Introduction: HLA, Plagues and People.- Section I: Autoimmune and Immunopathological Diseases.- 1 Streptococci and Rheumatic Heart Disease.- 2 Viruses and Myocarditis.- 3 The Role of Environmental Factors in Modulating Insulin Dependent Diabetes.- 4 The Role of the Microflora in Graft-versus-Host Disease After Allogeneic Bone Marrow Transplantation.- Section II: Malignancies.- 5 Human T Lymphotropic Retroviruses: Pathological Consequences of Infection.- 6 Viruses, Oncogenes and Cancer.- 7 Epstein-Barr Virus Infection and Cancer.- Section III: Mechanisms and their Implications for Prevention and Therapy.- 8 Chronic Infection, Immunopathology and Immune Suppression.- 9 What Drives Autoantibodies? The Evidence From Spontaneous Human Autoimmune Diseases.- 10 What are the Immunogens That Incite the Autoantibodies of Systemic Lupus Erythematosus?.- 11 Inappropriate HLA Molecule Expression in Epithelial Cells: Relevance for Human Autoimmunity.- 12 Molecular Mimicry in Autoimmune Disease.- 13 A Heat Shock Protein, Molecular Mimicry and Autoimmunity.- 14 What Do Human T Cells See in the Mycobacterial 65 kDa Heat Shock Protein?.