Section I Neuroanatomy of Serotonergic and Related Systems.- Localization of Serotonin-Like Immunoreactivity in the Central Nervous System and Pituitary of the Rat, with Special References to the Innervation of the Hypothalamus.- Serotonin Binding Protein: Role in Transmitter Storage in Central and Peripheral Serotoneroic Neurons.- Radioautographic Investigation of Serotonin Cells.- Anatomical Evidence for GABA-5 HT Interaction in Serotonergic Neurons.- Evidence for the Coexistence of Serotonin and Substance P in Single Raphe Cells and Fiber Plexuses: Combined Immunocytochemistry and Autoradiography.- Section II Role of Serotonin in Processing of Nociceptive Information.- Effects of Peripherally and Centrally Administered Serotonin on Primate Spinothalamic Neurons.- The Role of Serotonin in Modulation of Nociceptive-Reflexes.- Role of the Raphe Nuclei in Stimulation Producing Analgesia.- Descending Control of Pain Transmission: Possible Serotonergic-Enkephalinerginc Interactions.- Section III The Regulation of Synthesis.- Synthesis and Quantitative Aspects of Dihydrobiopterin Control of Cerebral Serotonin Levels.- Influence of Plasma Trytophan on Brain 5-HT Synthesis and Serotonergic Activity.- Tryptophan Availability and the Control of 5-Hydroxytryptamine and Tryptamine Synthesis in Human CNS.- Regulatory Properties of Neuronal Tryptophan Hydroxylase.- Studies of the Oxygen Sensitivity of Tryptophan Hydroxylase.- Influence of Histamine on Serotonin Metabolism in Rat Brain.- Serotonin and Dopamine Synthesis in Phenylketonuria.- Section IV Serotonin Receptors.- Effect of Serotonin and Melatonin on the Electrophysiological Behaviour of the Plasma Membrane.- Identification of Serotonin-Binding Proteins Using a Photoaffinity Labeling Probe.- Serotonin-Receptors Coupled with an Adenylate Cyclase in the Rat Brain: Non-Identity with 3H-5-HT Binding Sites.- Brain Serotonin Receptors and Neuropsychiatrie Disorders.- Structure-Activity Relationships in the Actions of 1-Phenyl-Piperazines on Brain Serotonin Receptors.- Section V Regulation and Integration of Serotonergic Systems.- The Action of Serotonin in the Rat Hippocampus.- Uptake and Metabolism of Serotonin and Amino Acids in Thiamine Deficiency.- The Serotonin Connection: Some Evidence for a Specific Metabolic Organization.- Role of Serotonin in the Hypothalamic Regulation of Pituitary Function.- Evidence for Neuronal Feedback Regulation of Serotonin Formation in Brain.- Section VI Developmental Aspects of Serotonergic Systems.- Neurohumor Substances as Neural Growth Factors.- Roles for Serotonin in Neuroembryogenesis.- Developmental-Regulatory Aspects of Brain Tryptophan Hydroxylase.- Serotonin in Development of Cyclic Reproductive Function.- Section VII Serotonin and Behavior-Animal Models.- The Interaction of Indole Derivatives with the Serotonin Receptor and Non-Dopaminergic Cicrling Behavior.- Some Behavioural Interactions between 5-Hydroxytryptamine and Dopamine.- Serotonergic-Dopaminergic Interactions: Implications for Hyperkinetic Disorders.- Serotonin Metabolism of Animal Model of Depression.- Hypersensitive Serotonergic Receptors: A New Hypothesis for one Subgroup of Unipolar Depression Derived from an Animal Model.- An Animal Behavior Model for Decreased Central Serotonergic Function.- Studies on the Role of Central 5-HT Neurons in Avoidance Learning: A Behavioral and Biochemical Analysis.- Section VIII Serotonin and Behavior Psychiatry.- On the Clinical Significance of Serotonin and 5-HIAA in Body Fluids.- Serotonin Metabolite Concentrations in Cerebrospinal Fluid from Schizophrenic Patients — Relationships to Family History.- Tryptophan in the Treatment of Depression.- Studies of CSF 5-HIAA in Depression and Suicidal Behaviour.- Serotonin and Dopamine Disturbances in Patients with Unipolar Depression and Parkinsonism.- Abstracts.- ccelerated Turn-Over of Spinal 5-HT by Electrical Stimulation of the Posterior Raphe Nuclei in the Rat.- Actions of Benzodiazepine Drugs on Cerebral 5-Hydroxytryptamine Mechanism in the Mouse.- A Serotoninergic Happening in the Locus Coeruleus: A Radioautographic and Biochemical Demonstration.- Central Interactions of Kynurenine with Serotonin: Direct or Indirect?.- ?-Chloroamphetamine and ?-Methyltryptamine-Correlation of Behavioural Response with 5TH Release.- Correlations between Rat Brain 5-Hydroxytryptamine Metabolism and the Analgesic Response to Footshock in Non-Drug Treated Rats.- Developmental Changes in the Turnover of Mao A in the Rat Brain.- Differential Radioautography of 3H-5 HTP or 3H-DOPA Concentrating Cells in the Brain Stem of Insomniac Cats.- Evaluation of Central Serotonergic and Antiserotonergic Activities.- Hyperactivity in Rats Treated with Monoamine Oxidase Inhibitors and the Specific 5-HT Reuptake Blocker LM-5008.- Interactions between Serotonergic and Dopaminergic Systems in Rat Brain Demonstrated by Small Unilateral Lesions of the Raphe Nuclei.- In Vivo Uptake and Retrograde Axonal Flow of 3H-5 HT by Central Serotoninergic Systems.- Involvement of 5-Hydroxytryptamine in Caudate Dopamine Release Following Tail-Pinch: Studies with Linear Sweep Voltammetry in Vivo.- Latency of Sleep Inducing Effects of 5HTP in PCPA Pretreated Cats.- Possible Dopaminergic Control of newly Synthetized 3H-Serotonin Released in Vivo from the Caudate Nucleus and the Substantia Nigra of the Cat.- Release of 3H-5HT from Slices of Rat Substantia Nigra and Corpus Striatum in Vitro Mediated by Dopamine Receptors.- Serotonin Specific Adenylate Cyclase in Synaptosomal Membranes.- Substances Related to 5-Hydroxytryptamine in Plasma, Lumbar CSF, Venticular CSF and Frontal Cortex of Psychiatric Patients with and without Tryptophan Infusion.- Tryptophan Metabolism and 5HT in Schizophrenia.