Nikolay V Dokholyan
Springer New York
2012e druk, 2012
9781461421450
Computational Modeling of Biological Systems
From Molecules to Pathways
Specificaties
Gebonden, 366 blz.
|
Engels
Springer New York |
2012e druk, 2012
ISBN13: 9781461421450
Rubricering
Onderdeel van serie
Biological and Medical Physics, Biomedical Engineering
Verwachte levertijd ongeveer 8 werkdagen
Samenvatting
Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant systems.
Specificaties
ISBN13:9781461421450
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:366
Uitgever:Springer New York
Druk:2012
Inhoudsopgave
Part I. Molecular Modeling.- Chapter 1. Introduction to Molecular Dynamics: Theory and Applications in Biomolecular Modeling.- Chapter 2. The Many Faces of Structure-Based Potentials: From Protein Folding Landscapes to Structural Characterization of Complex Biomolecules.- Chapter 3. Discrete Molecular Dynamics Simulation of Biomolecules.- Chapter 4. Small Molecule Docking from Theoretical Structural Models.- Chapter 5. Homology Modeling: Generating Structural Models to Understand Protein Function and Mechanism.- Chapter 6. Quantum Mechanical Insights into Biological Processes at the Electronic Level.- Part II. Modeling Macromolecular Assemblies.- Chapter 7. Multiscale Modeling of Virus Structure, Assembly and Dynamics.- Chapter 8. Mechanisms and Kinetics of Amyloid Aggregation Investigated by a Phenomenological Coarse-Grained Model.- Chapter 9. The Structure of Intrinsically Disordered Peptides Implicated in Amyloid Diseases: Insights from Fully Atomistic Simulations.- Part III. Modeling Cells and Cellular Pathways.- Chapter 10. Computer Simulations of Mechano-Chemical Networks: Choreographing Actin Dynamics in Cell Motility.- Chapter 11. Computational and Modeling Strategies for Cell Motility.- Chapter 12. Theoretical Analysis of Molecular Transport Across Membrane Channels and Nanopores.- Part IV. Modeling Evolution.- Chapter 13. Modeling Protein Evolution.- Chapter 14. Modeling Structural and Genomic Constraints in the Evolution of Proteins.- Chapter 15. Modeling Proteins at the Interface of Structure, Evolution, and Population Genetics.