Innovative Research in Life Sciences – Pathways to Scientific Impact, Public Health Improvement, and Economic Progress
Pathways to Scientific Impact, Public Health Improvement, and Economic Progress
Samenvatting
I thoroughly enjoyed reading this book as it has taken me on a journey through time, across the globe and through multiple disciplines. Indeed, we need to be thinking about these concepts and applying them every day to do our jobs better.
Farah Magrabi, Macquarie University, Australia
The reader will find intriguing not only the title but also the content of the book. I m also pleased that public health, and even more specifically epidemiology has an important place in this ambitious discussion.
Elena Andresen, Oregon Health & Science University, USA
This book is very well written and addresses an important topic. It presents many reasons why basic scientists/researchers should establish collaborations and access information outside traditional means and not limit thinking but rather expand such and perhaps develop more innovative and translational research ventures that will advance science and not move it laterally.
Gerald Pepe, Eastern Virginia Medical School, USA
This book gathers logically and presents interestingly (with many examples) the qualities and attitudes a researcher must possess in order to become successful. On the long run, the deep and carefully reexamined research will be the one that lasts.
Zoltán Néda, Babe –Bolyai University, Romania
I really liked the five pillars delineating the components of humanism in research. This book has made a major contribution to the research ethics literature.
David Fleming, University of Missouri, USA
A comprehensive review of the research phase of life sciences from design to discovery with suggestions to improve innovation
This vital resource explores the creative processes leading to biomedical innovation, identifies the obstacles and best practices of innovative laboratories, and supports the production of effective science. Innovative Research in Life Sciences draws on lessons from 400 award–winning scientists and research from leading universities. The book explores the innovative process in life sciences and puts the focus on how great ideas are born and become landmark scientific discoveries. The text provides a unique resource for developing professional competencies and applied skills of life sciences researchers.
The book examines what happens before the scientific paper is submitted for publication or the innovation becomes legally protected. This phase is the most neglected but most exciting in the process of scientific creativity and innovation. The author identifies twelve competencies of innovative biomedical researchers that described and analyzed. This important resource:
Highlights the research phase from design to discovery that precedes innovation disclosure
Offers a step by step explanation of how to improve innovation
Offers solutions for improving research and innovation productivity in the life sciences
Contains a variety of statistical databases and a vast number of stories about individual discoveries
Includes a process of published studies and national statistics of biomedical research and reviews the performance of research labs and academic institutions
Written for academics and researchers in biomedicine, pharmaceutical science, life sciences, drug discovery, pharmacology, Innovative Research in Life Sciences offers a guide to the creative processes leading to biomedical innovation and identifies the best practices of innovative scientists and laboratories.
Specificaties
Inhoudsopgave
<p>1. Pathways of the Research Innovator 13</p>
<p>Diverse outcomes of science 14</p>
<p>Best of both worlds: scientific and innovative 15</p>
<p>Seek research opportunities that are not just timely but also timeless. 16</p>
<p>Balancing research and innovation 17</p>
<p>Essential concepts of research innovation 19</p>
<p>Research innovation pathways to effects 20</p>
<p>Learning from award–winning scientists and serial innovators 22</p>
<p>Road to meaningful research disclosure 24</p>
<p>2. First Dimension: Scientific Impact 29</p>
<p>Intellectual impact and scientific pluralism 29</p>
<p>You can′t make a good landing out of a bad approach 31</p>
<p>Intellectual products of scientific endeavors 33</p>
<p>Reality means reproducability 37</p>
<p>One may not know in the beginning how the end will look like 38</p>
<p>3. Second dimension: Public health value 44</p>
<p>Improving health in mission statements of science 45</p>
<p>The road from basic research to better health 46</p>
<p>Breaking down silos: basic science and public health 48</p>
<p>Putting science to work and change lives 50</p>
<p>High–impact research driven by public health needs 51</p>
<p>4. Third dimension: Economic development 59</p>
<p>Economic impact of life sciences research 60</p>
<p>Blockbuster impact of university research 61</p>
<p>Good science must come first in commercialization 64</p>
<p>Without good science, there is no positive technology transfer 65</p>
<p>Impact of life sciences on the national economy 67</p>
<p>Diverse messages about economic impact at different levels 68</p>
<p>5. Slowdown and erosion 74</p>
<p>Signs of slowdown in research innovation 75</p>
<p>Obstacles to research innovation 76</p>
<p>Increasing costs of regulatory compliance 79</p>
<p>The gamble of science and shortermism′ 80</p>
<p>Sputnik moment: the need to accelerate research 82</p>
<p>6. Non–reproducible research 90</p>
<p>The boulder of non–reproducible research 91</p>
<p>Implications of non–reproducible results 92</p>
