Purine and Pyrimidine Metabolism in Man V

I. Adenosine Receptors.- Adenosine Receptors on Human T Lymphocytes and Human Thymocytes.- Adenosine Receptors on Human Lymphocytes.- Inhibition of Mast Cell Mediator Release by 5-Amino-4- Imidazolecarboxamide Riboside.- Purine Metabolism by Guinea Pig Ileum.- Suppression by Methylthioadenosine of Histamine or Leukotrienne-Induced Contraction in Isolated Guinea Pig Tracheal Rings.- Adenosine Receptors on Human Basophils and Lung Mast Cells.- II. Purine Receptors and the CNS.- Hypoxanthine Uptake by Isolated Brain Microvessels.- Morphine: Sites of Action in Guanosine Nucleoside Pathway.- Purine and Monoamine Metabolites in Cerebrospinal Fluid.- Characteristics of High Affinity and Low Affinity Adenosine Binding Sites in Human Cerebral Cortex.- III. Nucleoside and base Transport.- Hypoxanthine Transport Through Human Erythrocyte Membranes.- Regulatory Aspects of Hypoxanthine Uptake by Human Erythrocytes.- Mutant Mouse Cells with Nitrobenzulthioinosine-insensitive Nucleoside Transport Functions.- Carrier Mediated Uptake of Deoxyguanosine in Rat Liver Mitochondria.- IV. Studies with Anti-Metabolites.- Mechanism of Thymineless Death.- Enhancement of Methotrexate Cytotoxicity by Uracil Analogues that Inhibit Deoxyuridine Triphosphate Nucleotidohydrolase (dUTPase) Activity.- Influence of Methotrexate on Purine and Pyrimidine Pools and on Cell Phase Distribution of Cultured Human Lymphoblasts.- Modulation of Cytotoxicity and Metabolism of 5-Fluorouracil in Two Intestine Cell Lines.- Toxicity and Antitumor Effect of 5-Fluorouracil and Its Rescue by Uridine.- Synergy of Methotrexate and 6-Mercaptopurine in Cell Growth and Clonogenicity of Cultured Human T-Lymphoblasts.- Increased Availability of Phosphoribosyl Pyrophosphate as the Basis for Enhanced 6-Mercaptopurine Incorporation by Methotrexate, in Cultured Human Lymphoblasts.- Regulation of Deoxyadenosine and Nucleoside Analog Phosphorylation by Human Placental Adenosine Kinase.- The Biosynthesis of Deoxyguanosine Triphosphate in Herpes Simplex Type-1 Infected Vero Cells Treated with Acyclovir and Hydroxyurea.- 5-AZA-2’-Deoxycytidine Synergic Action with Thymidine on Leukemic Cells and Interaction of 5-AZA-dCMP with dCMP Deaminase.- Selection of Purine Nucleoside Analogs Based on Multiple Biological and Biochemical Parameters.- Effect of mAMSA on the Cellular Pharmacology of Ara-CTP in Human Leukemic Cells During Therapy with High- Dose Ara-C.- 5-Fluoro-5’-Deoxyuridine Is an Inhibitor of Uridylate Nucleotidase in L1210 Leukaemia.- V. Deoxynucleotide and Nucleoside Toxicity and Metabolism.- The Effect of Phosphonoformic Acid on Wild Type and Mutant S49 Cell Lines.- Mechanisms of Deoxyguanosine Toxicity for Human T and B Lymphocytes.- Role of Intracellular Deoxynucleoside Triphosphate Levels in DNA Repair in Human Lymphocytes.- Genetic Analysis of Deoxyadenosine Toxicity in Dividing Human Lymphoblasts.- Inhibition of 3H-Thymidine Incorporation by Adenosine and Deoxyadenosine in Human Peripheral Lymphocytes and Malignant Lymphoid Cell Lines.- S-Adenosylmathionine Metabolism as a Target for Adenosine Toxicity.- Ethanol Induced Nucleotide Catabolism in Mouse T Lympho- blastoid Cells In Vitro.- Increased Level of Ribonucleotide Reductase in Deoxy- adenosine Resistant Adenosine Deaminase Deficient Human Histiocytic Lymphoma Cells.- Inhibition of T Cell Cytotoxicity by Cyclosporine (CSA) Adenosine (ADO), and an Inhibitor of Adenosine Deaminase.- VI. Enzymes.- Mechanism of Urate Production by Guinea-Pig Ileum.