Translational Gastroenterology – Organogenesis to Disease
Organogenesis to Disease
Samenvatting
Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tissue engineering of GI organs. The topics covered provide a unique window onto current activity in the field of gastroenterology, fostering enhanced knowledge for developmental biologists as well as for clinical practitioners. Notable features include the following: • Basic science chapters review the molecular and cellular pathways of GI organ development alongside clinical chapters examining organ–based diseases, closing the gap between the bench and the clinic. • Derivative organs – esophagus, stomach, pylorus, small intestine, colon, liver, and pancreas –as well as tissues such as serosa and enteric nervous system that are common to multiple GI organs. • Chapters detailing the use of model organisms – Drosophila, sea urchin, zebrafish, C. elegans, Xenopus – for basic discovery studies are included. • Chapters on GI stem cells and the potential for tissue engineering of the GI organs provide a view to the future of research and therapy in these organs.
Specificaties
Inhoudsopgave
<p>Foreword xiii</p>
<p>Preface xv</p>
<p>1 Endoderm Development: From Progenitors to Organ Buds 1<br />David A.F. Loebel, Keren Kaufman–Francis, Yoji Kojima, Henry C.Y. Chung, and Patrick P.L. Tam</p>
<p>2 Genetic and Cellular Mechanisms Regulating Esophageal Development 15<br />Wei–Yao Ku and Jianwen Que</p>
<p>3 Congenital and Acquired Diseases of the Esophagus 27<br />Iljana Gaffar, Yousef El–Gohary, and George Gittes</p>
<p>4 Basic Science of Stomach Development 43<br />Tae–Hee Kim and Ramesh A. Shivdasani</p>
<p>5 Congenital and Acquired Diseases of the Stomach 57<br />Ramon U. Jin and Jason C. Mills</p>
<p>6 The Pylorus: Development and Disease 73<br />Ajay Prakash, Aaron M. Udager, and Deborah L. Gumucio</p>
<p>7 Basic Science of Small Intestinal Development 85<br />Cayla A. Thompson and Michele A. Battle</p>
<p>8 Clinical Small Intestine 99<br />Michael A. Helmrath and Kavita Deonarine</p>
<p>9 Basic Science of Colon Development 113<br />Mattheus C.B. Wielenga and Gijs R. van den Brink</p>
<p>10 Congenital and Acquired Diseases of the Colon 125<br />Jennifer J. Freeman and Daniel H. Teitelbaum</p>
<p>11 Intestinal Serosa 139<br />Nichelle I. Winters and David M. Bader</p>
<p>12 Basic Science of Liver Development 151<br />Ann DeLaForest and Stephen A. Duncan</p>
<p>13 Congenital and Acquired Diseases of the Liver 165<br />Zahida Khan, Edgar N. Tafaleng, Kyle A. Soltys, and Ira J. Fox</p>
<p>14 Developmental Biology of the Pancreas 179<br />L. Charles Murtaugh</p>
<p>15 Congenital Disorders of the Pancreas 193<br />Mark Lowe</p>
<p>16 Enteric Nervous System Development 209<br />E. Michelle Southard–Smith and Melissa A. Musser</p>
<p>17 Congenital and Acquired Disorders of the Enteric Nervous System 225<br />Robert O. Heuckeroth</p>
<p>18 Gut Development in the Sea Urchin 241<br />Megan L. Martik and David R. McClay</p>
<p>19 Intestinal Stem Cell Specification in the Drosophila Midgut 253<br />Neus Rafel and Benjamin Ohlstein</p>
<p>20 The Caenorhabditis elegans Intestine 263<br />James D. McGhee, Tobias Wiesenfahrt, and Aidan E. Dineen</p>
<p>21 Xenopus as a Model for GI Development 275<br />Zheng Zhang and Aaron M. Zorn</p>
<p>22 Zebrafish Models of GI Development and Disease 289<br />Ashley Alvers and Michel Bagnat</p>
<p>23 Gastrointestinal Stem Cells 303<br />Elise S. Demitrack and Linda C. Samuelson</p>
<p>24 Translating Embryonic Development into Models of Human Gastrointestinal Development and Disease 317<br />Stacy R. Finkbeiner and Jason R. Spence</p>
<p>Index 327</p>