I. The Endothelium.- 1 Endothelium-Derived Relaxing Factor:An Overview.- 2 Ionic Mechanisms of Peptide-Induced Responses in Vascular Endothelial Cells.- 3 Non-cGMP, Paracrine Effects of Nitric Oxide in the Vasculature.- 4 The Endothelin Peptides:Roles in Physiology and Pathophysiology.- 5 Estrogen and Vascular Reactivity.- 6 C-Type Natriuretic Peptide:The Vascular Component of the Natriuretic Peptide System.- 7 Vascular Actions of Insulin in Health and Disease:Role of the Endothelium.- 8 Angiotensin—Nitric Oxide:Interaction and the Regulation of Renal Vascular Tone.- 9 Altered Endothelial Function in Diabetes Mellitus:An Overview.- 10 Vascular Abnormalities in Diabetes Mellitus.- 11 Effects of Hyperglycemia on Vascular Endothelium Nitric Oxide Metabolism.- 12 Evidence Linking Fatty Acids, the Risk Factor Cluster, and Vascular Pathophysiology:Implications for the Diabetic Hypertensive Patient.- 13 Effects of Low Density Lipoproteins on Endothelial Cell Signaling and Adhesion Molecule Expression.- II. Vascular Smooth Muscle Cells.- 14 Angiotensin II Signal Transduction in Vascular Smooth Muscle.- 15 The Vascular Renin System.- 16 Effects of Insulin on Vascular Smooth Muscle Contraction.- 17 Sex Hormones and the Vasculature.- 18 Vitamin D and the Vessel Wall.- 19 Vascular Action Natriuretic Peptide Receptors.- 20 A Novel Vascular Hormone:Adrenomedullin.- 21 Calcium and Magnesium in the Regulation of Smooth Muscle Function and Blood Pressure:The Ionic Hypothesis of Cardiovascular and Metabolic Diseases and Vascular Aging.- 22 Regulation of Intracellular pH and the Na+/H+Antiporter in Vascular Smooth Muscle.- 23 Endocrine Regulation of Vascular Smooth Muscle Intermediary Metabolism.- 24 Analogy Between Endothelial/Mesangial Cell and Endothelial/Vascular Smooth Muscle CellInteractions:Role of Growth Factors and Mechanotransduction.- 25 Arachidonic Acid Metabolites in the Vasculature.- 26 Arachidonic Acid Metabolites on Renin and Vascular Smooth Muscle Cell Growth.