- In Vitro Degradation of Pyrimidine Bases: Studies of Rat Liver Dihydropyrimidine Dehydrogenase.- Regulation of Enzymes by Ligand Induced Change in Polymerization.- Synthesis and Turnover of Purine Nucleoside Phosphorylase in Human Lymphocytes.- Reversible Interconversion Between Sulfo and Desulfo Xanthine Dehydrogenase.- Mammalian Mutants Genetically Altered in CTP Synthetase Activity.- Increased Inosinate Dehydrogenase Activity in Mycophenolic Acid Resistant Neuroblastoma Cells.- Murine Lymphocytes and Lymphocyte Lines Secrete Adenosine Deaminase.- Identification of a Purine 5?-Nucleotidase in Human Erythrocytes.- Human Placental Cytoplasmic 5?-Nucleotidase: Kinetics and Molecular Properties.- Regulation of the Cytosol 5?-Nucleotidase of the Heart by Adenylate Energy Charge.- Characterization of Hydroxyurea (HYU) Resistant S49 T Lymphoma Cells.- Purification and Properties of Human Deoxycytidine Kinase.- Purification of Mammalian Glycinamide Ribonucleotide (GAR) Synthetase.- Steady-State Kinetics of the Reaction Catalyzed by GMP Reductase.- Purine De Novo Synthesis and Salvage During Testicular Development in the Rat.- Pathways of Adenine Nucleotide Catabolism in Human Erythrocytes.- Mechanism of Increased Rate of De Novo Purine Biosynthesis in Rat Liver after Bilateral Adrenalectomy.- Increase of Amidophosphoribosyltransferase Activity and Phosphoribosylpyrophosphate Concentration as the Basis for Increased De Novo Purine Biosynthesis in the Regenerating Rat Liver.- Purine Metabolism in Human Neuroblastoma Cell Lines.- Purine Biosynthesis in Chinese Hamster Cell Mutants and Human Fibroblasts Partially Deficient in Adenylo- succinate Lyase.- Purine Synthetic Capacities of De Novo and Salvage Pathways in Rat Hepatoma 3924A Cells.- Metabolism of Purine Nucleotide in the Liver and Kidney of Castrated Rats.- The Hormonal Regulation of Purine Biosynthesis. Control of the Inosinic Acid Branch Point.- VII. purine and Pyrimidine Metabolism during Lymphocyte Differentiation.- Production and Properties of Monoclonal Antibodies Against Human Ecto-5?-Nucleotidase.- AMP-Deaminase and Cytosolic 5?-Nucleotidase in Human and Murine Lymphocyte Subpopulations.- An Explanation for the Heterogeneity in B Lymphocyte Ecto-5?-Nucleotidase Activity in Patients with Hypogammaglobulinemia.- Cell Surface Adenosine Deaminase (ADA) and Its Complexing Protein (ADCP) in Human T-Lymphoid Cells.- On the Role of Cytidine Deaminase in Cellular Metabolism.- Purine Enzyme Activities as Markers of Lymphocytic Differentiation: Studies of Lymphocytes from Horses with Severe Combined Immunodeficiency (SCID).- The Effects of PNP Inhibition on Rat Lymphoid Cell Populations.- Imbalance in Nucleotide Pools of Myeloid Leukemia Cells and HL-60 Cells: Correlation with Cell Cycle Phase, Cell Proliferation and Differentiation.- Enhancement of T Cell Proliferation and Differentiation by 8-Mercaptoguanosine.- Antigen-Specific Enhancement of the Human Antibody Response by a Substituted Nucleoside.- Ectoenzymes of Nucleotide Metabolism on Human Lymphoid Cells.- Separate Mechanisms for Cellular Uptake on Purine Nucleotides by B- and T-Lymphoblasts.- Ecto-5?-Nucleotidase Can Use IMP to Provide the Total Purine Requirements of Mitogen-Stimulated Human T Cells and Human B Lymphoblasts.- VIII. Purine Metabolism in Skeletal Muscle.- Changes of Purine Metabolism During Differentiation of Rat Heart Myoblasts.- Production and Degradation of AMP in Cultured Rat Skeletal and Heart Muscle: A Comparative Study.