General and Molecular Pharmacology – Principles of Drug Action

<p>LIST OF CONTRIBUTORS xlvi<br /><br />Preface xlix<br /><br />SECTION 1 INTRODUCTION TO PHARMACOLOGY 1<br /><br />1 Essential Lexicon of Pharmacology 3<br />Francesco Clementi and Guido Fumagalli<br /><br />2 A Short History of Pharmacology 8<br />Vittorio A. Sironi<br /><br />SECTION 2 GETTING THE DRUG TO ITS SITE OF ACTION 19<br /><br />3 Cellular Basis of Pharmacokinetics 21<br />Riccardo Fesce and Guido Fumagalli<br /><br />4 Drug Absorption and Administration Routes 31<br />Riccardo Fesce and Guido Fumagalli<br /><br />5 Drug Distribution and Elimination 45<br />Riccardo Fesce and Guido Fumagalli<br /><br />6 Drug Metabolism 61<br />Enzo Chiesara Laura Marabini and Sonia Radice Metabolic Modification of Drug Activity <br /><br />7 Control of Drug Plasma Concentration 73<br />Riccardo Fesce and Guido Fumagalli<br /><br />SECTION 3 RECEPTORS AND SIGNAL TRANSDUCTION 91<br /><br />8 Drug Receptor Interactions: Quantitative and Qualitative Aspects 93<br />Gian Enrico Rovati and Val&eacute;rie Capra<br /><br />9 Receptors and Modulation of Their Response 109<br />Francesco Clementi and Guido Fumagalli<br /><br />10 A daptation to Drug Response and Drug Dependence 121<br />Cristiano Chiamulera<br /><br />11 Pharmacological Modulation of Posttranslational Modifications 130<br />Monica Di Luca Flavia Valtorta and Fabrizio Gardoni<br /><br />12 Calcium Homeostasis Within the Cells 139<br />Jacopo Meldolesi and Guido Fumagalli<br /><br />13 Pharmacology of Map Kinases 147<br />Lucia Vicentini and Maria Grazia Cattaneo<br /><br />14 Small G Proteins 154<br />Erzs&eacute;bet Ligeti and Thomas Wieland<br /><br />15 Integration in Intracellular Transduction of Receptor Signals 166<br />Jacopo Meldolesi<br /><br />SECTION 4 RECEPTOR CLASSES 173<br /><br />16 Ligand–Gated Ion Channels 175<br />Cecilia Gotti and Francesco Clementi<br /><br />17 G–Protein–Coupled Receptors 189<br />Lucia Vallar Maria Pia Abbracchio and Lucia Vicentini<br /><br />18 Growth Factor Receptors 202<br />Silvia Giordano Carla Boccaccio and Paolo M. Comoglio<br /><br />19 Cytokine Receptors 217<br />Massimo Locati<br /><br />20 A dhesion Molecule Receptors 225<br />Giorgio Berton and Carlo Laudanna<br /><br />21 Soluble Cytokine Receptors and Monoclonal Antibodies in Pathophysiology and Therapy 235<br />Alberto Mantovani and Annunciata Vecchi<br /><br />SECTION 5 MODULATION OF GENE ESPRESSION 241<br /><br />22 Pharmacology of Transcription 243<br />Roberta Benfante and Diego Fornasari<br /><br />23 Pharmacogenetics and Personalized Therapy 256<br />Diego Fornasari<br /><br />24 Intracellular Receptors 268<br />Adriana Maggi and Elisabetta Vegeto<br /><br />25 Rna Molecule as a Drug: From Rna Interference to Aptamers 284<br />Valerio Fulci and Giuseppe Macino<br /><br />SECTION 6 REGENERATIVE MEDICINE 293<br /><br />26 Regenerative Medicine and Gene Therapy 295<br />Luciano Conti and Elena Cattaneo<br /><br />SECTION 7 PHARMACOLOGICAL CONTROL OF MEMBRANE TRANSPORT 309<br /><br />27 Ion Channels 311<br />Maurizio Taglialatela and Enzo Wanke<br /><br />28 Membrane Transporters 