LeRoy E. Rabbani
Springer US
0e druk, 2012
9781461373612
Applications of Antisense Therapies to Restenosis
Specificaties
Paperback, 184 blz.
|
Engels
Springer US |
0e druk, 2012
ISBN13: 9781461373612
Rubricering
Onderdeel van serie
Perspectives in Antisense Science
Levertijd ongeveer 8 werkdagen
Samenvatting
Restenosis, the proliferation of smooth muscle cells (SMC) that line blood vessels, often follows angioplasty. Despite advances in cardiology, restenosis continues to affect up to 40% of the over 500,000 patients who undergo angioplasty each year.
Applications of Antisense Therapies to Restenosis is the first volume to address the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting. The work critically examines the application of various antisense therapies for inhibiting restenosis.
Specificaties
ISBN13:9781461373612
Taal:Engels
Bindwijze:paperback
Aantal pagina's:184
Uitgever:Springer US
Inhoudsopgave
1 Restenosis: The Clinical Problem.- 2 The Pathobiology of Restenosis. A Paradigm from Clinical and Experimental Studies.- 3 Coronary Repair and Restenosis Cellular Basis for Antisense Approaches.- 4 Vascular Smooth Muscle Cell Biology and Restenosis.- 5 Vascular Antisense Therapy Directed Against c-myc, c-myb, and PCNA.- 6 Phosphorothioate Oligodeoxynucleotides as Inhibitors of gene Expression: Antisenseand Non-Antisense Effects.- 7 Molecular Therapies for Vascular Disease: Altering the Balance Between Cell growth and Cell Death.- 8 Oligonucleotides Containing the G-Quartet Sequence Motif.- 9 Non-G-Quartet, Non-Sequence Specific Antirestenotic Effects of Phosphorothioate Oligodeoxynucleotides.- 10 Local Delivery of Antirestenotic Drugs.- 11 Critical Considerations and Future Directions.