1. Global perspectives on mental-physical comorbidity Michael R. Von Korff; Part I. An Epidemiological Map of Mental-Physical Comorbidity: 2. The global burden of chronic physical disease Michael R. Von Korff; 3. The global burden of chronic pain Adley Tsang and Sing Lee; 4. World Mental Health Survey methods for studying mental-physical comorbidity Gemma Vilagut, Kathleen Saunders, and Jordi Alonso; 5. The pattern and nature of mental-physical comorbidity: specific or general Oye Gureje; 6. Age patterns in the prevalence of depressive and anxiety disorders by physical comorbidity status Kate M. Scott; Part II. Risk Factors for Mental-Physical Comorbidity: 7. The development of mental-physical comorbidity Kate M. Scott; 8. Childhood adversity, early-onset mental disorders and adult-onset asthma Kate M. Scott; 9. Childhood adversities, mental disorders and heart disease Huibert Burger; 10. Early childhood adversities and later hypertension Dan Stein, Kate M. Scott, and Michael R. Von Korff; 11. Early life psychosocial factors and adult-onset diabetes Carmen Lara; 12. Psychosocial stressors in childhood and adult-onset arthritis Michael R. Von Korff; 13. The role of childhood adversities in adult-onset spinal pain Koen Demyttenaere and Ronny Bruffaerts; 14. Childhood adversities and adult obesity Ronny Bruffaerts and Koen Demyttenaere; 15. Linking depression-anxiety disorders and headache in a developmental perspective: the role of childhood family adversities Adley Tsang and Sing Lee; 16. Women, depression and mental-physical comorbidity: chronic pain as a mediating factor Oye Gureje; Part III. Consequences of Mental-Physical Comorbidity: 17. Understanding consequences of mental-physical comorbidity Michael R. Von Korff; 18. Disability and treatment of specific mental and physical disorders Johan Ormel, Maria Petukhova, Michael R. Von Korff, and Ronald C. Kessler; 19. Mental-physical comorbidity and its relationship with disability Kate M. Scott; 20. Disability in 'pure' vs. 'comorbid' mental and physical conditions Paul K. Crane; 21. Labor force participation, unemployment and mental-physical comorbidity Michael R. Von Korff; 22. Perceived stigma and mental-physical comorbidity Jordi Alonso, Andrea Buron, and Gemma Vilagut; 23. How physical comorbidity affects treatment of major depression in developing and developed countries Oye Gureje; 24. Mental-physical comorbidity and predicted mortality Huibert Burger; Part IV. Implications: 25. Research implications Evelyn Bromet and Michael R. Von Korff; 26. Clinical implications Gregory E. Simon; 27. Policy implications Sergio Aguilar-Gaxiola; Appendices.