345<br />Lucio Annunziato Giuseppe Pignataro and Gianfranco Di Renzo<br /><br />29 Neurotransmitter Transporters 359<br />Gaetano Di Chiara<br /><br />SECTION 8 CONTROL OF PROTEOLYSIS 377<br /><br />30 Intracellular Proteolysis 379<br />Fabio Di Lisa and Edon Melloni<br /><br />31 Extracellular Proteolysis 395<br />Francesco Blasi<br /><br />SECTION 9 CONTROL OF CELL CYCLE AND CELLULAR PROLIFERATION 403<br /><br />32 Cell Cycle and Cell Death 405<br />Marco Corazzari and Mauro Piacentini<br /><br />33 Mechanisms of Action of Antitumor Drugs 415<br />Giovanni Luca Beretta Laura Gatti and Paola Perego<br /><br />SECTION 10 CONTROL OF CELLULAR METABOLISM 431<br /><br />34 Mitochondria Oxidative Stress and Cell Damage: Pharmacological Perspectives 433<br />Clara De Palma Orazio Cantoni and Fabio Di Lisa<br /><br />35 Pharmacological Control of Lipid Synthesis 439<br />Lorenzo Arnaboldi Alberto Corsini and Nicola Ferri<br /><br />36 Glucose Transport and Pharmacological Control of Glucose Metabolism 452<br />Paolo Moghetti and Giacomo Zoppini<br /><br />SECTION 11 INTERCELLULAR COMMUNICATION 463<br /><br />37 Pharmacological Regulation of Synaptic Function 465<br />Michela Matteoli Elisabetta Menna Costanza Capuano and Claudia Verderio<br /><br />38 Catecholaminergic Transmission 477<br />Pier Franco Spano Maurizio Memo M. Cristina Missale Marina Pizzi and Sandra Sigala<br /><br />39 Cholinergic Transmission 496<br />Giancarlo Pepeu<br /><br />40 The Serotonergic Transmission 509<br />Maurizio Popoli Laura Musazzi and Giorgio Racagni<br /><br />41 Histaminergic Transmission 520<br />Emanuela Masini and Laura Lucarini<br /><br />42 Gabaergic Transmission 529<br />Mariangela Serra Enrico Sanna and Giovanni Biggio<br /><br />43 Glutamate–Mediated Neurotransmission 541<br />Flavio Moroni<br /><br />44 Purinergic Transmission 553<br />Stefania Ceruti Flaminio Cattabeni and Maria Pia Abbracchio<br /><br />45 Neuropeptides 565<br />Lucia Negri and Roberta Lattanzi<br /><br />46 The Opioid System 572<br />Patrizia Romualdi and Sanzio Candeletti<br /><br />47 The Endocannabinoid System 585<br />Daniela Parolaro and Tiziana Rubino<br /><br />48 Pharmacology of Nitric Oxide 596<br />Emilio Clementi<br /><br />49 A rachidonic Acid Metabolism 608<br />Carlo Patrono and Paola Patrignani<br /><br />SECTION 12 PHARMACOLOGY OF DEFENCE PROCESSES 623<br /><br />50 Pharmacological Modulation of the Immune System 625<br />Carlo Riccardi and Graziella Migliorati<br /><br />51 Mechanism of Action of Anti–Infective Drugs 641<br />Francesco Scaglione<br /><br />SECTION 13 TOXICOLOGY AND DRUG INTERACTIONS 663<br /><br />52 Introduction to Toxicology 665<br />Helmut Greim<br /><br />53 Drug Interactions 678<br />Achille P. Caputi Giuseppina Fava and Angela De Sarro<br /><br />SECTION 14 DRUG DEVELOPMENT 687<br /><br />54 Preclinical Research and Development of New Drugs 689<br />Ennio Ongini<br /><br />55 Role of Drug Metabolism and Pharmacokinetics in Drug Development 700<br />Simone Braggio and Mario Pellegatti<br /><br />56 Clinical Development of a New Drug and Methodology of Drug Trials 708<br />Carlo Patrono<br /><br />Index 714</p>