.- Syngeneic and Allogeneic T Cell Reactivity to I-Region Determinants on Rat Intestinal Epithelial Cells.- Differential Tissue Distribution of HLA-DR, -DP and -DQ Antigens.- Mucosal T Lymphocytes in Human Colonic Schistosomiasis: Relationship to MHC Antigens.- Session II: Mucosa Associated Lymphoreticular Tissue and Lymphocyte Homing.- Canine Peyer’s Patches: Macroscopic, Light Microscopic, Scanning Electron Microscopic and Immunohistochemical Investigations.- The Role of Peyer’s Patches in Intestinal Humoral Immune Responses is Limited to Memory Formation.- Murine Peyer’s Patches are Capable of Generating a Cytotoxic T Cell (CTL) Response to Nominal Antigens.- Immunocytochemical Studies of the Vascular Endothelial Cells in Human Peyer’s Patches and Solitary Lymphoid Follicles.- Migration of Peyer’s Patch IgA Precursor Cells.- Migration of Individual Lymphocytes into Peyer’s Patches in vivo.- Chemotaxis as a Mechanism for Recruitment of Mucosal Plasma Cell Precursors.- Properties of Human B Cells Terminating in Normal Gut-Associated Lymphoid Tissue, Including Peyer’s Patches.- Session III: Immunology of Mucosa-Associated Tissues and Glands.- Subclass Distribution OF IgG- and IgA-Producing Cells in Secretory Tissues and Alterations Related to Gut Diseases.- Altered Patterns of Secretion of IgA and IgG Subclasses by Ulcerative Colitis and Crohn’s Disease Intestinal Mononuclear Cells.- Immunohistochemical Analysis of Human Inflammatory Appendix.- Characterization and Mitogenic Responsiveness of Murine Mammary Gland Mononuclear Cells.- Clearance, Localization and Catabolism of Intravenously Administered Protein Antigens in Lactating Mice.- Specific Antibacterial Antibody-Producing Cells in Human Nasal Mucosa.- Incidence and Distribution of Immunocytes in the Murine Oral Mucosa.- Characterization of Lymphoid Cells from the Human Fallopian Tube Mucosa.- Ultrastructural Localization of IgA and IgG in Uterine Epithelial Cells Following Estradiol Administration.- Origin of IgA and IgG Antibodies in the Female Reproductive Tract: Regulation of the Genital Response by Estradiol.- Cholecystokinin-Induced Release of IgA Antibodies in Rat Intestine.- A Model for Paneth Cell Study: Tissue Culture of the Hyperplastic Paneth Cell Population of Rabbit Thiry-Vella Ileal Loops.- Antigen Induced Gastrin Release: An Immunologic Mechanism of Gastric Antral Mucosa.- Immunocytochemical Markers for Human Milk Macrophages and Epithelial Cells.- Pleomorphic Adenomas Contain a Keratin-Negative Population of HLA-DR-Positive Dendritic Cells.- Discordance between IgA B Cell Precursors and the Secretion of IgA Antibody to Bacterial Polysaccharides.- Session IV: Effector Functions in Mucosal Immunity.- Cytotoxic Lymphocytes in Human Intestinal Mucosa.- T Cell and Mononuclear Phagocyte Populations of the Human Small and Large Intestine.- Functional and Phenotypic Analysis of Lymphocytes Isolated from Human Intestinal Mucosa.- Monoclonal Antibodies Specific for Human and Rat Intestinal Lymphocytes.- Isolation and Characterization of Rabbit Ileal Lamina Propria Mononuclear Cells.- Rabbit Ileal Lamina Propria (LP) Lymphocytes Give Poor Blastogenic Responses to KLH Immunization and Concanavalin A Mitogenesis.- T Cell-Driven Appearance of Mononuclear Cells, Mast Cells and Goblet Cells in the Respiratory Tract.- Antibacterial Activity of Lymphocytes Armed with IgA.- Antibacterial Activity against Streptococcus Pneumoniae by Mouse Lung Lymphocytes.- Potentiation of Rat Colon Intraepithelial Lymphocyte (IEL) Natural Killer (NK) Activity with Indomethacin.