J Cossy
John Wiley & Sons
e druk, 2012
9780470616185
Modern Tools for the Synthesis of Complex Bioactive Molecules
Specificaties
Gebonden, 596 blz.
|
Engels
John Wiley & Sons |
e druk, 2012
ISBN13: 9780470616185
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
An overview of the new technologies that have revolutionized organic chemistry and allowed easy access to complex bioactives, this book brings modern synthetic techniques and bioactives together. The synthesis of structurally complex molecules has become a real challenge for the synthetic community. The development of innovative methodologies enabling control of the exact connectivity of the atoms within a molecule and setting correct three–dimensional arrangements, have gained a great interest. Combining representative experimental procedures for particular methods, the book is suited for advanced students, researchers, and pharmaceutical employees.
Specificaties
Inhoudsopgave
<p>FOREWORD vii</p>
<p>PREFACE ix</p>
<p>CONTRIBUTORS xi</p>
<p>CHAPTER 1 C H FUNCTIONALIZATION: A NEW STRATEGY FOR THE SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS 1<br /> Sophie Rousseaux, Benoý t Lie´gault, and Keith Fagnou</p>
<p>CHAPTER 2 THE NEGISHI CROSS–COUPLING IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOACTIVE MOLECULES 33<br /> Evelina Colacino, Jean Martinez, and Fre´de´ric Lamaty</p>
<p>CHAPTER 3 METAL–CATALYZED C HETEROATOM CROSS–COUPLING REACTIONS 77<br /> Renata Marcia de Figueiredo, Jean Marc Campagne, and Damien Prim</p>
<p>CHAPTER 4 GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS 111<br /> Fabien Gagosz</p>
<p>CHAPTER 5 METATHESIS–BASED SYNTHESIS OF COMPLEX BIOACTIVES 155<br /> Jean–Alexandre Richard, Sin Yee Ng, and David Y.–K. Chen</p>
<p>CHAPTER 6 ENANTIOSELECTIVE ORGANOCATALYSIS: A POWERFUL TOOL FOR THE SYNTHESIS OF BIOACTIVE MOLECULES 189<br /> Mitsuru Shoji and Yujiro Hayashi</p>
<p>CHAPTER 7 ASYMMETRIC PHASE–TRANSFER CATALYSIS 213<br /> Seiji Shirakawa, Shin A. Moteki, and Keiji Maruoka</p>
<p>CHAPTER 8 REARRANGEMENTS IN NATURAL PRODUCT SYNTHESIS 243<br /> Jose´ Marco–Contelles and Elena Soriano</p>
<p>CHAPTER 9 DOMINO REACTIONS IN THE ENANTIOSELECTIVE SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS 271<br /> Lutz F. Tietze, Scott G. Stewart, and Alexander Du¨fert</p>
<p>CHAPTER 10 FLUOROUS LINKER–FACILITATED SYNTHESIS OF BIOLOGICALLY INTERESTING MOLECULES 335<br /> Wei Zhang</p>
<p>CHAPTER 11 THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIR APPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL PRODUCTS AND PHARMACEUTICAL COMPOUNDS 359<br /> Rebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale, and Steven V. Ley</p>
<p>CHAPTER 12 SYNTHETIC APPROACHES TO BIOACTIVE CARBOHYDRATES 395<br /> Xavier Guinchard, Se´bastien Picard, and David Crich</p>
<p>CHAPTER 13 AMMONIUM YLIDES AS BUILDING BLOCKS FOR ALKALOID SYNTHESIS 433<br /> Scott Bur and Albert Padwa</p>
