Duarte Miguel F. Prazeres
John Wiley & Sons
e druk, 2011
9780470232927
Plasmid Biopharmaceuticals
Basics, Applications, and Manufacturing
Specificaties
Gebonden, 616 blz.
|
Engels
John Wiley & Sons |
e druk, 2011
ISBN13: 9780470232927
Rubricering
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
The book addresses the basics, applications, and manufacturing of plasmid biopharmaceuticals. The survey of the most relevant characteristics of plasmids provides the basics for designing plasmid products (applications) and processes (manufacturing). Key features that the authors include in the book are: i) consistency and clear line of direction, ii) an extensive use of cross–referencing between the individual chapters, iii) a rational integration of chapters, iv) appellative figures, tables and schemes, and v) an updated, but selected choice of references, with a focus on key papers.
Specificaties
Inhoudsopgave
Preface.
<p>Acknowledgment.</p>
<p>Abbreviations.</p>
<p>Part I Basics.</p>
<p>1 Historical Perspective.</p>
<p>2 Gene Transfer with Plasmid Biopharmaceuticals.</p>
<p>3 Product and Process Development.</p>
<p>4 Structure.</p>
<p>5 Analytical Characterization.</p>
<p>6 Delivery.</p>
<p>Part II Applications.</p>
<p>7 Ethical and Safety Issues.</p>
<p>8 Human and Veterinary Markets.</p>
<p>9 Human Case Studies: Pandemic Infl uenza and Critical Limb Ischemia.</p>
<p>10 Veterinary Case Studies: West Nile, Infectious Hematopoietic Necrosis, and Melanoma.</p>
<p>Part III Manufacturing.</p>
<p>11 Good Manufacturing Practice and Validation.</p>
<p>12 Product Specifi cations and Quality Control.</p>
<p>13 Cell Culture.</p>
<p>14 An Overview of Downstream Processing.</p>
<p>15 Primary Isolation.</p>
<p>16 Intermediate Recovery.</p>
<p>17 Final Purifi cation.</p>
<p>18 Process Synthesis.</p>
<p>Part IV Concluding Remarks and Outlook.</p>
<p>19 Concluding Remarks and Outlook.</p>
<p>Index.</p>
<p>Acknowledgment.</p>
<p>Abbreviations.</p>
<p>Part I Basics.</p>
<p>1 Historical Perspective.</p>
<p>2 Gene Transfer with Plasmid Biopharmaceuticals.</p>
<p>3 Product and Process Development.</p>
<p>4 Structure.</p>
<p>5 Analytical Characterization.</p>
<p>6 Delivery.</p>
<p>Part II Applications.</p>
<p>7 Ethical and Safety Issues.</p>
<p>8 Human and Veterinary Markets.</p>
<p>9 Human Case Studies: Pandemic Infl uenza and Critical Limb Ischemia.</p>
<p>10 Veterinary Case Studies: West Nile, Infectious Hematopoietic Necrosis, and Melanoma.</p>
<p>Part III Manufacturing.</p>
<p>11 Good Manufacturing Practice and Validation.</p>
<p>12 Product Specifi cations and Quality Control.</p>
<p>13 Cell Culture.</p>
<p>14 An Overview of Downstream Processing.</p>
<p>15 Primary Isolation.</p>
<p>16 Intermediate Recovery.</p>
<p>17 Final Purifi cation.</p>
<p>18 Process Synthesis.</p>
<p>Part IV Concluding Remarks and Outlook.</p>
<p>19 Concluding Remarks and Outlook.</p>
<p>Index.</p>