Serotonin-Dopamine Interaction: Experimental Evidence and Therapeutic Relevance

1. SEROTONIN-DOPAMINE INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM<br>1. Serotonin-Dopamine Interaction: an overview.<br>2. Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies.<br>3. Serotonin-Dopamine Interaction: electrophysiological evidence.<br>4. Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders.<br><br>2. SEROTONIN-DOPAMINE INTERACTIONS IN SCHIZOPHRENIA<br>5. Distribution of 5-HT and DA receptors in primate prefrontal cortex: implications for pathophysiology and treatment.<br>6. Alterations of dopamine and serotonin transmission in schizophrenia.<br>7. Serotonin and dopamine interactions in psychosis prevention.<br>8. Role of serotonin and dopamine receptor binding in antipsychotic efficacy.<br>9. In vivo actions of atypical antipsychotic drug on serotonergic and dopaminergic systems.<br>10. Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis.<br>11. Serotonin-dopamine interactions: implications for the design of novel therapeutic agents for psychiatric disorders.<br><br>3. SEROTONIN-DOPAMINE INTERACTIONS IN DEPRESSION<br>12. The dorsal raphe nucleus and serotonin —implications for neuroplasticity linked to major depression and Alzheimer’s disease.<br>13. Dynamics of the dopaminergic system as a key component to the understanding of depression.<br>14. Physiological and therapeutic relevance of constitutive activity of 5-HT2A and 5-HT2C receptors for the treatment of depression.<br>15. The role of dopamine and serotonin in suicidal behaviour and aggression.<br><br>4. SEROTONIN-DOPAMINE INTERACTIONS IN DRUG ADDICTION<br>16. Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse. <br>17. Pharmacological inhibition of dopamine- and serotonin activity blocks spontaneous and cocaine-activated behaviour.<br>18. Serotonin receptors as potential targets for modulation of nicotine use and dependence.<br>19. Dopamine/Serotonin releasers as medications for stimulant addictions.<br>20. PTEN-5-HT2C coupling: A new target for treating drug addiction.<br><br>5. SEROTONIN-DOPAMINE INTERACTIONS IN MOTOR DISORDERS<br>21. Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson’s disease and other motor disorders. <br>22. Serotonin-Dopamine interaction in the induction and maintenance of LDOPA-induced dyskinesias.<br>23. Parkinson’s disease – opportunities for novel therapeutics to reduce the problems of levodopa therapy.<br>24. Neurobiological basis of serotonin-dopamine antagonists in the treatment of Gilles de la Tourette syndrome.<br><br>6. SEROTONIN-DOPAMINE INTERACTIONS IN ATTENTIONAL PROCESSES, LEARNING AND MEMORY<br>25. Serotonergic and dopaminergic modulation of attentional processes.<br>26. Dopamine-serotonin interactions in attention-deficit/hyperactivity disorder (ADHD).<br>27. Serotonin/dopamine interaction in learning.<br>28. Serotonin-dopamine interaction in memory formation.<br>29. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking.