I. Background Issues in Hypertension.- 1 Studies Justifying the Use of Treatment to Prevent Cardiovascular Events.- 2 Effects of Aging on Blood Pressure.- 3 Effects of Race on Blood Pressure.- 4 Genetics in Hypertension.- 5 Sodium and Other Dietary Factors.- 6 Role of Stress in Development of Hypertension.- 7 Neuroendocrine Factors: Role of the Sympathetic Nervous and Renin Angiotensin Systems.- 8 Left Ventricular Hypertrophy and Diastolic Dysfunction.- 9 Role of the Endothelium in Hypertension.- II. Diagnosis and Special Tests.- 10 Systolic, Diastolic, Mean, or Pulse Pressure: Which Is the Best Predictor of Hypertensive Cardiovascular Risk?.- 11 Manual Blood Pressure Measurement—Still the Gold Standard: Why and How to Measure Blood Pressure the Old Fashioned Way.- 12 Initial Routine Tests for Diagnosis and Risk Stratification of the Patient with Hypertension: What Is Mandatory?.- 13 When to Suspect Secondary Hypertension.- 14 Evaluation of Renal Function and Proteinuria.- 15 Ambulatory Blood Pressure Monitoring.- 16 Arterial Compliance in Hypertension.- III. Principles of Treatment.- 17 Starting Hypertension Treatment: Setting Targets.- 18 Choosing the First Agent.- 19 Managing an Inadequate Response to the First Agent: Changing Doses or Drugs, Adding Drugs.- 20 Rationale of Low-Dose Combination Therapy in Cardiovascular Risk Management.- 21 How to Monitor Progress in Hypertensive Patients.- 22 Problems of Treatment Compliance and Polypharmacy.- 23 Should Treatment Differ in African-American and Caucasian Patients?.- 24 Measuring the Benefits of Antihypertensive Treatment.- IV. Major Hypertensive Drug Classes.- 25 Diuretics in Hypertension Therapy.- 26 ?-Adrenergic Blocker Treatment of Hypertension: Pharmacodynamics and Guide to Patient Selection.- 27 CalciumAntagonists.- 28 Angiotensin-Converting Enzyme Inhibitors.- 29 The Angiotensin II Receptor Blockers.- 30 Selective ?1 — Blockers.- 31 Centrally Acting Antihypertensive Drugs.- V. Solving Problems in Hypertension Management.- 32 The National Health and Nutrition Examination Survey III: How Are We Doing with Blood Pressure Control?.- 33 Lipid Abnormalities and Hypertension.- 34 Diabetes and Hypertension.- 35 Treatment of Hypertensive Patients with Chronic Renal Insufficiency.- 36 Treating Angina Pectoris in Hypertension.- 37 Hypertension and Its Treatment in Concomitant Conditions: Degenerative Joint Disease, Depression, Alzheimer’s Disease, and Parkinson’s Disease.- 38 Cognitive Disorders and Dementia in Hypertension: Implications for Treatment.- 39 Refractory Hypertension.- 40 Hypertensive Emergencies.- 41 Referring to Hypertension Experts: The Hypertension Consultant.