- Natural Killer (NK) Cell Activity against Enteric Murine Coronavirus Mediated by Intestinal Leukocytes.- Inhibition of Natural Killer (NK) Activity by Human Colostral and Serum IgA.- HSV-1 Infected Oral Epithelial Cells are Targets for Natural Killer Cells.- Involvement of Human Immunodeficiency Virus (HIV) in Gingiva of Patients with AIDS.- RFc Alpha-Bearing Cells and IgA-Mediated Phagocytosis in the Mouse Oral Mucosa.- In vitro Effects of IgA on Human Polymorphonuclear Leukocytes.- Presence of Fc Receptors for IgA on Rat Alveolar Macrophages but Not Peritoneal Macrophages.- Enumeration, Receptor Expression and Phagocytic Capabilities of Eosinophils of Human Colon Mucosa.- Cofactor Requirements for Expression of Lactoferrin Bactericidal Activity on Enteric Bacteria.- Interaction of Antisera to the Secretory Component with Fc?R.- Mast Cell Pleomorphism: Properties of Intestinal Mast Cells.- Intestinal Mucosal Mast Cells in Rats with Graft-Versus-Host Reaction.- Attempts to Enhance RNA Synthesis and Isolate mRNA from Mast Cells.- Mucosal Mast Cells and the Intestinal Epithelium.- Induction of Proliferative and Destructive Graft-Versus-Host Reactions in the Small Intestine.- Gut Injury in Mouse Graft-Versus-Host Reaction (GVHR).- Session V: Effects of Environmental Antigens on the Immune Response.- Development of Intestinal Mucosal Barrier Function to Antigens and Bacterial Toxins.- Role of LPS Responsiveness in Urinary Tract Infection.- A Model for Lipopolysaccharide-Membrane Interaction.- Pulmonary Cellular Reactions to Schistosoma Mansoni Schistosomula in Normal and Vaccinated Mice.- The Role of Antigen Processing and Suppressor T Cells in Immune Responses to Dietary Proteins in Mice.- Oral Tolerance Induced by Gut-Processed Antigen.- Delayed Recovery of Orally Induced Tolerance to Proteins in Irradiated and Spleen-Cell Reconstituted Mice.- Mucosal Immunity and Tolerance in Neonatal Rabbits.- Abnormalities of Oral Tolerance in NZB/W Female Mice: Relationship of Antibodies to Dietary Antigens in Human Systemic Lupus Erythematosus.- Effect of Substance P on Human Lymphocyte Proliferation in vitro: A Comparison between Normal and Birch Pollen Allergic Individuals.- Endocrine Regulation of the Ocular Secretory Immune System.- The Effects of Moderate Protein Deficiency or High Vitamin E on Intestinal Secretory and Serum IgA Levels in Mice.- Immunological and Immunopathological Characterization of a Mucosal Antigen from Guinea Pig Small Intestine.- Transient Dietary Hypersensitivity in Mice and Pigs.- Passage of Dietary Antigens in Man: Kinetics of Appearance in Serum and Characterization of Free and Antibody-Bound Antigen.- Detection of Food Antigen-Specific IgA Immune Complexes in Human Sera.- Flow Cytometry: A New Approach to the Isolation and Characterization of Kupffer Cells.- Barrier Defense Function of the Small Intestine: Effect of Ethanol and Acute Burn Trauma.- Intestinal Absorption of Bacterial Cell Wall Polymers in Rats.- Size Distribution of Serum IgA Antibodies to Food Proteins: Bovine Beta-Lactoglobulin (BLG), Bovine Serum Albumin (BSA) and Gliadin (GL).- Impairment of IgA Expression and Cell Mediated Immunity Observed in Peyer’s Patches of Protein-Depleted Rats at Weaning and then Fed on 20% Casein.- Isolation and Enumeration of Isotype Specific Plaque Forming Cells from the Murine Intestine to Study the Development of the Intestinal B Cell Background Response.- Serum IgG and IgE Antibody against Aerosolised Antigens from Nephrops Norvegicus among Seafood Process Workers.- The Effect of Exercise on Secretory and Natural Immunity.- Author Index.