Cancer Cytogenetics – Chromosomal and Molecular Genetic Aberrations of Tumor Cells 4e
Chromosomal and Molecular Genetic Aberrations of Tumor Cells
Samenvatting
The first three editions of this acclaimed book presented a much–needed conceptual synthesis of this rapidly moving field. Now,
Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up–to–date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations.
New contributors reflecting broader international authorship and even greater expertise
Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations
Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date
Now produced in full color for enhanced clarity
Covers how molecular genetic data (PCR–based and sequencing information) are collated with the cytogenetic data where pertinent
Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible
Specificaties
Inhoudsopgave
<p>Preface to the Fourth Edition ix</p>
<p>1 How it all began: cancer cytogenetics before sequencing 1<br />Felix Mitelman and Sverre Heim</p>
<p>2 Cytogenetic methods 11<br />David Gisselsson</p>
<p>3 Cytogenetic nomenclature 19<br />Sverre Heim and Felix Mitelman</p>
<p>4 Nonrandom chromosome abnormalities in cancer: an overview 26<br />Sverre Heim and Felix Mitelman</p>
<p>5 From chromosomes to genes: searching for pathogenetic fusions in cancer 42<br />Ioannis Panagopoulos</p>
<p>6 Acute myeloid leukemia 62<br />Bertil Johansson and Christine J. Harrison</p>
<p>7 Myelodysplastic syndromes 126<br />Harold J. Olney and Michelle M. Le Beau</p>
<p>8 Chronic myeloid leukemia 153<br />Thoas Fioretos</p>
<p>9 Chronic myeloproliferative neoplasms 175<br />Peter Vandenberghe and Lucienne Michaux</p>
<p>10 Acute lymphoblastic leukemia 198<br />Christine J. Harrison and Bertil Johansson</p>
<p>11 Mature B ] and T ]cell neoplasms and Hodgkin lymphoma 252<br />Reiner Siebert and Sietse M. Aukema</p>
<p>12 Tumors of the upper aerodigestive tract 332<br />Susanne M. Gollin</p>
<p>13 Tumors of the lung 361<br />Penny Nymark, Eeva Kettunen and Sakari Knuutila</p>
<p>14 Tumors of the digestive tract 373<br />Georgia Bardi and Sverre Heim</p>
<p>15 Tumors of the urinary tract 401<br />Paola Dal Cin</p>
<p>16 Tumors of the breast 426<br />Manuel R. Teixeira, Nikos Pandis and Sverre Heim</p>
<p>17 Tumors of the female genital organs 447<br />Francesca Micci and Sverre Heim</p>
<p>18 Tumors of the male genital organs 481<br />Manuel R. Teixeira and Sverre Heim</p>
<p>19 Tumors of endocrine glands 497<br />Jörn Bullerdiek and David Gisselsson</p>
<p>20 Tumors of the nervous system 515<br />Petter Brandal and Sverre Heim</p>
<p>21 Tumors of the eye 538<br />Karen Sisley</p>
<p>22 Tumors of the skin 555<br />Fredrik Mertens, Felix Mitelman and Sverre Heim</p>
<p>23 Tumors of bone 566<br />Fredrik Mertens and Nils Mandahl</p>
<p>24 Soft tissue tumors 583<br />Nils Mandahl and Fredrik Mertens</p>
<p>Index 615</p>