- Duchenne Muscular Dystrophy: Normal ATP Turnover in Cultured Cells.- Inferences on the Rapid Metabolism of Exogenously Applied ATP in Isolated Smooth Muscle Preparations Using Pharmacological Studies.- Enzyme Activities of Purine Catabolism and Salvage in Human Muscle Tissue.- Purine Salvage in Rat Heart Myoblasts.- Skeletal Muscle Adenosine, Inosine and Hypoxanthine Release Following Ishaemic Forearm Exercise in Myoadenylate Deaminase Deficiency and McArdle?s Disease.- Myoadenylate Deaminase Deficiency: Diagnosis by Forearm Ischemic Exercise Testing.- IX. Purine Nucleotide Metabolism in the Heart.- Purine Nucleotides in Human Hearts During Open Heart Surgery.- X. Purine and Pyrimidine Metabolism in Primary Cell Cultures and in Parasites.- Cell Culture Models for the Study of Purine Metabolism in Human Placental Tissue.- Purine Nucleotide Synthesis in Cultured Rat Embryos Undergoing Organogenesis.- Evidence for a Membrane Adenosine Receptor in LeishmaniaMexicanaMexicana (WR 227).- Adenine Phosphoribosyltransferase-Deficient LeishmaniaDonovani.- 5?-Methylthioadenosine (MTA) Phosphorylase from Promastigotes of Leishmania Donovani.- 6-Thiopurine Riboside Analogs: Their Toxicity and Metabolism in LeishmaniaDonovani and Mammalian Cells.- Purine Salvage Enzymes in Trichomonas Vaginalis.- XI. Nucleoside Kinases and Drug Activation.- Biochemical Basis for Deoxyadenosine and 2-Chlorodeoxy- adenosine Toxicity to Resting Human Lymphocytes.- 2-Chloroadenosine is Phosphorylated and Increases the Production of Hypoxanthine in Human Cells.- Mechanism of Cytotoxicity of 2-Chloro and 2-Bromodeoxy- adenosine for a Human Lymphoblastic Cell Line, CCRF-CEM.- Genetic and Biochemical Characteristics of Three Different Types of Mutants of Mammalian Cells Affected in Adenosine Kinase.- Characterization of Arabinosylguanine Resistance in a Lymphoblastoid Cell Line.- XII. Phosphoribosylpyrophosphate.- The Synthesis of Phosphoribosylpyrophosphate from Glucose Decreases During Amino Acid Starvation of Human Lymphoblasts.- Effect of Fructose on the Concentration of Phosphoribosylpyrophosphate in Isolated Hepatocytes.- The Mechanism of Insulin-Induced Increase of the Rate of De Novo Purine Biosynthesis in Primary Cultured Rat Hypatocytes.- Hormone-Induced Stimulation of Phosphoribosylpyrophosphate and of Purine Synthesis in Mouse Liver In Vivo.- XIII. S-Adenosylmethionine Metabolism.- Cobalamin Inactivation Decreases Purine and Methionine Synthesis in Cultured Human Lymphoblasts.- 5?-Deoxy-5?-Methylthioadenosine Phosphorylase Deficiency in Leukemia: Genetics and Biochemical Aspects.- Metabolism of 5?-Methylthioadenosine in Methionine- Dependent and Methionine-Independent Cells.- Inhibition of De Novo Purine Synthesis by Methylthioadenosine.- Determination of S-Adenosylhomocysteine in Tissues Following Pharmacological Inhibition of S-Adenosylhomocysteine Catabolism.- 4?-Thioadenosine as a Novel Inhibitor of S-Adenosylhomocysteine Hydrolase and an Inducer for the Differentiation of HL-60 Human Cells.- In Vivo Inhibition of Mouse Liver Methyltransferase Enzymes Following Treatment with 2?Deoxycoformycin and 2?Deoxyadenosine.- XIV. Interferon.- Alteration of Ribonucleotide and Deoxyribonucleotide Metabolism by Interferon in Human B-Lymphoblastoid Cells.- Inhibitor of 2/, 5/-01igoadenylate Synthetase Induced in Human T Lymphoblastoid Cell Line Treated with Deoxyadenosine, Deoxycoformycin and Interferon.- 2-5A Synthetase Activities in Herpes Virus Infection and After Interferon Treatment.- Contributors.