<p>CHAPTER 14 PRECURSOR–DIRECTED BIOSYNTHESIS OF POLYKETIDE AND NONRIBOSOMAL PEPTIDE NATURAL PRODUCTS 485<br /> Colin J. B. Harvey and Chaitan Khosla</p>
<p>CHAPTER 15 TARGET–ORIENTED AND DIVERSITY–ORIENTED ORGANIC SYNTHESIS 513<br /> Raphae¨l Rodriguez</p>
<p>CHAPTER 16 DNA AS A TOOL FOR MOLECULAR DISCOVERY 539<br /> Michael Smietana, Jean–Jacques Vasseur, Janine Cossy, and Stellios Arseniyadis</p>
<p>INDEX 557</p>
<p>PREFACE ix</p>
<p>CONTRIBUTORS xi</p>
<p>CHAPTER 1 C H FUNCTIONALIZATION: A NEW STRATEGY FOR THE SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS 1<br /> Sophie Rousseaux, Benoý t Lie´gault, and Keith Fagnou</p>
<p>CHAPTER 2 THE NEGISHI CROSS–COUPLING IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOACTIVE MOLECULES 33<br /> Evelina Colacino, Jean Martinez, and Fre´de´ric Lamaty</p>
<p>CHAPTER 3 METAL–CATALYZED C HETEROATOM CROSS–COUPLING REACTIONS 77<br /> Renata Marcia de Figueiredo, Jean Marc Campagne, and Damien Prim</p>
<p>CHAPTER 4 GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURAL PRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS 111<br /> Fabien Gagosz</p>
<p>CHAPTER 5 METATHESIS–BASED SYNTHESIS OF COMPLEX BIOACTIVES 155<br /> Jean–Alexandre Richard, Sin Yee Ng, and David Y.–K. Chen</p>
<p>CHAPTER 6 ENANTIOSELECTIVE ORGANOCATALYSIS: A POWERFUL TOOL FOR THE SYNTHESIS OF BIOACTIVE MOLECULES 189<br /> Mitsuru Shoji and Yujiro Hayashi</p>
<p>CHAPTER 7 ASYMMETRIC PHASE–TRANSFER CATALYSIS 213<br /> Seiji Shirakawa, Shin A. Moteki, and Keiji Maruoka</p>
<p>CHAPTER 8 REARRANGEMENTS IN NATURAL PRODUCT SYNTHESIS 243<br /> Jose´ Marco–Contelles and Elena Soriano</p>
<p>CHAPTER 9 DOMINO REACTIONS IN THE ENANTIOSELECTIVE SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS 271<br /> Lutz F. Tietze, Scott G. Stewart, and Alexander Du¨fert</p>
<p>CHAPTER 10 FLUOROUS LINKER–FACILITATED SYNTHESIS OF BIOLOGICALLY INTERESTING MOLECULES 335<br /> Wei Zhang</p>
<p>CHAPTER 11 THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIR APPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL PRODUCTS AND PHARMACEUTICAL COMPOUNDS 359<br /> Rebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale, and Steven V. Ley</p>
<p>CHAPTER 12 SYNTHETIC APPROACHES TO BIOACTIVE CARBOHYDRATES 395<br /> Xavier Guinchard, Se´bastien Picard, and David Crich</p>
<p>CHAPTER 13 AMMONIUM YLIDES AS BUILDING BLOCKS FOR ALKALOID SYNTHESIS 433<br /> Scott Bur and Albert Padwa</p>
<p>CHAPTER 14 PRECURSOR–DIRECTED BIOSYNTHESIS OF POLYKETIDE AND NONRIBOSOMAL PEPTIDE NATURAL PRODUCTS 485<br /> Colin J. B. Harvey and Chaitan Khosla</p>
<p>CHAPTER 15 TARGET–ORIENTED AND DIVERSITY–ORIENTED ORGANIC SYNTHESIS 513<br /> Raphae¨l Rodriguez</p>
<p>CHAPTER 16 DNA AS A TOOL FOR MOLECULAR DISCOVERY 539<br /> Michael Smietana, Jean–Jacques Vasseur, Janine Cossy, and Stellios Arseniyadis</p>
<p>INDEX 557</p>