Down Syndrome: From Understanding the Neurobiology to Therapy

<ol> <li>Therapeutic approaches in the improvement of cognitive performance in Down syndrome: past, present and future</li> <p>Rafael de la Torre and Mara Dierssen</p> <p> <li>Genomic determinants in the phenotypic variability of Down syndrome</li> <p>Audrey Letourneau and Stylianos E. Antonarakis</p> <p> <li>Intellectual disabilities, neuronal post-transcriptional RNA-metabolism and RNA-binding proteins: three actors for a complex scenario</li> <p>Barbara Bardoni, Sabiha Abekhoukh, Samantha Zongaro and Mireille Melko</p> <p> <li>Aberrant epigenetic landscape in mental retardation</li> <p>Sanchez-Mut JV, Huertas D. and Esteller M.</p> <p> <li>Pathways to cognitive deficits in Down syndrome</li> <p>Xiaolu Sturgeon, Thanh Le, Md. Mahiuddin Ahmed and Katheleen J. Gardiner</p> <p> <li>Neurological Phenotypes for Down Syndrome across the Lifespan</li> <p>Ira T. Lott, MD</p> <p> <li>Human and mouse model cognitive phenotypes in Down syndrome: Implications for assessment</li> <p>Jamie O. Edgin, Gina M. Mason, Goffredina Spanò, Andrea Fernández and Lynn Nadel</p> <p> <li>Perturbation of dendritic protrusions in intellectual disability</li> <p>Josien Levenga and Rob Willemsen</p> <p> <li>The in vivo Down syndrome genomic library in mouse</li> <p>Yann Herault, Arnaud Duchon, Emilie Velot, Damien Maréchal and Véronique Brault</p> <p> <li>Discoveries in Down Syndrome: Moving Basic Science to Clinical Care</li> <p>A.M. Kleschevnikov, P.V. Belichenko, A. Salehi and C. Wu</p> <p> <li>A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome</li> <p>Duane G. Currier, Renita C. Polk and Roger H. Reeves</p> <p> <li>Gene therapy for Down syndrome<br><br>Cristina Fillat<SUP> </SUP>and Xavier Altafaj</li></ol>