Natanya Civjan,
N Civjan
John Wiley & Sons
e druk, 2012
9781118101186
Chemical Biology – Approaches to Drug Discovery and Development to Targeting Disease
Approaches to Drug Discovery and Development to Targeting Disease
Specificaties
Gebonden, 524 blz.
|
Engels
John Wiley & Sons |
e druk, 2012
ISBN13: 9781118101186
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Based on the award–winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. This book is a top–notch guide and reference for anyone working in the areas of drug discovery and development.
Specificaties
Inhoudsopgave
<p>Contributors xi</p>
<p>PART I DRUG DISCOVERY AND DEVELOPMENT 1</p>
<p>1 The Role of Chemical Biology in Drug Discovery 3<br /> Andrew J. Pope</p>
<p>2 Computational Approaches to Drug Discovery and Development 23<br /> Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu, and Hualiang Jiang</p>
<p>3 Design and Selection of Small Molecule Inhibitors 41<br /> Jianwei Che, Yi Liu, and Nathanael S. Gray</p>
<p>4 Lead Optimization in Drug Discovery 65<br /> Craig W. Lindsley, David Weaver, Thomas M. Bridges, and J. Phillip Kennedy</p>
<p>5 Pharmacokinetics of Drug Candidates 83<br /> Ronald E. White</p>
<p>6 ADME Properties of Drugs 101<br /> Li Di and Edward H. Kerns</p>
<p>7 Drug Transport in Living Systems 115<br /> Yael Elbaz and Shimon Schuldiner</p>
<p>8 Blood–Brain Barrier: Considerations in Drug Development and Delivery 133<br /> David S. Miller and Brian T. Hawkins</p>
<p>9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery 147<br /> Zhong Zuo and Vincent H. L. Lee</p>
<p>10 Pharmaceuticals: Natural Products and Natural Product Models 165<br /> Sheo B. Singh</p>
<p>PART II CHEMICAL BIOLOGY TO UNDERSTAND AND TARGET DISEASE 203</p>
<p>11 The Role of Chemical Biology in Understanding and Treating<br /> Disease Are Small Molecule Correctors the Way of the Future? 205<br /> David Selwood</p>
<p>12 Anxiety Disorders 215<br /> Miklos Toth</p>
<p>13 Chronic Obstructive Pulmonary Disease (COPD) 245<br /> Peter J. Barnes</p>
<p>14 Depression 267<br /> Glen B. Baker and Nicholas D. Mitchell</p>
<p>15 Osteoarthritis 293<br /> Marjolaine Gosset, Jeremie Sellam, Claire Jacques, nd Francis Berenbaum</p>
<p>16 Human Immunodeficiency Virus (HIV) 331<br /> Joseph P. Vacca</p>
<p>17 Allergy and Asthma 341<br /> Garry M. Walsh</p>
<p>18 Schizophrenia 357<br /> Ferenc Martenyi</p>
<p>19 Protein Misfolding and Disease 379<br /> Johanna C. Scheinost, Grant E. Boldt, and Paul Wentworth</p>
<p>20 Protein Trafficking Diseases 401<br /> Heidi M. Sampson and David Y. Thomas</p>
<p>21 Metabolic Diseases 419<br /> Cynthia M. Arbeeny</p>
<p>22 Mitochondrial Medicine 445<br /> Richard J. T. Rodenburg and Jan A. M. Smeitink</p>
<p>23 Lysosomal Disorders 461<br /> Doug A. Brooks and Maria Fuller</p>
<p>Index 483</p>
<p>PART I DRUG DISCOVERY AND DEVELOPMENT 1</p>
<p>1 The Role of Chemical Biology in Drug Discovery 3<br /> Andrew J. Pope</p>
<p>2 Computational Approaches to Drug Discovery and Development 23<br /> Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu, and Hualiang Jiang</p>
<p>3 Design and Selection of Small Molecule Inhibitors 41<br /> Jianwei Che, Yi Liu, and Nathanael S. Gray</p>
<p>4 Lead Optimization in Drug Discovery 65<br /> Craig W. Lindsley, David Weaver, Thomas M. Bridges, and J. Phillip Kennedy</p>
<p>5 Pharmacokinetics of Drug Candidates 83<br /> Ronald E. White</p>
<p>6 ADME Properties of Drugs 101<br /> Li Di and Edward H. Kerns</p>
<p>7 Drug Transport in Living Systems 115<br /> Yael Elbaz and Shimon Schuldiner</p>
<p>8 Blood–Brain Barrier: Considerations in Drug Development and Delivery 133<br /> David S. Miller and Brian T. Hawkins</p>
<p>9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery 147<br /> Zhong Zuo and Vincent H. L. Lee</p>
<p>10 Pharmaceuticals: Natural Products and Natural Product Models 165<br /> Sheo B. Singh</p>
<p>PART II CHEMICAL BIOLOGY TO UNDERSTAND AND TARGET DISEASE 203</p>
<p>11 The Role of Chemical Biology in Understanding and Treating<br /> Disease Are Small Molecule Correctors the Way of the Future? 205<br /> David Selwood</p>
<p>12 Anxiety Disorders 215<br /> Miklos Toth</p>
<p>13 Chronic Obstructive Pulmonary Disease (COPD) 245<br /> Peter J. Barnes</p>
<p>14 Depression 267<br /> Glen B. Baker and Nicholas D. Mitchell</p>
<p>15 Osteoarthritis 293<br /> Marjolaine Gosset, Jeremie Sellam, Claire Jacques, nd Francis Berenbaum</p>
<p>16 Human Immunodeficiency Virus (HIV) 331<br /> Joseph P. Vacca</p>
<p>17 Allergy and Asthma 341<br /> Garry M. Walsh</p>
<p>18 Schizophrenia 357<br /> Ferenc Martenyi</p>
<p>19 Protein Misfolding and Disease 379<br /> Johanna C. Scheinost, Grant E. Boldt, and Paul Wentworth</p>
<p>20 Protein Trafficking Diseases 401<br /> Heidi M. Sampson and David Y. Thomas</p>
<p>21 Metabolic Diseases 419<br /> Cynthia M. Arbeeny</p>
<p>22 Mitochondrial Medicine 445<br /> Richard J. T. Rodenburg and Jan A. M. Smeitink</p>
<p>23 Lysosomal Disorders 461<br /> Doug A. Brooks and Maria Fuller</p>
<p>Index 483</p>
