Preface; Part I. The Clinical Presentation of Neuropathic Pain: 1. History and physical examination Pam Squire and John Xavier Pereira; 2. Diagnostic testing in chronic neuropathic pain patients Vishal Gupta and Michael Serpell; 3. Epidemiological considerations in neuropathic pain Didier Bouhassira and Nadine Attal; Part II. The Condition of Neuropathic Pain: 4. An overview of animal models for neuropathic pain Patrick L. Stemkowski and Peter A. Smith; 5. Peripheral and central sensitization Cory Toth; 6. Pathophysiology of neuropathic pain: voltage-gated sodium and calcium channels Robyn Flynn and Christophe Altier; 7. Pathophysiology of neuropathic pain: inflammatory mediators Paul J. Austin and Gila Moalem-Taylor; 8. Pathophysiology of neuropathic pain: signaling pathways and their magnification – the role of neuronal toll-like receptors Michael R. Due, Yohance M. Allete and Fletcher A. White; Part III. The Specific Condition: Peripheral Neuropathic Pain: 9. Diabetic and other peripheral neuropathies Cory Toth; 10. Postherpetic neuralgia: the prevention of a scourge C. Peter N. Watson; 11. Painful conditions affecting the nerve roots and plexus Kristine M. Chapman and Amanda Sherwin; Part IV. The Specific Condition: Central Neuropathic Pain: 12. Neuropathic pain following spinal cord injury Jan H. Vranken; 13. Central pain symptoms in multiple sclerosis Scott Jarvis and Bradley J. Kerr; 14. Central post-stroke pain Maan Kattan and Dwight E. Moulin; Part V. The Specific Condition: Other Causes of Neuropathic Pain: 15. The complex regional pain syndromes and post-traumatic neuralgias Anne Louise Oaklander and Steven H. Horowitz; 16. The management of neuropathic pain in cancer patients Wojciech Leppert; 17. Fibromyalgia Mary-Ann Fitzcharles and Peter Ste-Marie; Part VI. The Management of Neuropathic Pain: 18. Antidepressants: TCA and SNRIs Maija Haanpää; 19. Gabapentinoids and other anticonvulsants Howard S. Smith, Charles E. Argoff, Manpreet Kaur and Harsha Nagaraja; 20. Opioids Andrea D. Furlan and Angela Mailis-Gagnon; 21. Cannabinoids Mark A. Ware; 22. Local anesthetics and other interventional approaches Ian Carroll; 23. Spinal cord stimulation and other neuromodulation Krishna Kumar and Syed Rizvi; 24. Drug synergy and therapeutic combinations Stephan A. Schug; 25. The person with pain perspective and participation – an essential component of successfully managing chronic neuropathic pain Lynn Kerene Cooper; Part VII. The Prognosis of Neuropathic Pain: 26. Measuring outcomes in chronic neuropathic pain Nadine Attal; 27. Impact of chronic pain upon anxiety, sleep, and mood dimensions Scott Jarvis and Cory Toth; 28. Impact upon related conditions and quality of life Bharati Vyawahare and John Hughes; 29. The future: new concepts and potential therapies Nicole M. Sumracki, Lauren Nicotra, Yuen Kwok, Liang Liu, Krista van Steeg, Linda R. Watkins and Mark R. Hutchinson; Index.