<p>Sources of non–repeatable research results 94</p>
<p>Rare but troubling: pathological science and fraudulent research 99</p>
<p>The way out: modeling, transparency and continuous quality improvement 101</p>
<p>7. Red tape and litigation 108</p>
<p>Bureaucratization of research 109</p>
<p>Regulatory burden on creativity 113</p>
<p>Protection of intellectual property 115</p>
<p>Conflicts over credit and case law of inventor recognition 116</p>
<p>Accountability for reproducibility 120</p>
<p>8. Humanism for Innovation 127</p>
<p>Research targeting by values of humanism 128</p>
<p>Identifying measures for performance improvement 130</p>
<p>Creativity needs diversity of people, cultures, and ideas 132</p>
<p>Rock solid values when the controversies mount 133</p>
<p>Counteracting flawed economic and social incentives 135</p>
<p>Focus and motivation for sacrificial effort 136</p>
<p>Numbers need stories and stories need numbers 137</p>
<p>9. Desire to understand first 142</p>
<p>We will surpass on the gray matter 142</p>
<p>Research talent needs scientific opportunity 144</p>
<p>Curiosity and research agenda 145</p>
<p>Be passionate without emotions 147</p>
<p>The power of logic and abstraction 148</p>
<p>Creativity and divergent thinking 150</p>
<p>Winning science: who gets the award? 151</p>
<p>Reading scientific papers is more difficult than writing them 152</p>
<p>10. Learning from the Best 158</p>
<p>The benefits of research mentoring 159</p>
<p>The mentored way to success 160</p>
<p>Mentoring minority students and researchers 162</p>
<p>Learn from leaders to become a leader 165</p>
<p>11. Cracking Public Health Needs 171</p>
<p>Epidemiology triggers basic research 172</p>
<p>Scientific assumptions meet the brutal truth of epidemics 174</p>
<p>Curiosity–driven research enlists epidemiology 175</p>
<p>The unparalleled value of retrospective studies 178</p>
<p>12. Engaged Research Science confronts the bubble bias 184</p>
<p>Resources and indispensable benefits of engaged research 185</p>
<p>Prolific partnerships of arguers 188</p>
<p>Talking through to achieve understanding 189</p>
<p>Academic engagement with the community 190</p>
<p>Corporate competence in life sciences 191</p>
<p>Team science and collaborative research 194</p>
<p>Bouncing ideas in the real world 195</p>
<p>13. Cross–cultural Convergence 200</p>
<p>International collaborations and mobility 201</p>
<p>Convergence of disciplines 203</p>
<p>Evolution of team science 206</p>
<p>If you have never been in minority, you have never said anything original 208</p>
<p>14. Targeting and Repurposing 213</p>
<p>Consequential research generates value to others 213</p>
<p>Targeting mechanisms goes beyond observation 215</p>
<p>Repurposing what is already known 216</p>
<p>Eureka moment of discovering the unexpected 218</p>
<p>From serendipity to practical applications 220</p>
<p>15. Trailblazing Technologies 225</p>
<p>Behind every great discovery, there is an elegant methodology 225</p>
<p>Sought after technique becomes the goal of research and development 228</p>
<p>The technical opportunity presents itself to the researcher 230</p>
<p>When the industrial designer decides to serve public health 232</p>
<p>16. Emulating Nature 238</p>
<p>Scanning nature for valuable compounds 238</p>
<p>Studying how nature solves the problem 241</p>
<p>Learning from the unexpected outlier 242</p>
<p>Intertwining ring of evidence 245</p>
<p>17. Scientific Modeling 250</p>
<p>Hallmarks of the scientific modeling 251</p>
<p>Scholarly intuition and triple evidence 255</p>
<p>Validation and refinement 256</p>
<p>Choosing models to understand how nature works 257</p>
<p>Understanding processes leads to practical solutions 260</p>
<p>18. Mastering Bioentrepreneurship 265</p>
<p>Catching the semi–truck: Researcher gets the first large grant 265</p>
<p>Commercialization of research products and byproducts 268</p>
<p>Outreach, elevator pitch and marketing 271</p>
<p>Planning for customer acquisition 274</p>
<p>Pipeline of life sciences innovation: assets to returns 276</p>
<p>19. Art of Scientific Communication 281</p>
<p>Yardstick of communication: original research report 282</p>
<p>Learning from examples and feedback 284</p>
<p>Evidence–based writing: sentences and paragraphs 286</p>
<p>Time honored structure of scientific manuscripts 288</p>
<p>Quality control: testing the manuscript before release 292</p>
<p>Publishing a research paper is not mission accomplished 294</p>
<p>20. Quality and performance improvement 300</p>
<p>Quality control looks at populations and organizations 301</p>
<p>Cycle of quality improvement in the research enterprise 304</p>
<p>Quality disposition of research projects 306</p>
<p>Measures of success in scientific research 306</p>
<p>21. Institutional and national strategies 313</p>
<p>Institutional opportunities to support research 313</p>
<p>Recruitment and retention of research faculty 317</p>
<p>Peer–comparisons of research productivity 319</p>
<p>Catapults of success: education of the youth 322</p>
<p>Evidence–based public policies for the knowledge society 323</p>
<p>22. International collaboration and competition 330</p>
<p>The flagship role of research universities 331</p>
<p>The next Silicon Valleys: what works and how it works 333</p>
<p>Scientific innovation and economic competition 336</p>
<p>International variation in research policies 337</p>
<p>Global networks to accelerate research 338</p>
<p>Innovative minds with a sense of social and global responsibility 339</p>
<p>List of scientists and serial innovators 344</p>
<p>List of concepts and terms 349</p>